Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailAn efficient approach towards the source-target control of Boolean networks
Paul, Soumya UL; Su, Cui UL; Pang, Jun UL et al

in IEEE/ACM Transactions on Computational Biology and Bioinformatics (in press)

We study the problem of computing a minimal subset of nodes of a given asynchronous Boolean network that need to be perturbed in a single-step to drive its dynamics from an initial state to a target ... [more ▼]

We study the problem of computing a minimal subset of nodes of a given asynchronous Boolean network that need to be perturbed in a single-step to drive its dynamics from an initial state to a target steady state (or attractor), which we call the source-target control of Boolean networks. Due to the phenomenon of state-space explosion, a simple global approach that performs computations on the entire network, may not scale well for large networks. We believe that efficient algorithms for such networks must exploit the structure of the networks together with their dynamics. Taking this view, we derive a decomposition-based solution to the minimal source-target control problem which can be significantly faster than the existing approaches on large networks. We then show that the solution can be further optimised if we take into account appropriate information about the source state. We apply our solutions to both real-life biological networks and randomly generated networks, demonstrating the efficiency and efficacy of our approach. [less ▲]

Detailed reference viewed: 26 (0 UL)
Full Text
Peer Reviewed
See detailCase Study: Analysis and Mitigation of a Novel Sandbox-Evasion Technique
Genç, Ziya Alper UL; Lenzini, Gabriele UL; Sgandurra, Daniele

in 3rd Central European Cybersecurity Conference (in press)

Malware is one of the most popular cyber-attack methods in the digital world. According to the independent test company AV-TEST, 350,000 new malware samples are created every day. To analyze all samples ... [more ▼]

Malware is one of the most popular cyber-attack methods in the digital world. According to the independent test company AV-TEST, 350,000 new malware samples are created every day. To analyze all samples by hand to discover whether they are malware does not scale, so antivirus companies automate the process e.g., using sand- boxes where samples can be run, observed, and classified. Malware authors are aware of this fact, and try to evade detection. In this paper we describe one of such evasion technique: unprecedented, we discovered it while analyzing a ransomware sample. Analyzed in a Cuckoo Sandbox, the sample was able to avoid triggering malware indicators, thus scoring significantly below the minimum severity level. Here, we discuss what strategy the sample follows to evade the analysis, proposing practical defense methods to nullify, in our turn, the sample’s furtive strategy. [less ▲]

Detailed reference viewed: 28 (2 UL)
Full Text
Peer Reviewed
See detailOvercome of bed-joint imperfections and improvement of actual contact in dry-stacked masonry
Chewe Ngapeya, Gelen Gael UL; Waldmann, Danièle UL

in Construction and Building Materials (in press)

Several researchers studied dry-stacked masonry walls (DSM) and inferred that the actual contact surface between the different block rows and the compressive strength in such walls are reduced by bed ... [more ▼]

Several researchers studied dry-stacked masonry walls (DSM) and inferred that the actual contact surface between the different block rows and the compressive strength in such walls are reduced by bed-joint imperfections as well as by height differences between different masonry blocks leading both to high stress concentration. This paper concentrates on the first type on imperfections. Through experimental tests, it analyses the influence of bed-joint roughness on the load bearing capacity and investigates a strategy to improve the load-bearing capacity of DSM by placing an additional horizontal layer on the top face of raw masonry blocks. First, different contact layers using conventional and auxetic materials were applied. Then 20 dry-stacked masonry prisms built with raw and improved masonry blocks were tested under axial compressive load until failure. Prescale Fujifilm strips were used to measure the actual contact in the bed-joints. Experimental tests show that the use of a contact layer with well-defined material properties enables firstly to increase the actual contact area in the bed-joints from 23% to 98% of the nominal contact area and secondly to increase the load-bearing capacity by 14 to 97%. In addition, the contact layer with an auxetic material shows a significant capacity in altering the lateral expansion in the block units. The outcomes show that although the bed joint roughness influences the stress distribution in a dry-stacked masonry block, a contact layer with well-defined material properties enables to overcome the roughness induced by the bed-joint imperfections. [less ▲]

Detailed reference viewed: 49 (0 UL)
See detailMit Lingscape auf Pad in die Schule. Zum Einsatz mobiler Forschungs-Apps im Schulunterricht
Purschke, Christoph UL

in Marten, Heiko; Ziegler, Evelyn (Eds.) Linguistic Landscapes im deutschsprachigen Kontext: Forschungsperspektiven, Methoden und Anwendungsmöglichkeiten im Unterricht und Sprachmarketing (in press)

Detailed reference viewed: 23 (0 UL)
Full Text
Peer Reviewed
See detailInternationale Disability Studies
Biermann, Julia; Powell, Justin J W UL

in Waldschmidt, Anne (Ed.) Handbuch Disability Studies (in press)

Der Beitrag zeichnet internationale Entwicklungen in den Disability Studies nach. Aufgrund der Bedeutung für die Entstehung und weltweite Verbreitung des multidisziplinären Forschungsfelds liegt der Fokus ... [more ▼]

Der Beitrag zeichnet internationale Entwicklungen in den Disability Studies nach. Aufgrund der Bedeutung für die Entstehung und weltweite Verbreitung des multidisziplinären Forschungsfelds liegt der Fokus auf den englischsprachigen Diskursen. Skizziert werden drei historische Phasen: die Etablierung der Disability Studies in den 1970er und 1980er Jahren, die Ausdifferenzierung in den 1990er und 2000er Jahren sowie die Pluralisierung seit den 2010er Jahren. [less ▲]

Detailed reference viewed: 33 (3 UL)
See detailDie Emanzipation des hybriden Selbst: Identität, Kultur und Literatur in Luxemburg
Baumann, Isabell UL

Book published by transcipt (in press)

Detailed reference viewed: 19 (0 UL)
Full Text
Peer Reviewed
See detailIntegrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson’s Disease
Hertel, Johannes; Harms, Amy C.; Heinken, Almut et al

in Cell Reports (in press)

Parkinson’s disease (PD) exhibits systemic effects on human metabolism with emerging roles for the gut microbiome. Here, we integrated longitudinal metabolome data from 30 drug-naïve, de-novo PD patients ... [more ▼]

Parkinson’s disease (PD) exhibits systemic effects on human metabolism with emerging roles for the gut microbiome. Here, we integrated longitudinal metabolome data from 30 drug-naïve, de-novo PD patients and 30 matched controls with constraint-based modeling of gut microbial communities derived from an independent, drug-naïve PD cohort, and prospective data from a general population. Our key results are i) longitudinal trajectory of metabolites associated with the interconversion of methionine and cysteine via cystathionine differed between PD patients and controls, ii) dopaminergic medication showed strong lipidomic signatures, iii) taurine-conjugated bile acids correlated with the severity of motor symptoms, while low levels of sulfated taurolithocholate were associated with incident PD in the general population, and iv) computational modeling predicted changes in sulfur metabolism, driven by A. muciniphila and B. wadsworthia, consistent with the changed metabolome. In conclusion, the multi-omics integration revealed PD-specific patterns in microbial-host sulfur co-metabolism that may contribute to PD severity. [less ▲]

Detailed reference viewed: 22 (4 UL)
Full Text
Peer Reviewed
See detailContact between shear-deformable beams with elliptical cross-sections
Magliulo, Marco UL; Zilian, Andreas UL; Beex, Lars UL

in Acta Mechanica (in press)

Slender constituents are present in many structures and materials. In associated mechanical models, each slender constituent is often described with a beam. Contact between beams is essential to ... [more ▼]

Slender constituents are present in many structures and materials. In associated mechanical models, each slender constituent is often described with a beam. Contact between beams is essential to incorporate in mechanical models, but associated contact frameworks are only demonstrated to work for beams with circular cross-sections. Only two studies have shown the ability to treat contact between beams with elliptical cross-sections, but those frameworks are limited to point-wise contact, which narrows their applicability. This contribution presents initial results of a framework for shear-deformable beams with elliptical cross-sections if contact occurs along a line or at an area (instead of at a point). This is achieved by integrating a penalty potential over one of the beams’ surfaces. Simo-Reissner Geometrically Exact Beam (GEB) elements are employed to discretise each beam. As the surface of an assembly of such beam elements is discontinuous, a smoothed surface is introduced to formulate the contact kinematics. This enables the treatment of contact for large sliding displacements and substantial deformations. [less ▲]

Detailed reference viewed: 36 (4 UL)
Full Text
Peer Reviewed
See detailLogic, evidence and consensus: Towards a more constructive debate on gaming disorder.
King, Daniel L.; Delfabbro, Paul H.; Potenza, Marc N. et al

in The Australian and New Zealand journal of psychiatry (in press)

Detailed reference viewed: 55 (1 UL)
Full Text
See detailUpdate Internationales und Europäisches Steuerrecht
Sinnig, Julia UL

in Taeger, Jürgen (Ed.) Tagungsband Herbstakademie 2019 (in press)

Im Juni 2019 stellte die Organisation für wirtschaftliche Zusammenarbeit und Entwicklung (OECD) das Arbeitsprogramm zur weiteren Ausarbeitung einer Anpassung des internationalen Ertragsteuerrechts an die ... [more ▼]

Im Juni 2019 stellte die Organisation für wirtschaftliche Zusammenarbeit und Entwicklung (OECD) das Arbeitsprogramm zur weiteren Ausarbeitung einer Anpassung des internationalen Ertragsteuerrechts an die neue wirtschaftliche Realität der digitalisierten Welt vor. Auf Ebene der Europäischen Union (EU) gilt die Verabschiedung der im März 2018 von der Europäischen Kommission vorgestellten Richtlinien-Vorschläge (RL-Vorschläge) zu einer Digitalsteuer und einer sog. signifikanten digitalen Präsenz, nach intensiver Diskussion im Rat, als unwahrscheinlich. Der Gerichtshof der Europäischen Union beschäftigt sich derzeit mit der unionsrechtlichen Vereinbarkeit nationaler Sonderabgaben, die umsatzbasiert erhoben werden. Dieser Beitrag bietet einen Überblick über wesentliche Entwicklungen im internationalen und europäischen Steuerrecht bzgl. der Besteuerung digitalisierter Unternehmen. Der Beitrag knüpft an den Vortrag von Prof. Dr. Jens M. Schmittmann und der Verfasserin anlässlich der Herbstakademie 2018 in Bochum, sowie dem Vortrag der Verfasserin anlässlich der Herbstakademie 2017 in Heidelberg an. [less ▲]

Detailed reference viewed: 61 (2 UL)
Full Text
Peer Reviewed
See detailFamiliale Generationsbeziehungen (international)
Albert, Isabelle UL; Schwarz, Beate; Mayer, Boris et al

in Ecarius, Jutta; Schierbaum, Anja (Eds.) Handbuch Familie: Bildung, Erziehung und sozialpädagogische Arbeitsfelder (in press)

Der vorliegende Beitrag beschäftigt sich mit intergenerationalen Familienbeziehungen im Kulturvergleich. Nach einer Einführung in grundlegende theoretische Modelle und Forschungstraditionen werden im ... [more ▼]

Der vorliegende Beitrag beschäftigt sich mit intergenerationalen Familienbeziehungen im Kulturvergleich. Nach einer Einführung in grundlegende theoretische Modelle und Forschungstraditionen werden im zweiten Teil Forschungsprojekte und -ergebnisse zur Ausgestaltung von Generationsbeziehungen in verschiedenen kulturellen Kontexten und im Zusammenhang mit Migration aufgezeigt sowie die Bedeutung von gesellschaftlichen Rahmenbedingungen für die Ausgestaltung von familiären Generationsbeziehungen dargelegt. [less ▲]

Detailed reference viewed: 22 (0 UL)
Full Text
Peer Reviewed
See detail“That’s a value I would transmit in some way, but how concretely, I don’t know” – Intergenerational value transfer revisited in light of memory
Albert, Isabelle UL; Barros, Stephanie; Boulanger, Dany

in Wagoner, Brady; Bresco, I.; Zadeh, S. (Eds.) Memory in the Wild (in press)

Intergenerational value transmission occurs widely and to a large extent within the family as primary socialization agent. In families, children are confronted with specific practices, paradigms, rules ... [more ▼]

Intergenerational value transmission occurs widely and to a large extent within the family as primary socialization agent. In families, children are confronted with specific practices, paradigms, rules and routines which are part of their family culture (Albert & Barros Coimbra, 2017) and as such family is a mediator between societal/cultural and individual values. The ability to transmit values is essential for collective knowledge and memory, the continuity of value orientations being a main feature of intergenerational relations that enables members of different generations to communicate with each other (Barni, Rosnati, & Ranieri, 2013; Halbwachs, 1941/1992; Schönpflug, 2001). Intergenerational transmission of values becomes particularly complex in the context of migration or in times of rapid social change. On the one hand, family identity and traditions might provide a secure base in light of a changing context, and parents might find it important to transmit traditional values to the next generation in order to keep memories alive. At the same time, they might feel that their children should adapt to the changed cultural context, resulting in a (not always clear) dilemma about what they want for their children. How can migrant parents reconcile or move between the different collective frameworks of their culture of origin and the receiving culture (Middleton & Brown, 2005)? In the following, we will first give a brief overview over research in the area of intergenerational value transmission, and we will second illustrate and further inform our theoretical assumptions by identifying related themes and phenomena in our qualitative dyadic interviews. Then, we will delve into memory as a horizon that is emerging out of the analysis as a transversal theme. From this point of view, we continue the analysis and progressively integrate the notions pertaining to the role of memory in the intergenerational transmission of values. Aspects of cultural background are apparent in the excerpts that we will quote supporting the themes we will refer to. We will more explicitly return to this in our conclusions. [less ▲]

Detailed reference viewed: 23 (0 UL)
Peer Reviewed
See detailZwischen Konformität und Handlungsmacht: Ein Blick auf die Verarbeitungspraxis von Qualitätsvorgaben in der Offenen Kinder- und Jugendarbeit
Biewers, Sandra UL

in Deinet, Ulrich; Sturzenhecker, Benedikt (Eds.) Handbuch Offene Kinder- und Jugendarbeit (in press)

Detailed reference viewed: 24 (1 UL)
See detailQualitätskonstruktionen - Zur Verarbeitung divergierender Qualitätsanforderungen in der Jugendarbeit
Biewers, Sandra UL

Book published by Beltz Juventa (in press)

Detailed reference viewed: 44 (0 UL)
See detailBrentanos Klingding. Eine Kulturpolitik der Buchstäblichkeit in der Romantik
Dembeck, Till UL

in Geisenhanslüke, Achim (Ed.) Buchstäblichkeit (in press)

Detailed reference viewed: 25 (0 UL)
Full Text
Peer Reviewed
See detailFeasibility of Stellar as a Blockchain-based Micropayment System
Khan, Nida UL; Ahmad, Tabrez; State, Radu UL

in Springer SmartBlock 2019 - 2nd International Conference on Smart Blockchain (in press)

The advent of Bitcoin was heralded as an innovation in the global monetary system, that could bring down transaction fees by circumventing the need for third parties and conduct transactions in real time ... [more ▼]

The advent of Bitcoin was heralded as an innovation in the global monetary system, that could bring down transaction fees by circumventing the need for third parties and conduct transactions in real time. The divisibility of a blockchain cryptocurrency to even fractions of a cent, caused microtransactions to become feasible to formerly non-existent denominations. These microtransactions have spurred the development of novel ways of monetizing online resources and hold the potential to aid in alleviation of poverty. The paper conducts a feasibility study on Stellar as a blockchain-based micropayment system. It highlights the computational and other issues that impedes its progress and utilizes a characterization model for micropayment systems to evaluate the efficacy of the Stellar platform. The paper conducts a comparison with the micropayment solutions from Bitcoin, Ethereum and PayPal. The paper analyzes a subset of transactions from the Stellar blockchain to aid in drawing a conclusion on the undertaken study and elaborates on the mitigation tools to enable fraud prevention in online monetary transactions. [less ▲]

Detailed reference viewed: 63 (12 UL)
See detailClemens Brentano’s “Sound-Thing” (Klingding). Homophonic Translation in German Romanticism
Dembeck, Till UL

in Weissmann, Dirk; Broqua, Vincent (Eds.) Sound / Writing: traduire-écrire entre le son et le sens / Homophonic translation – traducson – Oberflächenübersetzung (in press)

Detailed reference viewed: 25 (0 UL)
Full Text
Peer Reviewed
See detailInnovation Search Strategy and Predictable Returns
Fitzgerald, Tristan; Balsmeier, Benjamin UL; Fleming, Lee et al

in Management Science (in press)

Detailed reference viewed: 76 (0 UL)
Full Text
Peer Reviewed
See detailA Look into Privacy-Preserving Blockchains
Khan, Nida UL; Nassar, Mohamed

in IEEE BCA @AICCSA 2019 - Workshop on Blockchain and it's Applications (in press)

Blockchain is a revolutionary technology promising a new generation of decentralized, transparent and tamper-proof database systems. However, one of the main challenges of the emerging blockchain systems ... [more ▼]

Blockchain is a revolutionary technology promising a new generation of decentralized, transparent and tamper-proof database systems. However, one of the main challenges of the emerging blockchain systems remains to address data privacy. While in Bitcoin and similar e-cash systems, privacy was limited to anonymity and addressed by using cryptographic pseudonyms for identification and authentication of parties, the question of privacy has more breadth in systems maintaining actual data such as medical records or energy meters. In this paper, we look into recently proposed privacy-preserving blockchains, analyze their strengths and weaknesses, and highlight research questions requiring future investigation. We conclude that privacy-preserving blockchains are still in their infancy and more research is definitely needed in this area. [less ▲]

Detailed reference viewed: 51 (6 UL)
Full Text
Peer Reviewed
See detailA Bayesian framework to identify random parameter fields based on the copula theorem and Gaussian fields: Application to polycrystalline materials
Rappel, Hussein UL; Wu, Ling; Noels, Ludovic et al

in Journal of Applied Mechanics (in press)

For many models of solids, we frequently assume that the material parameters do not vary in space, nor that they vary from one product realization to another. If the length scale of the application ... [more ▼]

For many models of solids, we frequently assume that the material parameters do not vary in space, nor that they vary from one product realization to another. If the length scale of the application approaches the length scale of the micro-structure however, spatially fluctuating parameter fi elds (which vary from one realization of the fi eld to another) can be incorporated to make the model capture the stochasticity of the underlying micro-structure. Randomly fluctuating parameter fields are often described as Gaussian fields. Gaussian fi elds however assume that the probability density function of a material parameter at a given location is a univariate Gaussian distribution. This entails for instance that negative parameter values can be realized, whereas most material parameters have physical bounds (e.g. the Young's modulus cannot be negative). In this contribution, randomly fluctuating parameter fi elds are therefore described using the copula theorem and Gaussian fi elds, which allow di fferent types of univariate marginal distributions to be incorporated, but with the same correlation structure as Gaussian fields. It is convenient to keep the Gaussian correlation structure, as it allows us to draw samples from Gaussian fi elds and transform them into the new random fields. The bene fit of this approach is that any type of univariate marginal distribution can be incorporated. If the selected univariate marginal distribution has bounds, unphysical material parameter values will never be realized. We then use Bayesian inference to identify the distribution parameters (which govern the random fi eld). Bayesian inference regards the parameters that are to be identi fied as random variables and requires a user-defi ned prior distribution of the parameters to which the observations are inferred. For the homogenized Young's modulus of a columnar polycrystalline material of interest in this study, the results show that with a relatively wide prior (i.e. a prior distribution without strong assumptions), a single specimen is su ciffient to accurately recover the distribution parameter values. [less ▲]

Detailed reference viewed: 41 (3 UL)