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See detailThe Levodopa Response Trial and the Parkinson Disease Digital Biomarker Challenge: Monitoring symptoms of Parkinson’s disease in the lab and home using wearable sensors
Daneault, J.; Vergara-Diaz, G.; Costante, G. et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2018, October 03), 33(S2), 525

Objective: To leverage a community of researchers and shared wearable data to develop algorithms to estimate the severity of PD specific symptoms. Background: People with Parkinson’s disease (PwPD) often ... [more ▼]

Objective: To leverage a community of researchers and shared wearable data to develop algorithms to estimate the severity of PD specific symptoms. Background: People with Parkinson’s disease (PwPD) often experience fluctuations in motor symptom severity. Wearable sensors have the potential to help clinicians monitor symptoms over time, outside the clinic. However, to gather accurate and clinically-relevant measures, there is a need to develop robust algorithms based on clinically- labelled data. Methods: The Levodopa Response Trial captured three-axis acceleration from two wrist-worn sensors and a smartphone located at the waist from 29 PwPD continuously over 4 days. On day 1, in an in-clinic visit, participants performed clinical assessments and motor tasks on their regular medication regimen. During these visits, a clinician also provided symptom severity scores for tremor, bradykinesia, and dyskinesia. On days 2 & 3, sensor data was collected while participants were at home. On day 4, participants returned to the clinic for the same assessments as day 1, but arrived without having taken their medication for at least 10 hours. Leveraging this dataset, Sage Bionetworks, the Michael J Fox Foundation and the Robert Wood Johnson Foundation launched the PD Digital Biomarker DREAM Challenge which made a subset of the data available to researchers to develop robust and accurate algorithms for the estimation of specific symptoms’ severity. Results: Teams participating in the challenge used several technical approaches, from signal processing to deep learning. 35 submissions were received for the estimation of action tremor severity. Teams achieved an area under the precision-recall curve (AUPR) of 0.444 to 0.75. As for dyskinesia during movement, 37 submissions were received and the teams achieved an AUPR of 0.175 to 0.477. Finally, 39 submissions were received for the estimation of bradykinesia and the teams achieved an AUPR of 0.413 to 0.95. Null expectations for the testing datasets were 0.432, 0.195, and 0.266, respectively. Conclusions: Making datasets available to the community leverages the creativity of different groups to develop robust and accurate algorithms for the estimation of PD symptom severity. This will lead to better quality and interpretability of data collected in unsupervised settings within the community. [less ▲]

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See detailSub-second dynamic phototuning of alignment in azodendrimer-doped nematic liquid crystal shells
Noh, Junghyun UL; Jampani, Venkata UL; Haba, Osamu et al

in Journal of Molecular Liquids (2018), 267

The alignment of nematic liquid crystal 5CB in micron-thick shells, suspended in and containing aqueous liquid phases, can be rapidly switched between radial (homeotropic) and tangential (planar) director ... [more ▼]

The alignment of nematic liquid crystal 5CB in micron-thick shells, suspended in and containing aqueous liquid phases, can be rapidly switched between radial (homeotropic) and tangential (planar) director field by doping them with a photoresponsive dendrimer with multiple azobenzene moieties in the branches. The dendrimer spontaneously segregates to the inner as well as outer shell interfaces, folding into an amphiphilic conformation irrespective of the sign of interface curvature. The branches are directed into the liquid crystal, inducing a homeotropic ground state. Upon UV irradiation, the trans-cis isomerization of azobenzene triggers immediate switching to planar alignment. The very fast realignment and the simultaneous response throughout the shell leads to an initially random planar director field, with many topological defects of both positive and negative signs becoming visible within a second of irradiation. All but two +1 defects quickly annihilate, and the remaining defect pair moves up towards the thinnest part of the shell to form the planar steady state. By illuminating with visible light the homeotropic alignment is quickly recovered. By exchanging the solvent used for assisting the dendrimer dissolution, also dynamic phase separation phenomena can be studied in the shells, revealing that the dendrimer solubility in 5CB is greater in the UV-induced cis state than in the trans ground state. [less ▲]

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See detailNeuer Wein in alte Schläuche? Männlichkeit im Wandel
Kmec, Sonja UL

in Goetzinger, Germaine; Kmec, Sonja; Wagener, Renée (Eds.) et al Mit den Haien streiten. Frauen und Gender in Luxemburg seit 1940 / Femmes et genre au Luxembourg depuis 1940 (2018)

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See detailMoonlightBox: Mining Android API Histories for Uncovering Release-time Inconsistencies
Li, Li; Bissyande, Tegawendé François D Assise UL; Klein, Jacques UL

in 29th IEEE International Symposium on Software Reliability Engineering (ISSRE) (2018, October)

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See detailGood to be stressed? Improved response inhibition and error processing after acute stress in young and older men
Dierolf, Angelika UL; Schoofs, Daniela; Hessas, Eve-Mariek et al

in Neuropsychologia (2018), 119

own on whether and how age modulates stress effects on executive functions and their neural correlates. The current study investigated the effect of acute stress on response inhibition and error ... [more ▼]

own on whether and how age modulates stress effects on executive functions and their neural correlates. The current study investigated the effect of acute stress on response inhibition and error processing and their underlying cortical processes in younger and older healthy men, using EEG. Forty-nine participants (30 young) were stressed with the Trier Social Stress Test (16 young, 9 older) or underwent a friendly control procedure (14 young, 10 older) and subsequently performed a Go/No-Go task with two levels of task difficulty while performance (reaction time, error rate), stimulus-locked (N2, P3) and response-locked (Ne, Pe) ERPs were measured. Previous results on age-related cognitive deficits were replicated, with slower responses and reduced and delayed N2 and P3 components, as well as reduced Ne and Pe components in older participants. Independent of age, acute stress improved response inhibition, reflected in higher accuracy for compatible trials and enhanced inhibition-related components (N2, P3 and N2d, P3d of the difference waves No-Go minus Go), and improved error processing, reflected in enhanced error-related components (Ne, Pe and Ne_d, Pe_d of the difference waves error minus correct trial). Our findings indicate that acute stress leads to a reallocation of cognitive resources, strengthening inhibition and error processing in young and older healthy men to a similar degree. Neural generators of the analyzed ERPs are mainly part of the salience network, which is upregulated immediately after stress. This offers an explanation as to why response inhibition, in contrast to other executive functions, improves after acute stress. [less ▲]

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See detailA Statistically Efficient Estimator for Co-array Based DoA Estimation
Sedighi, Saeid UL; Shankar, Bhavani UL; Ottersten, Björn UL

Poster (2018, October)

Co-array-based Direction of Arrival (DoA) estimation using Sparse linear arrays (SLAs) has recently gained considerable interest in array processing due to the attractive capability of providing enhanced ... [more ▼]

Co-array-based Direction of Arrival (DoA) estimation using Sparse linear arrays (SLAs) has recently gained considerable interest in array processing due to the attractive capability of providing enhanced degrees of freedom. Although a variety of estimators have been suggested in the literature for co-array-based DoA estimation, none of them are statistically efficient. This work introduces a novel Weighted Least Squares (WLS) estimator for the co-array-based DoA estimation employing the covariance fitting method. Then, an optimal weighting is given so that the asymptotic performance of the proposed WLS estimator coincides with the Cram\'{e}r-Rao Bound (CRB), thereby ensuring statistical efficiency of resulting WLS estimator. This implies that the proposed WLS estimator has significantly better performance compared to existing methods in the literature. Numerical simulations are provided to corroborate the asymptotic statistical efficiency and the improved performance of the proposed estimator. [less ▲]

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See detailREPRESENTING THE SOCIAL CHARACTER OF PLACES: ONTOLOGY MODELS OF THE URBAN ENVIRONMENT
Calafiore, Alessia UL

Doctoral thesis (2018)

The thesis aimed at rendering machine understandable the social dimension of urban places to provide a new generation of urban analytics based on peoples’ socio- spatial behaviour. The main outcome has ... [more ▼]

The thesis aimed at rendering machine understandable the social dimension of urban places to provide a new generation of urban analytics based on peoples’ socio- spatial behaviour. The main outcome has been a formal framework, encoded in the form of Ontology Design Patterns, to represent the interaction between the architectural aspects of the city, its form, and the behaviour of city dwellers. Ontology models are based on place theories discussed by social and cultural geographers - such as Henri Lefevbre, Edward Soja and Doreen Massey - and experimented in a knowledge discovery pipeline by exploring geographic crowdsourced data coming from the TripAdvisor platform. [less ▲]

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See detailFamily, migration and intergenerational solidarity - Discussion
Murdock, Elke UL

Scientific Conference (2018, September 06)

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See detailNumerical study on the load bearing capacity of a steel U section beam used as a formwork in constrcution stage
Turetta, Maxime UL; Khelil, Abdelouahab; Odenbreit, Christoph UL et al

Scientific Conference (2018, September 05)

For many categories of buildings, the structural elements must be fire resistant to allow people to evacuate and firefighters to intervene. A new type of steel-concrete composite solution dedicated to ... [more ▼]

For many categories of buildings, the structural elements must be fire resistant to allow people to evacuate and firefighters to intervene. A new type of steel-concrete composite solution dedicated to steel building structures is under development to resist against this fire situation. The solution is composed of a steel U section acting as a formwork for a reinforced concrete part that provides the fire resistance. In order to keep the habits of steel construction, the solution is unpropped in construction stage and the concrete is casted on site. Thus the solution has to resist against three majors situations: the construction stage without propping, the exploitation stage and the fire situation. The steel part of the composite beam is then designed to face the construction stage without propping. The present paper describes the numerical investigations carried out on the load bearing capacity of this steel section in construction stage. The objective of these investigations is to finally propose a steel solution stable and resistant for its use during construction stage. The numerical model of the steel section and its boundary conditions are presented. A first elastic calculation is used to determine the Eigen modes of the beam that give the shape of initials imperfections. Then analysis considering materials non-linearity and geometrical imperfections (GMNIA calculation) are carried out. A sensitivity study on the influence of the geometrical imperfections on the load bearing capacity of the beam is performed. Then, with the more conservative initial imperfection, a study on the global stability of the beam without any intermediate restraint is carried out. Finally, to overcome the problem of instability in construction stage, the restraint induced by the perpendicular steel decks is investigated. [less ▲]

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See detailControllability of transportation networks
Rinaldi, Marco UL; Viti, Francesco UL

Scientific Conference (2018, September)

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See detailDecompositions of the optimal dispatching problem of electric and electric-hybrid buses with energy constraints for Luxembourg City
Picarelli, Erika; Rinaldi, Marco UL; Viti, Francesco UL et al

Scientific Conference (2018, September)

We are a team of engineers working on a concrete project of Mobility in Luxembourg. We want to solve the problem of optimally determining the sequence of electric and hybrid electric buses, considering ... [more ▼]

We are a team of engineers working on a concrete project of Mobility in Luxembourg. We want to solve the problem of optimally determining the sequence of electric and hybrid electric buses, considering both service constraints (schedule adherence) and energy constraints (electric bus charging status, bus recharging scheduling in capacitated facilities) and at the same time ensure a high level of quality of service for the user satisfaction. The problem is formulated as a Mixed Integer Linear Program, with the objective of minimizing the total operational cost for the bus lines in question. System dynamics are captured by twenty sets of constraints, ranging from scheduling adherence to discharge-recharge dynamics. Individual operational costs at the bus level (cost of running an electric / non-electric bus per km, cost of recharging) and at the trip level (penalty due to failed schedule adherence) are fully parametrised, allowing for extensive sensitivity analysis. We investigate a real-life case study based in the city of Luxembourg, where the objective is to reach the all-electric mode for principal urban buses network. Through the model we investigate: the minimum amount of electric buses necessary to perform a day’s schedule for two currently partially electrified lines, without resorting to conventional internal combustion alternatives; the impact of electrifying two additional lines, specifically considering the trade-offs related to either adding new buses or new charging stations at the bus terminal. Finally, we studied how to best decompose the overall problem in several smaller problems, to be able to solve also realistic scenarios and using large real data sets from the Mobility Data owner of Luxembourg. We analysed and compared two kinds of decomposition: a bus line-based decomposition, and a time-based decomposition. [less ▲]

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See detailL’histoire des migrations revisitée
Camarda, Sandra UL; Scuto, Denis UL

in Scuto, Denis; Reuter, Antoinette (Eds.) Être d’ailleurs en temps de guerre (14-18). Etrangers à Dudelange/Dudelangeois à l’étranger. Catalogue d’exposition (2018)

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See detailE=K and nonepistemic percpetion
Hofmann, Frank UL

in Logos and Episteme: an International Journal of Epistemology (2018), IX(3), 307-31

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See detailIncorporating activity duration and scheduling utility into equilibrium-based Dynamic Traffic Assignment
Cantelmo, Guido UL; Viti, Francesco UL

in Transportation Research. Part B, Methodological (2018)

This paper deals with the problem of jointly modelling activity scheduling and duration within a Dynamic Traffic Assignment (DTA) problem framework. Although the last decades witnessed an intense effort ... [more ▼]

This paper deals with the problem of jointly modelling activity scheduling and duration within a Dynamic Traffic Assignment (DTA) problem framework. Although the last decades witnessed an intense effort in developing utility-based departure time choice models, relatively little has been done for understanding how the different assumptions on the utility model affect the model outputs. This problem is the main focus of this paper, which evaluates the effect of explicitly incorporating activity scheduling and duration within a generic user equilibrium DTA formulation. While using utility functions to model the positive component of the utility is a quite common procedure, the object of this paper is to show that a generic utility-based framework behaves as trip-based, activity-based, tour-based, or schedule-based if specific assumptions are specified. By establishing a set of properties, we quantify the amount of utility lost due to traffic congestion and how this affects activity (re-)scheduling and duration decisions. This allows predicting the effect of using a different assumption on the evolution of the transport system – and more specifically the departure time choice model. Conclusions support the idea that, under specific conditions, complex user behaviour can be approximated through a simplified model, and that the ratio between utility at origin and destination can be used to identify systematic biases within an existing DTA model – such as anticipating the rush hour. We also propose a novel utility function suited for modelling different activities, which can be used for modelling activities with a different duration. The mathematical model used to evaluate the effect of scheduling and duration into the equilibrium-based Dynamic Traffic Assignment is a simple bottleneck model. While this model has been recently re-formulated in order to capture the interaction between morning/evening commute, this paper further generalizes it in order to account for all type of activities. [less ▲]

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See detail"...der Weg ist natürlich ungemein viel schwieriger...". Leaving Care aus Sicht von Ehemaligen
Lunz, Marei UL; Strahl, Benjamin; Maschewski, Katharina

in Sozialmagazin (2018), 96(7-8), 96

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See detailLeaving Care als institutionalisierte Statuspassage und Übergangskonstellation – Einführende Gedanken zum Themenheft
Karl, Ute; Göbel, Sabrina UL; Herdtle, Anna-Marie UL et al

in Sozialmagazin (2018), 2018(7-8), 96

In dieser Ausgabe stellen Autor_innen aktuelle Befunde zu den Themen Übergänge aus der Heimerziehung und Vollzeitpflege vor, weiten den Blick auf die Nachbarländer Luxemburg und Schweiz aus und bieten ... [more ▼]

In dieser Ausgabe stellen Autor_innen aktuelle Befunde zu den Themen Übergänge aus der Heimerziehung und Vollzeitpflege vor, weiten den Blick auf die Nachbarländer Luxemburg und Schweiz aus und bieten Anschlüsse für eine Praxis, die Anregungen sucht, Anforderungen gelingend zu gestalten. Prozesse des Leaving Care und die Situation von Care Leaver_innen sind in den letzten Jahren zunehmend in den Fokus der öffentlichen Aufmerksamkeit gerückt. Im Zuge der Reformdebatte im Kinder- und Jugendhilferecht stellt sich für die professionelle Praxis mehr denn je die Frage, welche Herausforderungen sich daraus für die Arbeit mit jungen Erwachsenen im Übergang aus den Hilfesystemen ergeben. In dieser Ausgabe stellen Autor_innen aktuelle Befunde zu den Themen Übergänge aus der Heimerziehung und Vollzeitpflege vor, weiten den Blick auf Forschungsergebnisse aus den Nachbarländern Luxemburg und Schweiz aus und bieten neue Perspektiven und Anschlüsse für eine Praxis, die Anregungen sucht, Anforderungen gelingend zu gestalten. [less ▲]

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See detailÜbergänge aus der Heimerziehung in Luxemburg
Lunz, Marei UL; Jäger, Julia

in Sozialmagazin (2018)

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See detailLeaving Care
Karl, Ute; Göbel, Sabrina UL; Lunz, Marei UL et al

in Sozialmagazin (2018), 43(7-8), 96

Sozialmagazin 7-8/2018 Leaving Care In dieser Ausgabe stellen Autor_innen aktuelle Befunde zu den Themen Übergänge aus der Heimerziehung und Vollzeitpflege vor, weiten den Blick auf die Nachbarländer ... [more ▼]

Sozialmagazin 7-8/2018 Leaving Care In dieser Ausgabe stellen Autor_innen aktuelle Befunde zu den Themen Übergänge aus der Heimerziehung und Vollzeitpflege vor, weiten den Blick auf die Nachbarländer Luxemburg und Schweiz aus und bieten Anschlüsse für eine Praxis, die Anregungen sucht, Anforderungen gelingend zu gestalten. Prozesse des Leaving Care und die Situation von Care Leaver_innen sind in den letzten Jahren zunehmend in den Fokus der öffentlichen Aufmerksamkeit gerückt. Im Zuge der Reformdebatte im Kinder- und Jugendhilferecht stellt sich für die professionelle Praxis mehr denn je die Frage, welche Herausforderungen sich daraus für die Arbeit mit jungen Erwachsenen im Übergang aus den Hilfesystemen ergeben. In dieser Ausgabe stellen Autor_innen aktuelle Befunde zu den Themen Übergänge aus der Heimerziehung und Vollzeitpflege vor, weiten den Blick auf Forschungsergebnisse aus den Nachbarländern Luxemburg und Schweiz aus und bieten neue Perspektiven und Anschlüsse für eine Praxis, die Anregungen sucht, Anforderungen gelingend zu gestalten. [less ▲]

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