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See detailPrivacy-preserving KYC on Ethereum
Biryukov, Alex UL; Khovratovich, Dmitry; Tikhomirov, Sergei UL

Scientific Conference (2018, May 09)

Identity is a fundamental concept for the financial industry. In order to comply with regulation, financial institutions must verify the identity of their customers. Identities are currently handled in a ... [more ▼]

Identity is a fundamental concept for the financial industry. In order to comply with regulation, financial institutions must verify the identity of their customers. Identities are currently handled in a centralized way, which diminishes users' control over their personal information and threats their privacy. Blockchain systems, especially those with support for smart contracts (e.g.,~Ethereum), are expected to serve as a basis of more decentralized systems for digital identity management. We propose a design of a privacy-preserving KYC scheme on top of Ethereum. It would let providers of financial services leverage the potential of blockchain technology to increase efficiency of customer onboarding while complying with regulation and protecting users' privacy. [less ▲]

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See detailDevelopment of mass spectrometry-based assays to measure the ERCC1/XPF proteins as potential biomarkers in lung cancer
Antonelli, Daniela UL

Doctoral thesis (2018)

In the last two decades, the integration of personalized medicine approaches in the management of oncology patients has led to important progress. Indeed, the use of predictive biomarkers in clinical ... [more ▼]

In the last two decades, the integration of personalized medicine approaches in the management of oncology patients has led to important progress. Indeed, the use of predictive biomarkers in clinical practice to improve treatment strategies has represented an important achievement for both patient clinical outcomes and quality of medical care. In the context of lung cancer, several studies have highlighted a potential role of the excision repair cross-complementation group 1 (ERCC1) protein as a predictive biomarker of platinum-based chemotherapy efficacy in the treatment of non-small cell lung cancer (NSCLC) patients. ERCC1 protein and its binding partner, the DNA repair endonuclease XPF, are key players in the nucleotide excision repair (NER) pathway where they repair DNA lesions caused by platinum-based drugs. However, the presence of four ERCC1 isoforms, of which only one, ERCC1-202, is functional in the NER pathway, complicates the clinical scenario. Indeed, the lack of an antibody that specifically recognizes ERCC1-202 hampers the development of a valid clinical assay to assist clinicians in therapeutic decision making. Moreover, the essential nature of the ERCC1/XPF interaction to repair DNA lesions, suggested the pivotal role of the ERCC1/XPF complex in the prediction of therapy response. Because of the need to discriminate among the four ERCC1 isoforms, to selectively quantify ERCC1-202 in an antibody-independent fashion, and because of the required contribution of the XPF protein in the DNA lesion processing, the present project aimed to develop robust mass spectrometry (MS)-based assays for the ERCC1 and XPF isoforms to provide accurate quantification of the ERCC1-202/XPF proteins as binding partners. Combining ERCC1 or XPF immunoenrichment from biological samples with targeted mass spectrometry, the selected ERCC1 and XPF proteotypic peptides (PTPs) were measured by parallel reaction monitoring (PRM) using a quadrupole-obitrap mass spectrometer. The quantification of the ERCC1-202/XPF proteins was performed using stable isotope labeled (SIL) peptides. The associated results showed that the simultaneous detection of three ERCC1 PTPs, named isoform discriminating peptides, represents a signature of ERCC1-202 and that the inclusion of control peptides allows to avoide ERCC1 isoform misclassification. The immuno-affinity studies and the evaluation of XPF stability highlighted that ERCC1-202 interacts and stabilizes XPF. Finally, a correlation between ERCC1-202/XPF protein levels was observed. In the light of the poor analytic specificity of the current immunohistochemistry (IHC) assay for the ERCC1 protein, the use of targeted MS-based assays to detect and quantify both ERCC1-202 and XPF proteins represents a more selective approach. These findings strongly suggest to assess the role of the ERCC1-202/XPF proteins as predictive biomarkers in clinical samples with the final goal to guide the clinicians’ therapeutic decisions. [less ▲]

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See detailBrexit and the battle for financial services
Howarth, David UL; Quaglia, Lucial

in Journal of European Public Policy (2018), 25(8), 1118-1136

This paper analyses the policy developments concerning the Single Market in finance in the context of Brexit. Theoretically, we engage with two bodies of work that make contrasting predictions on European ... [more ▼]

This paper analyses the policy developments concerning the Single Market in finance in the context of Brexit. Theoretically, we engage with two bodies of work that make contrasting predictions on European financial market integration and the development of European Union (EU)policies on financial regulation: on focused upon a neo-mercantilist ‘battle’ amongst member states and the other stressing the importance of transnational financial networks (or coalitions). Empirically, we find limited evidence of the formation of crossnational alliances in favour of the United Kingdom (UK) retaining broad access to the EU Single Market in financial services, the presence of which would have aligned with the expectations of analyses focused upon transnational networks. By contrast, the main financial centres in the EU27 and their national authorities competed to lure financial business away from the UK — what we explain in terms of a ‘battle’ amongst member states and their national financial centres. [less ▲]

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See detailInnovation in Outer Space: International and African Legal Perspective
Hofmann, Mahulena UL; Blount, Percy UL

Book published by Nomos/ Hart - 1st (2018)

The innovation of technology connected with the use of outer space and telecommunication require new approaches to the present international space law and telecommunications law. Specific attention is ... [more ▼]

The innovation of technology connected with the use of outer space and telecommunication require new approaches to the present international space law and telecommunications law. Specific attention is devoted to the space and telecommunication legislation in the countries of the African continent. [less ▲]

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See detailSpace Resources: Regulatory Aspects
Hofmann, Mahulena UL

in Hofmann, Mahulena; Blount, Percy (Eds.) Innovation in Outer Space: International and African Legal Perspectives (2018)

Space Resources activities are expanding. The US and Luxembourg adopted national legislation enabling their authorization. The chapter discusses the international legal framework of space resources ... [more ▼]

Space Resources activities are expanding. The US and Luxembourg adopted national legislation enabling their authorization. The chapter discusses the international legal framework of space resources activities, and their reflect in national US and Luxembourg legislation. [less ▲]

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See detail"Chosen Fighters of the Jewish People": Jewish volunteers in the International Brigades during the Spanish Civil War
Zaagsma, Gerben UL

Presentation (2018, April 05)

During the Spanish Civil War (1936-1939) around 35000 volunteers from many countries fought in the so-called International Brigades that were created and organised by the Communist International. Roughly ... [more ▼]

During the Spanish Civil War (1936-1939) around 35000 volunteers from many countries fought in the so-called International Brigades that were created and organised by the Communist International. Roughly 4000 of these volunteers were of Jewish descent. In december 1937, the Jewish Naftali Botwin company was formed within the 13th Polish Dombrowski Brigade as a result of lobbying efforts by Polish-Jewish migrant communists in Paris. In their daily newspaper, Naye Prese, the company’s existence became an important part of the propaganda battle waged on the ‘Jewish street’ in Paris in support of the Comintern’s post-1935 Popular Front tactic. But while the propaganda was unmistakably communist, the subtext became increasingly Jewish in the course of the war. Indeed, against a background of age-old allegations of ‘Jewish cowardice’, Naye Prese consistently emphasised that the fight of Jewish volunteers, symbolised by the Botwin Company, had an emancipatory dimension: Jews were worthy and equal fighters. Their participation simultaneously served as a model of Jewish action to be emulated by Jewish migrants in France as they sought to negotiate increasingly difficult living circumstances. After World War II and the Holocaust, the memory of Jewish volunteers became decisively shaped by debates on Jewish responses to fascism and Nazism; their participation was inscribed in a broader narrative of Jewish resistance that aimed to counter the myth of Jewish passivity in the face of the Nazi onslaught. To put it succinctly: ‘Spain’ served to prove that Jews did not go like “sheep to the slaughter” but already resisted Hitler in Spain. Based upon my scholarship on Jewish volunteers in the International Brigades, the aim of this paper, then, is to analyze the symbolic meaning of their participation, and show the various ways in which the qualification ‘Jewish’ was and has been imbued with meaning, both during and after the Spanish Civil War. Ultimately, I will show how volunteers of Jewish descent during the Spanish Civil War became Jewish volunteers after the Holocaust. [less ▲]

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See detailEnabling lock-free concurrent workers over temporal graphs composed of multiple time-series
Fouquet, Francois; Hartmann, Thomas UL; Mosser, Sébastien

in 33rd Annual ACM Symposium on Applied Computing (SAC'18) (2018, April)

Time series are commonly used to store temporal data, e.g., sensor measurements. However, when it comes to complex analytics and learning tasks, these measurements have to be combined with structural ... [more ▼]

Time series are commonly used to store temporal data, e.g., sensor measurements. However, when it comes to complex analytics and learning tasks, these measurements have to be combined with structural context data. Temporal graphs, connecting multiple time- series, have proven to be very suitable to organize such data and ultimately empower analytic algorithms. Computationally intensive tasks often need to be distributed and parallelized among different workers. For tasks that cannot be split into independent parts, several workers have to concurrently read and update these shared temporal graphs. This leads to inconsistency risks, especially in the case of frequent updates. Distributed locks can mitigate these risks but come with a very high-performance cost. In this paper, we present a lock-free approach allowing to concurrently modify temporal graphs. Our approach is based on a composition operator able to do online reconciliation of concurrent modifications of temporal graphs. We evaluate the efficiency and scalability of our approach compared to lock-based approaches. [less ▲]

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See detailL’aménagement du territoire transfrontalier en pratique: Réflexions pour un dialogue entre chercheurs et praticiens de la Grande Région
Bechtold, Joshua; Caesar, Beate; Christmann, Nathalie UL et al

Diverse speeches and writings (2018)

Avec une coopération initiée dans les années 1970, la Grande Région est considérée comme l’un des espaces transfrontaliers les plus emblématiques au sein de l’Union européenne. L’aménagement du territoire ... [more ▼]

Avec une coopération initiée dans les années 1970, la Grande Région est considérée comme l’un des espaces transfrontaliers les plus emblématiques au sein de l’Union européenne. L’aménagement du territoire constitue un élément essentiel de ses thématiques de coopération. Cependant, l'importance grandissante de ce champ d'action demeure relativement peu documentée d'un point de vue transfrontalier. Cette thématique reste principalement abordée sous l’angle réglementaire et institutionnel. Le présent policy paper postule qu’au-delà des règlementations, des plans et des schémas, l’aménagement du territoire transfrontalier résulte également d’une pratique visant à anticiper l’organisation d’une société dans un espace donné. Après une présentation sommaire des grandes étapes de la coopération dans le domaine de l’aménagement du territoire transfrontalier au sein de la Grande Région, le présent policy paper présente les résultats d’un exercice de recherche expérimentale réalisé en 2017, essentiellement sous la forme d’un jeu de simulation (« Planspiel »). Les principales conclusions analytiques de cet échange sont ensuite mises en lumière. Pour conclure, le document dresse une liste de recommandations basées sur l’analyse des résultats des travaux de recherche. [less ▲]

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See detailPhase-field predictive model for setting of fresh self-compacting concrete
Huang, Haiqin UL; Zilian, Andreas UL

Scientific Conference (2018, March)

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See detailINVESTIGATION OF THE CU(SN,GE)S3 TERNARY ALLOY FOR THIN FILM SOLAR CELLS
Robert, Erika UL

Doctoral thesis (2018)

This thesis examines material properties of the novel Cu2(Sn, Ge)S3 alloy, from the perspective of a solar cell scientist searching for a new light absorbing material to produce highly efficient thin-film ... [more ▼]

This thesis examines material properties of the novel Cu2(Sn, Ge)S3 alloy, from the perspective of a solar cell scientist searching for a new light absorbing material to produce highly efficient thin-film devices. [less ▲]

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See detailOpinion Statement ECJ-TF 3/2017 on the Decision of the Court of Justice of the European Union of 16 May 2017 in Berlioz Investment Fund SA (Case C-682/15), Concerning the Right to Judicial Review under Article 47 of the EU Charter of Fundamental Rights in Cases of Cross-Border Mutual Assistance in Tax Matters
Haslehner, Werner UL; García Prats, Alfredo; Heydt, Volker et al

in European Taxation (2018)

The CFE welcomes this decision in that it marks a new page in the protection of taxpayer rights. In line with the principle “wherever there is a right, there is a remedy”, it shows that EU law may ... [more ▼]

The CFE welcomes this decision in that it marks a new page in the protection of taxpayer rights. In line with the principle “wherever there is a right, there is a remedy”, it shows that EU law may reconcile the interest in securing an effective protection of tax collection with that in respecting fundamental rights. The CFE wonders whether the threshold of “manifest irrelevance” can effectively secure the protection of the relevant persons’ rights. It also wonders whether this offers an effective protection against fishing expeditions or requests for information that is unlikely to be relevant to the tax affairs of a given taxpayer. [less ▲]

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See detailDéveloppement d’un test de compétences numériques précoces destiné à mesurer les effets d’une intervention mise en place auprès d’élèves de 4 à 6 ans
de Chambrier, Anne-Françoise; Vlassis, Joëlle UL; Fagnant, Annick et al

Scientific Conference (2018, January)

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See detailLand of the Red Soil: War Ruins and Industrial Landscape in Luxembourg
Camarda, Sandra UL

in Daly, Selena; Salvante, Martina; Wilcox, Vanda (Eds.) Landscapes of the First World War (2018)

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See detailTowards a Roadmap for Privacy Technologies and the General Data Protection Regulation : A transatlantic initiative
Schiffner, Stefan UL; Berendt, Bettina; Siil, Triin et al

in Tsouroulas, Nikolaos; Rannenberg, Kai; Medina, Manel (Eds.) proceedings of the Annual Privacy Forum 2018 (2018)

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See detailAccurate filtering of privacy-sensitive information in raw genomic data
Decouchant, Jérémie UL; Fernandes, Maria UL; Volp, Marcus UL et al

in Journal of Biomedical Informatics (2018)

Sequencing thousands of human genomes has enabled breakthroughs in many areas, among them precision medicine, the study of rare diseases, and forensics. However, mass collection of such sensitive data ... [more ▼]

Sequencing thousands of human genomes has enabled breakthroughs in many areas, among them precision medicine, the study of rare diseases, and forensics. However, mass collection of such sensitive data entails enormous risks if not protected to the highest standards. In this article, we follow the position and argue that post-alignment privacy is not enough and that data should be automatically protected as early as possible in the genomics workflow, ideally immediately after the data is produced. We show that a previous approach for filtering short reads cannot extend to long reads and present a novel filtering approach that classifies raw genomic data (i.e., whose location and content is not yet determined) into privacy-sensitive (i.e., more affected by a successful privacy attack) and non-privacy-sensitive information. Such a classification allows the fine-grained and automated adjustment of protective measures to mitigate the possible consequences of exposure, in particular when relying on public clouds. We present the first filter that can be indistinctly applied to reads of any length, i.e., making it usable with any recent or future sequencing technologies. The filter is accurate, in the sense that it detects all known sensitive nucleotides except those located in highly variable regions (less than 10 nucleotides remain undetected per genome instead of 100,000 in previous works). It has far less false positives than previously known methods (10% instead of 60%) and can detect sensitive nucleotides despite sequencing errors (86% detected instead of 56% with 2% of mutations). Finally, practical experiments demonstrate high performance, both in terms of throughput and memory consumption. [less ▲]

Detailed reference viewed: 24 (1 UL)