References of "Nadeau, J"
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See detailPax genes and skeletal development.
Balling, Rudi UL; Helwig, U.; Nadeau, J. et al

in Annals of the New York Academy of Sciences (1996), 785

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Peer Reviewed
See detailAnalysis of the Pax-3 gene in the mouse mutant splotch.
Goulding, M.; Sterrer, S.; Fleming, J. et al

in Genomics (1993), 17(2), 355-63

In a linkage analysis of Pax-3 and splotch no recombinations were found in 117 backcross mice. Molecular analysis of Pax-3 in three alleles of splotch shows a number of significant alterations to the Pax ... [more ▼]

In a linkage analysis of Pax-3 and splotch no recombinations were found in 117 backcross mice. Molecular analysis of Pax-3 in three alleles of splotch shows a number of significant alterations to the Pax-3 gene. In Sp/Sp embryos, cDNA PCR analysis reveals a shortened transcript in which exon 4 of Pax-3 is deleted due to mutation of the splice acceptor site of intron 3. In the Sp4H allele, the Pax-3 gene is deleted and in Spd embryos, Pax-3 expression is significantly lower than that in normal littermate embryos. The linkage analysis, shortened Pax-3 transcript in Sp, and deletion of Pax-3 in Sp4H described here, together with the previous report of an intragenic deletion in Pax-3 in Sp2H mice and the deletion of Pax-3 in Spr mice, provide strong evidence for the allelic identity of Pax-3 and Sp. [less ▲]

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