Inference of switched biochemical reaction networks using sparse bayesian learning

in The proceedings of the 7th European Conference on Machine Learning and Principles and Practice of Knowledge Discovery in Databases (ECML/PKDD) (2014)

This paper proposes an algorithm to identify biochemical reaction networks with time-varying kinetics. We formulate the problem as a nonconvex optimisation problem casted in a sparse Bayesian learning ... [more ▼]

This paper proposes an algorithm to identify biochemical reaction networks with time-varying kinetics. We formulate the problem as a nonconvex optimisation problem casted in a sparse Bayesian learning framework. The nonconvex problem can be efficiently solved using Convex-Concave programming. We test the effectiveness of the method on a simulated example of DNA circuit realising a switched chaotic Lorenz oscillator. [less ▲]