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See detailBlockPGP: A Blockchain-based Framework for PGP Key Servers
Yakubov, Alexander UL; Shbair, Wazen UL; State, Radu UL

in The Sixth International Symposium on Computing and Networking (2018, November 28)

Pretty Good Privacy (PGP) is one of the most prominent cryptographic standards, offering end-to-end encryption for email messages and other sensitive information. PGP allows to verify the identity of the ... [more ▼]

Pretty Good Privacy (PGP) is one of the most prominent cryptographic standards, offering end-to-end encryption for email messages and other sensitive information. PGP allows to verify the identity of the correspondent in information exchange as well as the information integrity. It implements asymmetric encryption with certificates shared through a network of PGP key servers. Many recent breaches show that certificate infrastructure can be compromised as well as exposed to operational errors. In this paper, we propose a new PGP management framework with the key server infrastructure implemented using blockchain technology. Our framework resolves some problems of PGP key servers focusing in particular on fast propagation of certificate revocation among key servers and elimination of man-in-the-middle risk. We also provided user access right control where only the certificate holder can change information related to the certificate. We designed and developed a prototype for key server deployment on permissioned Ethereum blockchain. Permissioned blockchain should allow to control the costs of PGP key server infrastructure maintenance at the present level. [less ▲]

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See detailEcological Advanced Driver Assistance System for Optimal Energy Management in Electric Vehicles
Sajadi Alamdari, Seyed Amin UL; Voos, Holger UL; Darouach, Mohamed

in IEEE Intelligent Transportation Systems Magazine (2018)

Battery Electric Vehicles have a high potential in modern transportation, however, they are facing limited cruising range. The driving style, the road geometries including slopes, curves, the static and ... [more ▼]

Battery Electric Vehicles have a high potential in modern transportation, however, they are facing limited cruising range. The driving style, the road geometries including slopes, curves, the static and dynamic traffic conditions such as speed limits and preceding vehicles have their share of energy consumption in the host electric vehicle. Optimal energy management based on a semi-autonomous ecological advanced driver assistance system can improve the longitudinal velocity regulation in a safe and energy-efficient driving strategy. The main contribution of this paper is the design of a real-time risk-sensitive nonlinear model predictive controller to plan the online cost-effective cruising velocity in a stochastic traffic environment. The basic idea is to measure the relevant states of the electric vehicle at runtime, and account for the road slopes, the upcoming curves, and the speed limit zones, as well as uncertainty in the preceding vehicle behavior to determine the energy-efficient velocity profile. Closed-loop Entropic Value-at-Risk as a coherent risk measure is introduced to quantify the risk involved in the system constraints violation. The obtained simulation and field experimental results demonstrate the effectiveness of the proposed method for a semi-autonomous electric vehicle in terms of safe and energy-efficient states regulation and constraints satisfaction. [less ▲]

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See detailÀ propos...
Scuto, Denis UL

Article for general public (2018)

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See detailIst Solfège gute Musik? Ein musikpädagogischer Ansatz zwischen Ästhetik und Selbstzweck
Sagrillo, Damien UL

Scientific Conference (2018, November 24)

Als Guido von Arezzo vor einem knappen Jahrtausend mit der Erfindung des Liniensystems aufwartete und Tonsilben aus den Angangsbuchstaben des Johannes-Hymnus ableitete, revolutionierte er damit die ... [more ▼]

Als Guido von Arezzo vor einem knappen Jahrtausend mit der Erfindung des Liniensystems aufwartete und Tonsilben aus den Angangsbuchstaben des Johannes-Hymnus ableitete, revolutionierte er damit die musikalische Bildung: Er ersetzte absurdes Auswendiglernen von (Kirchen-)Gesängen durch eine erlernbare, mechanische Lesetechnik. Er konnte wohl nicht ahnen, dass nach fast tausend Jahren „seine“ Methode immer noch Anwendung findet. In meinem Vortrag werde ich aufzeigen, wie Solfège, zum einen, durchaus musikästhetisch verortet ist, während, auf der anderen Seite, eben diese Methode der mechanischen Lesbarkeit, bar jedes musikästhetischen Anspruchs, den Musikpädagogen Kopfzerbrechen bereitet. [less ▲]

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See detailIntegration of omics data for biotechnology-relevant microbial communities
Herold, Malte UL

Doctoral thesis (2018)

Naturally occurring and artificial bacterial communities play an import role in many biotechnological processes. To elucidate bacterial interactions that are important for potential optimized ... [more ▼]

Naturally occurring and artificial bacterial communities play an import role in many biotechnological processes. To elucidate bacterial interactions that are important for potential optimized biotechnological applications, high-throughput measurements of biomolecules, metagenomics, metratranscriptomics,metaproteomics, and meta-metabolomics provide a detailed snapshot of mixed microbial consortia. Integration of multiple layers of omics data allows to reconstruct structure and function of complex microbial communities and is demonstrated for two different model systems. The first chapter focuses on synthetic communities consisting of strains representing key species found in biomining operations and acid mine drainage and that are of economical interest for copper production. A high-quality closed reference genome for L. ferriphilum was obtained by DNA sequencing and was subsequently used to integrate functional omics data, i.e. transcriptomic and proteomic profiling. The combination of genomics, genome annotation, and functional omics data allowed an in-depth characterization of L. ferriphilum in culture medium and in the presence of the iron sulfide mineral chalcopyrite, an economically relevant copper ore. Subsequently, analyses were performed for co-cultures of up to three organisms highlighting specific interaction mechanisms. The cultures without L. ferriphilum showed higher copper solubilisation rates, as the highly efficient iron oxidiser might raise the redox potential above the optimal range. For in situ studies, reference-based analyses are of limited use, e.g. due to a lack in reference genomes of culturable isolates. Hence, the second chapter focuses on an approach to study mixed microbial communities independent of prior knowledge and available reference genomes. A timeseries of oleaginous floating sludge samples that spans over one and a half years was analysed by integrating metagenomic, metatranscriptomic, metaproteomic, and meta-metabolomic data. This allowed the reconstruction of population level genomes and the characterization of the niches of the respective populations. The functional potential was assessed, as well as expression profiles over time, yielding a detailed view on lifestyle strategies and the potential impact of abiotic factors. Understanding the niche ecology of the predominant lipid accumulators in the system could lead towards optimized biofuel production. [less ▲]

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See detailExemplarische Bildungsverläufe von Jugendlichen in den Erziehungshilfen und im Übergang
Göbel, Sabrina UL

Scientific Conference (2018, November 08)

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See detailEntrepreneurial Teams, New Venture Direction and Growth: Evidence from Luxembourg
Tryba Geb. Fricke, Anne Karin UL

Doctoral thesis (2018)

New ventures can be an important driver of economic growth and technological progress. Yet, many new ventures fail and do not overcome the challenges of the early entrepreneurial phase. Extant research ... [more ▼]

New ventures can be an important driver of economic growth and technological progress. Yet, many new ventures fail and do not overcome the challenges of the early entrepreneurial phase. Extant research has acknowledged that the people who jointly start and manage a new venture have a key impact on its subsequent success and development. However, a discrepancy exists in how the interplay of their characteristics, cognition, and actions ultimately shape the way a new venture evolves. Therefore the primary purpose of this thesis is to contribute to this research stream by exploring the multifaceted role of entrepreneurial teams for new venture direction and growth. This is done with the aid of three research papers relying on a multiple case study and a specifically designed dataset from Luxembourg. The first paper illuminates how the shared pre-start-up transition moments of entrepreneurial team members influence the joint decision logic in the initial venture phase. Focusing on the composition of entrepreneurial teams, the second paper illustrates early activities that allow new ventures to leverage the diverse educational backgrounds of their team members to achieve financial growth. Lastly, the third paper explores aspects of leadership in new ventures and uncovers how agreement on an early shared vision affects subsequent changes in the entrepreneurial team, taking into account members’ relational ties. This thesis makes important contributions to research in entrepreneurship and strategic management, adding to a more fine-grained view on the micro-foundations and outcomes of entrepreneurial action. Also, it has practical implications for entrepreneurs, their mentors and investors, entrepreneurship education and policymakers. [less ▲]

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See detailFAST: A MapReduce Consensus for High Performance Blockchains
Khan, Nida UL

in Khan, Nida (Ed.) Proceedings of the 1st Workshop on Blockchain-enabled Networked Sensor Systems (2018, November 04)

Blockchain platforms when used as a database for IoT systems can resolve data reliability fault-tolerance, consistency and non-repudiation issues. However, their inherent shortcomings related to their ... [more ▼]

Blockchain platforms when used as a database for IoT systems can resolve data reliability fault-tolerance, consistency and non-repudiation issues. However, their inherent shortcomings related to their throughput in terms of processed transactions, limit their applicability in such environments in a decentralized way as the underlying network is unable to sustain high workloads. In this paper a fully decentralized high performance consensus mechanism, named FAST, is proposed for a public blockchain. FAST is based on mapreduce paradigm for aggregating and adding transactions on blockchain blocks. FAST was implemented and evaluated in a basic blockchain prototype. A light client for FAST using IPFS, was developed to bring about a reduction in the data stored locally. The obtained results from tests conducted on the prototype depict that FAST exceeds the performance of not just other existing blockchain platforms but comes very close to the throughput of traditional electronic payment networks such as Visa. [less ▲]

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See detailJustice spatiale - Poser la question du "Grand Luxembourg" en terme éthique
Evrard, Estelle UL

Article for general public (2018)

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See detailEuropean Union Funds
Pantazatou, Aikaterini UL

in Hofmann, Herwig; Rowe, Gerard; Türk, Alexander (Eds.) Specialized Administrative Law of the European Union: A Sectoral Review (2018)

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See detail"... bis wir eine eigene Schulzeitung in beiden Sprachen besitzen". Über die Entstehung und Bedeutung des Luxemburger Schulboten, 1844-1942
Voss, Peter UL

in Gardin, Matias; Lenz, Thomas (Eds.) Die Schule der Nation. Bildungsgeschichte und Identität in Luxemburg (2018)

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See detailWas ist ein Schurke (Shakespeare, "Richard III", Schiller, "Die Räuber")?
Kohns, Oliver UL

Presentation (2018, November)

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See detailSituative Interdisciplinarity: Empirical Reflections on Ten Years of Cross-Disciplinary Research
Reckinger, Rachel UL; Wille, Christian UL

in Academic Journal of Interdisciplinary Studies (2018), 7(3), 9-34

Given the current call for interdisciplinarity, we reflect on pragmatic methodological implementations of collaborative research – by drawing on empirical evidence from two large-scale cross-disciplinary ... [more ▼]

Given the current call for interdisciplinarity, we reflect on pragmatic methodological implementations of collaborative research – by drawing on empirical evidence from two large-scale cross-disciplinary research projects and by theoretically framing them in trilingual contexts (German, French, and English). These are two major innovations compared to the existing body of literature in this domain. Our empirical analysis shows that multi-, inter- or trans-disciplinary collaboration is an oscillating process along a spectrum of cross-disciplinarity – spanning additive, converging and synthesizing work patterns, i.e. multi-, inter-, and transdisciplinarity. Such an umbrella-term avoids the common amalgamation of ‘interdisciplinarity’ as the overarching category (cross-disciplinarity of whatever form) and one of the relevant subcategories (the specific work form that a research team chooses). Concretely, if the majority of methods are developed through communal negotiation processes, then a truly interdisciplinary analysis of research results can only be guaranteed through recursive self-reflexive loops. Initial research questions may still be additive and interactions can oscillate during the project process between addition und tentative convergence. We label this process situative interdisciplinarity. Multi-, inter- and transdisciplinarity are thus subsumed as a processual entity: flexible, possibly hybrid subforms of cross-disciplinarity. It needs constant reactivation, framing, timing and mediation by project managers. The major challenge lies in the collaborative transfer of concepts, theories, methods and research subjects. This transfer requires translation, explication and transposition of the various disciplinary ‘languages’ and can only be converged in an open-minded, team-oriented and reflexive work environment. [less ▲]

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See detailThe Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis
Hipp Epouse D'amico, Géraldine UL; Vaillant, Michel; Diederich, Nico J. et al

in Frontiers in Aging Neuroscience (2018), 10

While genetic advances have successfully defined part of the complexity in Parkinson’s disease (PD), the clinical characterization of phenotypes remains challenging. Therapeutic trials and cohort studies ... [more ▼]

While genetic advances have successfully defined part of the complexity in Parkinson’s disease (PD), the clinical characterization of phenotypes remains challenging. Therapeutic trials and cohort studies typically include patients with earlier disease stages and exclude comorbidities, thus ignoring a substantial part of the real-world PD population. To account for these limitations, we implemented the Luxembourg PD study as a comprehensive clinical, molecular and device-based approach including patients with typical PD and atypical parkinsonism, irrespective of their disease stage, age, comorbidities, or linguistic background. To provide a large, longitudinally followed, and deeply phenotyped set of patients and controls for clinical and fundamental research on PD, we implemented an open-source digital platform that can be harmonized with international PD cohort studies. Our interests also reflect Luxembourg-specific areas of PD research, including vision, gait, and cognition. This effort is flanked by comprehensive biosampling efforts assuring high quality and sustained availability of body liquids and tissue biopsies. We provide evidence for the feasibility of such a cohort program with deep phenotyping and high quality biosampling on parkinsonism in an environment with structural specificities and alert the international research community to our willingness to collaborate with other centers. The combination of advanced clinical phenotyping approaches including device-based assessment will create a comprehensive assessment of the disease and its variants, its interaction with comorbidities and its progression. We envision the Luxembourg Parkinson’s study as an important research platform for defining early diagnosis and progression markers that translate into stratified treatment approaches. [less ▲]

See detailWorkshop 'Strategies for Using Digital Sources in the Classroom
Randolph, John; Zaagsma, Gerben UL

Presentation (2018, October 26)

Given the current abundance of available digital resources for historians (retro-digitized as well as born-digital materials), there is an urgent question of how to engage with these resources in the ... [more ▼]

Given the current abundance of available digital resources for historians (retro-digitized as well as born-digital materials), there is an urgent question of how to engage with these resources in the history classroom. How do we teach the differences between "online" and "offline" materials and they ways in which historians can approach them? How do we deal with issues of decontextualization and the changes brought about in historical research practices by working with digital objects? The SourceLab project tackles these issues by letting students create digital editions of historical artefacts and thereby engage them in the making of history. The Ranke.2 project provides lessons that teaches students what digital source criticism is. In this workshop we will discuss in what ways teachers use digital resources in the classroom, and what strategies, if any, they use to sensitize their students to the specificities of online materials as opposed to those found in the archive. The outcome could be a working paper which discusses the pros and cons of various approaches. [less ▲]

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See detailCombining PET imaging and blood metabolomics data to improve machine learning models for Parkinson’s disease diagnosis
Glaab, Enrico UL; Trezzi, Jean-Pierre UL; Greuel et al

Poster (2018, October 08)

Objective: To investigate whether the integration of PET imaging and metabolomics data can provide improved machine learning models for PD diagnosis. Background: The reliable diagnosis of PD can remain ... [more ▼]

Objective: To investigate whether the integration of PET imaging and metabolomics data can provide improved machine learning models for PD diagnosis. Background: The reliable diagnosis of PD can remain challenging, even at the motor stage. PET imaging can be used to confirm the clinical diagnosis. However, limitations in the robustness of predictive features extracted from the data and the costs associated with PET imaging restrict its application. Using blood metabolomics data as an additional information source may provide improved combined diagnostic models and/or an initial filter to decide on whether to apply PET imaging. Methods: Metabolomics profiling of blood plasma samples using gas chromatography coupled to mass spectrometry (GC­MS) was conducted in 60 IPD patients and 15 healthy controls. After pre-processing, these data were compared to neuroimaging data for subsets of the same individuals using FDOPA PET (44 patients and 14 controls) and FDG PET (51 patients and 15 controls). Machine learning models using linear support vector machines were trained on 50% of the data and evaluated on a 50% hold­out test set using Receiver Operating Characteristic (ROC) curves. Next, standardized FDOPA and FDG PET intensity measurements were combined with those from the metabolomics data to build and evaluate sample classification models in the same manner as for the individual datasets. Results: Both for the FDOPA and FDG PET data, the predictive performance given by the area under the ROC curve (AUC) was highest when combining imaging features with those from the metabolomics data (AUC for FDOPA + metabolomics: 0.98; AUC for FDG + metabolomics: 0.91). The performance was generally lower when using only the respective PET attributes (FDOPA: 0.94, FDG: 0.8) or only the metabolomics data (AUC: 0.66). [less ▲]

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See detail(Dis-)Continuities and Disruptions in Young People’s Transitions out of Residential and Foster Care
Göbel, Sabrina UL

Scientific Conference (2018, October 05)

The project “TransCare. Young People's Transitions out of Residential and Foster Care” of the University of Luxembourg focuses on researching the achievement of agency in constellations of transitions ... [more ▼]

The project “TransCare. Young People's Transitions out of Residential and Foster Care” of the University of Luxembourg focuses on researching the achievement of agency in constellations of transitions. One part of the project sheds a light on former care leaver’s perspectives on their transition processes out of institutional care settings. Therefore, it looks at the experiences of young people themselves.The retrospective and biographical interviews with people who had left the care system, three to seven years ago, give us the opportunity to reconstruct different forms and patterns of transition. On closer inspection, the analysis of the interviews reveals many disruptions, discontinuities, turning points and overlays in the trajectories of the young people already within the care system. There are multiple breaks that influence transitions in other systems, e.g. in the system of education. This leads to various challenges and uncertainties that respondents face. Moreover, in phases of transition specific constructions and changes of affiliation/belongings appear to be handled by the young people. The biographical approach shows in which dimensions young people positioning themselves towards their own person and the institutional setting. It also illustrates in which ways the former care leavers experience themselves in various ways as agentic subjects in their transitions and which conditions and resources play a role in this process of leaving an institutional organized setting. By contrasting the interviews, the reconstructive analysis reveals the relevance of belongings and social relations in leaving care processes. It is asking “how, in a context of increasingly fluid, unstable and mobile lives, young people build meaning through their connections with people and places over time” (Cuervo & Wyn 2017, p. 220) and how different ways and forms of agency are achieved during transition processes. [less ▲]

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