References of "Dhein, J."
     in
Bookmark and Share    
Peer Reviewed
See detailThe role of APO-1-mediated apoptosis in the immune system
Krammer, P. H.; Dhein, J.; Walczak, H. et al

in Immunological Reviews (1995), 142

Detailed reference viewed: 118 (0 UL)
Peer Reviewed
See detailAPO-I-mediated apoptosis in normal and malignant lymphocytes
Dhein, J.; Behrmann, Iris UL; Daniel, P. T. et al

in Biochemical Society Transactions (1995), 22(3), 598-600

Detailed reference viewed: 94 (0 UL)
Peer Reviewed
See detailRegulation of apoptosis in the immune system
Krammer, P. H.; Behrmann, Iris UL; Daniel, P. T. et al

in Current Opinion in Immunology (1994), 6(2), 279-89

Apoptosis in T and B lymphocytes is involved in all fundamental processes in the immune system. It is a mechanism to regulate the course of an immune response and to establish immunological memory as well ... [more ▼]

Apoptosis in T and B lymphocytes is involved in all fundamental processes in the immune system. It is a mechanism to regulate the course of an immune response and to establish immunological memory as well as central and peripheral tolerance. Apoptosis in lymphocytes is regulated by gene products that induce or block this process. Elucidating the molecular basis for sensitivity and resistance towards induction of apoptosis is the key to the understanding of the development of the immune system, basic immune reactions and the pathogenesis of autoimmune diseases, AIDS and cancer. [less ▲]

Detailed reference viewed: 96 (0 UL)
Peer Reviewed
See detailPurification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen
Oehm, A.; Behrmann, Iris UL; Falk, W. et al

in Journal of Biological Chemistry (1992), 267(15), 10709-15

The APO-1 antigen as defined by the mouse monoclonal antibody anti-APO-1 was previously found to be expressed on the cell surface of activated human T and B lymphocytes and a variety of malignant human ... [more ▼]

The APO-1 antigen as defined by the mouse monoclonal antibody anti-APO-1 was previously found to be expressed on the cell surface of activated human T and B lymphocytes and a variety of malignant human lymphoid cell lines. Cross-linking of the APO-1 antigen by anti-APO-1 induced programmed cell death, apoptosis, of APO-1 positive cells. To characterize the APO-1 cell surface molecule and to better understand its role in induction of apoptosis, the APO-1 protein was purified to homogeneity from membranes of SKW6.4 B lymphoblastoid cells by solubilization with sodium deoxycholate, affinity chromatography with anti-APO-1 antibody, and reversed phase high performance liquid chromatography. Each purification step was followed by an APO-1-specific solid phase enzyme-linked immunosorbent assay using the monoclonal antibody anti-APO-1. In sodium dodecyl sulfate-polyacrylamide gel electrophoresis, the APO-1 antigen was found to be a membrane glycoprotein of 48-kDa. Endoproteinase-cleaved peptides of the APO-1 protein were subjected to amino acid sequencing, and corresponding oligonucleotides were used to identify a full-length APO-1 cDNA clone from an SKW6.4 cDNA library. The deduced amino acid sequence of APO-1 showed sequence identity with the Fas antigen, a cysteine-rich transmembrane protein of 335 amino acids with significant similarity to the members of the tumor necrosis factor/nerve growth factor receptor superfamily. The APO-1 antigen was expressed upon transfection of APO-1 cDNA into BL60-P7 Burkitt's lymphoma cells and conferred sensitivity towards anti-APO-1-induced apoptosis to the transfectants. [less ▲]

Detailed reference viewed: 64 (0 UL)