Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailRandomised controlled non-inferiority trial of primary care-based facilitated access to an alcohol reduction website
Wallace, Paul; Struzzo, Pierliugi; Della Vedova, Roberto et al

in BMJ Open (2017), 7(11),

Background: Brief interventions (BIs) delivered in primary care have been shown to be effective in reducing risky drinking, but implementation is limited. Facilitated access to a digital application ... [more ▼]

Background: Brief interventions (BIs) delivered in primary care have been shown to be effective in reducing risky drinking, but implementation is limited. Facilitated access to a digital application offers a novel alternative to face-to-face intervention, but its relative effectiveness is unknown.Methods: Primary care-based, non-inferiority, randomised controlled trial comparing general practitioner (GP) facilitated access to an interactive alcohol reduction website (FA) with face-to-face BI for risky drinking. Patients screening positive on the short Alcohol Use Disorders Identification Test (AUDIT-C) were invited to participate in the trial. Assessment at baseline, 3 months and 12 months was carried out using AUDIT and EQ-5D-5L questionnaires. Findings: 58 participating GPs approached 9080 patients of whom 4529 (49.9%) logged on, 3841 (84.8%) undertook screening, 822 (21.4%) screened positive and 763 (19.9%) were recruited. 347 (45.5%) were allocated to FA and 416 (54.5%) to BI. At 3 months, subjects in FA group with an AUDIT score of ≥8 reduced from 95 (27.5%) to 85 (26.8%) while those in BI group increased from 123 (20.6%) to 141 (37%). Differences between groups were principally due to responses to AUDIT question 10. Analysis of primary outcome indicated non-inferiority of FA compared with BI, and prespecified subgroup analysis indicated benefits for older patients and those with higher levels of computer literacy and lower baseline severity. Additional analyses undertaken to take account of bias in response to AUDIT question 10 failed to support non-inferiority within the prespecified 10% boundary.Interpretation: Prespecified protocol-driven analyses of the trial indicate that FA is non-inferior to BI; however, identified bias in the outcome measure and further supportive analyses question the robustness of this finding. It is therefore not possible to draw firm conclusions from this trial, and further research is needed to determine whether the findings can be replicated using more robust outcome measures.Trial registration number NCT01638338; Results. [less ▲]

Detailed reference viewed: 12 (2 UL)
Full Text
Peer Reviewed
See detailMetaphors in Digital Hermeneutics: Zooming through Literary, Didactic and Historical Representations of Imaginary and Existing Cities
Armaselu, Florentina UL; van den Heuvel, Charles

in Digital Humanities Quarterly (2017), 11(3),

The paper proposes to bridge two areas of inquiry, digital hermeneutics and metaphor within a digital environment, by the analysis of a less studied phenomenon, i.e. how interpretation is supported and ... [more ▼]

The paper proposes to bridge two areas of inquiry, digital hermeneutics and metaphor within a digital environment, by the analysis of a less studied phenomenon, i.e. how interpretation is supported and shaped by metaphors embedded in an interface. The study is articulated around three use cases for literary, didactic and historical representations of imaginary and existing cities based on a model (z-text) and interface (Z-editor) for zoomable texts. We will try to demonstrate that the zooming and contextualization features of the tool allow creating layers of meaning that can assist interpretation and critical readings of literature and history. [less ▲]

Detailed reference viewed: 18 (9 UL)
See detailKontaktraum für die einen, Filter für die anderen
Nienaber, Birte UL

Article for general public (2017)

Detailed reference viewed: 6 (0 UL)
Peer Reviewed
See detailBischof, Bürger und Hospital. Städtische Autonomie und bischöfliche Präsenz
Pauly, Michel UL

in Bihrer, Andreas; Fouquet, Gerhard (Eds.) Bischofsstadt ohne Bischof? Präsenz, Interaktion und Hoforganisation in bischöflichen Städten des Mittelalters (1300-1600) (2017)

Detailed reference viewed: 6 (0 UL)
See detailIm Reich der spitzen Töne. Willy Mommer jun. (1921-1972): Musiker, Spion, Kulturmanager
Mommer, Marie-Claire; Brüll, Christoph UL

Book published by Grenz-Echo (2017)

Willy Mommer jun. (1921-1972), eminenter Vertreter der wohl bedeutendsten Eupener Musikerfamilie, erlangte als Dirigent, Komponist und Kulturmanager internationale Ausstrahlung. Doch hinter dem Künstler ... [more ▼]

Willy Mommer jun. (1921-1972), eminenter Vertreter der wohl bedeutendsten Eupener Musikerfamilie, erlangte als Dirigent, Komponist und Kulturmanager internationale Ausstrahlung. Doch hinter dem Künstler verbirgt sich auch eine der spannendsten Kriegsbiografien unserer Region. Als Funker beim deutschen militärischen Nachrichtendienst („Abwehr“) in Münster, Köln und Belzig bei Berlin konnte er sich durch seine pianistische Meisterschaft Zugang zum höchsten Machtzirkel des Militärs verschaffen und auf diese Weise den belgischen Widerstand und die britischen Nachrichtendienste mit kriegswichtigen Informationen versorgen. Marie-Claire Mommer und Christoph Brüll suchen in diesem Buch nach Spuren aus dem Leben Willy Mommers und verarbeiten sie zu einer literarischen und historischen Annäherung an eine Grenzen überschreitende Persönlichkeit und an einen leidenschaftlichen Europäer. [less ▲]

Detailed reference viewed: 19 (1 UL)
Full Text
Peer Reviewed
See detailCompetition between crystal and fibril formation in molecular mutations of amyloidogenic peptides
Reynolds, Nicholas; Adamcik, Jozef; Berryman, Josh UL et al

in Nature Communications (2017), 8

Amyloidogenic model peptides are invaluable for investigating assembly mechanisms in disease related amyloids and in protein folding. During aggregation, such peptides can undergo bifurcation leading to ... [more ▼]

Amyloidogenic model peptides are invaluable for investigating assembly mechanisms in disease related amyloids and in protein folding. During aggregation, such peptides can undergo bifurcation leading to fibrils or crystals, however the mechanisms of fibril-to-crystal conversion are unclear. We navigate herein the energy landscape of amyloidogenic peptides by studying a homologous series of hexapeptides found in animal, human and disease related proteins. We observe fibril-to-crystal conversion occurring within single aggregates via untwisting of twisted ribbon fibrils possessing saddle-like curvature and cross-sectional aspect ratios approaching unity. Changing sequence, pH or concentration shifts the growth towards larger aspect ratio species assembling into stable helical ribbons possessing mean-curvature. By comparing atomistic calculations of desolvation energies for association of peptides we parameterise a kinetic model, providing a physical explanation of fibril-to-crystal interconversion. These results shed light on the self-assembly of amyloidogenic peptides, suggesting amyloid crystals, not fibrils, represent the ground state of the protein folding energy landscape. [less ▲]

Detailed reference viewed: 6 (2 UL)
Full Text
Peer Reviewed
See detailRandomised controlled non-inferiority trial of primary care-based facilitated access to an alcohol reduction website: cost-effectiveness analysis
Hunter, Rachael; Wallace, Paul; Struzzo, Pierluigi et al

in BMJ Open (2017), 7(11),

Objectives To evaluate the 12-month costs and quality-adjusted life years (QALYs) gained to the Italian National Health Service of facilitated access to a website for hazardous drinkers compared with a ... [more ▼]

Objectives To evaluate the 12-month costs and quality-adjusted life years (QALYs) gained to the Italian National Health Service of facilitated access to a website for hazardous drinkers compared with a standard face-to-face brief intervention (BI). Design Randomised 1:1 non-inferiority trial. Setting Practices of 58 general practitioners (GPs) in Italy. Participants Of 9080 patients (>18 years old) approached to take part in the trial, 4529 (49·9%) logged on to the website and 3841 (84.8%) undertook online screening for hazardous drinking. 822 (21.4%) screened positive and 763 (19.9%) were recruited to the trial. Interventions Patients were randomised to receive either a face-to-face BI or access via a brochure from their GP to an alcohol reduction website (facilitated access). Primary and secondary outcome measures The primary outcome is the cost per QALY gained of facilitated access compared with face-to-face. A secondary analysis includes total costs and benefits per 100 patients, including number of hazardous drinkers prevented at 12 months. Results The average time required for the face-to-face BI was 8 min (95% CI 7.5 min to 8.6 min). Given the maximum time taken for facilitated access of 5 min, face-to-face is an additional 3 min: equivalent to having time for another GP appointment for every three patients referred to the website. Complete case analysis adjusting for baseline the difference in QALYs for facilitated access is 0.002 QALYs per patient (95% CI −0.007 to 0.011). Conclusions Facilitated access to a website to reduce hazardous drinking costs less than a face-to-face BI given by a GP with no worse outcomes. The lower cost of facilitated access, particularly in regards to investment of time, may facilitate the increase in provision of BIs for hazardous drinking. Trial registration number NCT01638338;Post-results. [less ▲]

Detailed reference viewed: 5 (0 UL)
Full Text
Peer Reviewed
See detailLuxembourg National Report: Tax Avoidance Revisited in the EU BEPS Context
Haslehner, Werner UL

in Dourado, Ana Paula (Ed.) Tax Avoidance Revisited in the EU BEPS Context (2017)

This contribution analyses the status quo of anti-tax avoidance laws and doctrines in Luxembourg in reflection of the developments from the OECD BEPS project and the EU's reaction thereto. Starting from ... [more ▼]

This contribution analyses the status quo of anti-tax avoidance laws and doctrines in Luxembourg in reflection of the developments from the OECD BEPS project and the EU's reaction thereto. Starting from the traditional approach taken by the Luxembourg courts to the term "Steuerumgehung" in §6 StAnpG, it also refers to special and target anti-avoidance rules (SAARs and TAARs) notably in the area of transfer pricing. Please note that the contribution was finalised in summer 2016 and the initial temporal scope of the study had been set until the end of 2015. Later developments, in particular changes to transfer pricing in Luxembourg (Art. 56bis LIR) could therefore not be taken into account. [less ▲]

Detailed reference viewed: 16 (3 UL)
Full Text
Peer Reviewed
See detailBesteuerung der digitalen Wirtschaft in Großbritannien, Italien und Ungarn - ein europäischer Rechtsvergleich
Sinnig, Julia UL

in Internationale Steuer-Rundschau : Zeitschrift für Internationales Steuerrecht (2017), 6(11), 408-413

The "digital economy", a well-established notion in international tax law, is problematic for national legislatures and causes concern in the realm of international administrative assistance. At issue is ... [more ▼]

The "digital economy", a well-established notion in international tax law, is problematic for national legislatures and causes concern in the realm of international administrative assistance. At issue is the fundamental basis of the jurisdiction to tax: the genuine link between income generated by a digital business model and a specific territory, which is not easily identifiable under existing international tax concepts and far from digital economic reality. Multinational digital enterprises, however, are especially able to benefit from tax planning strategies that are even more favored by outdated international tax concepts. Negotiations and efforts to find international consensus on adaptations of existing tax concepts to intangible business models have been lengthy and so far unsuccessful. Consequently, recently some States have begun implementing unilateral measures to modernise digital economy taxation. This note presents the solutions of the United Kingdom, Italy and Hungary to adapt their income tax systems to the digital economy. [less ▲]

Detailed reference viewed: 8 (0 UL)
See detailCEN/TC250/SC4.T1: Second Generation of Eurocode 4: Introduction and Amendments to Final Draft October 2017
Banfi, Mike; Mensinger, Martin; Schäfer, Markus UL et al

Report (2017)

Development of second Generation of Eurocode 4, Projectteam CEN/TC250/SC4/T1, Reports for final Draft October 2017

Detailed reference viewed: 9 (3 UL)
See detailEinleitung
Fickers, Andreas UL; Haude, Rüdiger; Krebs, Stefan UL et al

in Fickers, Andreas; Haude, Rüdiger; Krebs, Stefan (Eds.) et al Jeux sans Frontières? - Grenzgänge der Geschichtswissenschaft (2017)

Detailed reference viewed: 12 (4 UL)
See detail"Glanz und Elend der Kunstkopf-Stereophonie": Eine technik- und medienarchäologische Ausgrabung
Krebs, Stefan UL

in Fickers, Andreas; Haude, Rüdiger; Krebs, Stefan (Eds.) et al Jeux sans Frontières? - Grenzgänge der Geschichtswissenschaft (2017)

Detailed reference viewed: 7 (2 UL)
Full Text
Peer Reviewed
See detailFatigue of rocks
Pytlik, Robert Stanislaw UL; Van Baars, Stefan UL

in Johansson, Erik; Raasakka, Ville (Eds.) Proceedings of the 3rd Nordic Rock Mechanics Symposium, NRMS 2017 (2017, November)

Cyclic loading on civil structures can lead to a reduction of strength of the used materials. For the materials concrete and especially steel, there are clear design codes about how to account for the ... [more ▼]

Cyclic loading on civil structures can lead to a reduction of strength of the used materials. For the materials concrete and especially steel, there are clear design codes about how to account for the reduction of the material shear strength due to this cyclic loading, which is called fatigue. For the material rock, however, there are no design codes or standards for fatigue, in terms of shear strength reduction. For this reason, a large number of laboratory triaxial tests have been performed, in order to evaluate the fatigue of rocks by comparing the shear strength parameters obtained in cyclic triaxial tests with the static shear strength. Tests have been performed on artificial gypsum, a mixture of sand and cement (mortar) and soft sedimentary limestone. Correlations of the fatigue, for both the number of cycles and the cyclic stress ratio, have been obtained. All triaxial tests were conducted on dry samples (no pore pressure) in the natural state. The range of the confining pressure was between 0 MPa and 0.5 MPa. The frequency was kept low to allow for a precise application of the cyclic load and also accurate readings. The number of applied cycles was from a few cycles up to a few hundred thousand. The imperfections in the artificial gypsum have a significant impact on the results of the (especially cyclic) strength tests. Therefore another man made material was used – a mixture of sand and cement (mortar). As the first static test results were very promising, mortar was used in further tests. The cyclic tests, however, presented a similar, high scatter of results as for artificial gypsum. Due to the complex behaviour of the cohesive materials and high scatter of the results, many tests were required. Two different strategies were used to investigate the fatigue of the cohesive geomaterials: 1. the remaining shear strength curve: after a given number of cycles, a final single load test until failure, measures the remaining shear strength of the sample. 2. the typical S-N curve (Wöhler curves): one counts the number of constant loading cycles until failure. The fatigue of rocks can be seen as a reduction of the cohesion. In this way, the fatigue of a cohesive geomaterial can be described by (a reduction of) the remaining cohesion. An unexpected observation for both artificial gypsum and mortar was that unlike the number of cycles, the size of the cyclic stress ratio has little influence on the remaining shear strength, and therefore on fatigue. The remaining shear strength (or strength reduction) curve has been compared with the standard S-N curve, and is found to be rather similar for both artificial gypsum and mortar. The reason for this is this unexpected observation. Because of this, the S-N curve and the remaining shear strength curve should be theoretically identical. The results of the triaxial tests show however that, the S-N curve gives a bit steeper slope than the remaining shear strength curve, which would imply a shorter life and a faster reduction in comparison to the remaining shear strength curve, but this is only because, the prematurely failed samples are not included in the remaining shear strength curve, while a significant number of the S-N samples are prematurely failed samples from the remaining shear strength tests. [less ▲]

Detailed reference viewed: 7 (0 UL)
See detailJeux sans Frontières? - Grenzgänge der Geschichtswissenschaft
Fickers, Andreas UL; Haude, Rüdiger; Krebs, Stefan UL et al

Book published by transcript (2017)

Detailed reference viewed: 18 (4 UL)
Full Text
Peer Reviewed
See detailDNA partitions into triplets under tension in the presence of organic cations, with sequence evolutionary age predicting the stability of the triplet phase
Taghavi, Amirhossein UL; van der Schoot, Paul; Berryman, Josh UL

in Quarterly Reviews of Biophysics (2017), 50

Using atomistic simulations, we show the formation of stable triplet structure when particular GC-rich DNA duplexes are extended in solution over a timescale of hundreds of nanoseconds, in the presence of ... [more ▼]

Using atomistic simulations, we show the formation of stable triplet structure when particular GC-rich DNA duplexes are extended in solution over a timescale of hundreds of nanoseconds, in the presence of organic salt. We present planar-stacked triplet disproportionated DNA (Σ DNA) as a possible solution phase of the double helix under tension, subject to sequence and the presence of stabilising co-factors. Considering the partitioning of the duplexes into triplets of base pairs as the first step of operation of recombinase enzymes like RecA, we emphasise the structure–function relationship in Σ DNA. We supplement atomistic calculations with thermodynamic arguments to show that codons for ‘phase 1’ amino acids (those appearing early in evolution) are more likely than a lower entropy GC-rich sequence to form triplets under tension. We further observe that the four amino acids supposed (in the ‘GADV world’ hypothesis) to constitute the minimal set to produce functional globular proteins have the strongest triplet-forming propensity within the phase 1 set, showing a series of decreasing triplet propensity with evolutionary newness. The weak form of our observation provides a physical mechanism to minimise read frame and recombination alignment errors in the early evolution of the genetic code. [less ▲]

Detailed reference viewed: 11 (0 UL)
See detailSklaverei zur Zeit Diokletians und Konstantins
Binsfeld, Andrea UL

Presentation (2017, October 28)

Detailed reference viewed: 12 (1 UL)
Full Text
See detailBildung in Not!
Steffgen, Georges UL

Article for general public (2017)

Detailed reference viewed: 15 (9 UL)
See detailGuérilla UX, "quick" mais pas "dirty"
Lallemand, Carine UL

Conference given outside the academic context (2017)

Les ressources limitées des projets de conception incitent souvent à appliquer des méthodes UX rapides, low-cost, « quick & dirty ». Mais le « guerilla UX » peut aussi être « quick » sans être « dirty » ... [more ▼]

Les ressources limitées des projets de conception incitent souvent à appliquer des méthodes UX rapides, low-cost, « quick & dirty ». Mais le « guerilla UX » peut aussi être « quick » sans être « dirty », être inspirant, et constituer une alternative valide aux méthodes traditionnelles de design UX. Au-delà des célèbres tests utilisateurs à la mode Starbucks, cette conférence vous présentera de nombreuses alternatives guérilla aux entretiens, questionnaires, observations, en passant aussi par l’idéation, le storyboarding ou le maquettage. Une bonne dose d’inspiration pour se donner les moyens de faire de l’UX quand on n’en a pas les moyens ! [less ▲]

Detailed reference viewed: 22 (0 UL)
Full Text
See detailDeformation Based Curved Shape Representation
Demisse, Girum UL

Doctoral thesis (2017)

Representation and modelling of an objects' shape is critical in object recognition, synthesis, tracking and many other applications in computer vision. As a result, there is a wide range of approaches in ... [more ▼]

Representation and modelling of an objects' shape is critical in object recognition, synthesis, tracking and many other applications in computer vision. As a result, there is a wide range of approaches in formulating representation space and quantifying the notion of similarity between shapes. A similarity metric between shapes is a basic building block in modelling shape categories, optimizing shape valued functionals, and designing a classifier. Consequently, any subsequent shape based computation is fundamentally dependent on the computational efficiency, robustness, and invariance to shape preserving transformations of the defined similarity metric. In this thesis, we propose a novel finite dimensional shape representation framework that leads to a computationally efficient, closed form solution, and noise tolerant similarity distance function. Several important characteristics of the proposed curved shape representation approach are discussed in relation to earlier works. Subsequently, two different solutions are proposed for optimal parameter estimation of curved shapes. Hence, providing two possible solutions for the point correspondence estimation problem between two curved shapes. Later in the thesis, we show that several statistical models can readily be adapted to the proposed shape representation framework for object category modelling. The thesis finalizes by exploring potential applications of the proposed curved shape representation in 3D facial surface and facial expression representation and modelling. [less ▲]

Detailed reference viewed: 25 (16 UL)
Full Text
Peer Reviewed
See detailFirst draft genome sequence of a strain belonging to the Zoogloea genus and its gene expression in situ
Muller, Emilie UL; Narayanasamy, Shaman UL; Zeimes, Myriam et al

in Standards in Genomic Sciences (2017), 12(64),

The Gram-negative beta-proteobacterium Zoogloea sp. LCSB751 (LMG 29444) was newly isolated from foaming activated sludge of a municipal wastewater treatment plant. Here, we describe its draft genome ... [more ▼]

The Gram-negative beta-proteobacterium Zoogloea sp. LCSB751 (LMG 29444) was newly isolated from foaming activated sludge of a municipal wastewater treatment plant. Here, we describe its draft genome sequence and annotation together with a general physiological and genomic analysis, as the first sequenced representative of the Zoogloea genus. Moreover, Zoogloea sp. gene expression in its environment is described using metatranscriptomic data obtained from the same treatment plant. The presented genomic and transcriptomic information demonstrate a pronounced capacity of this genus to synthesize poly-β-hydroxyalkanoate within wastewater. [less ▲]

Detailed reference viewed: 23 (1 UL)