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See detailFirst World War and the Perception of Narrative Time
Kohns, Oliver UL

Scientific Conference (2017, April)

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See detailRegulated in development and DNA damage responses 1 (REDD1) links stress with IL-1β-mediated familial Mediterranean fever attack through autophagy-driven neutrophil extracellular traps
Skendros, P.; Chrysanthopoulou, A.; Rousset, F. et al

in Journal of Allergy and Clinical Immunology (2017)

Background: Familial Mediterranean fever (FMF) is an IL-1β-dependent autoinflammatory disease caused by mutations of Mediterranean fever (MEFV) encoding pyrin and characterized by inflammatory attacks ... [more ▼]

Background: Familial Mediterranean fever (FMF) is an IL-1β-dependent autoinflammatory disease caused by mutations of Mediterranean fever (MEFV) encoding pyrin and characterized by inflammatory attacks induced by physical or psychological stress. Objective: We investigated the underlying mechanism that links stress-induced inflammatory attacks with neutrophil activation and release of IL-1β-bearing neutrophil extracellular traps (NETs) in patients with FMF. Methods: RNA sequencing was performed in peripheral neutrophils from 3 patients with FMF isolated both during attacks and remission, 8 patients in remission, and 8 healthy subjects. NET formation and proteins were analyzed by using confocal immunofluorescence microscopy, immunoblotting, myeloperoxidase-DNA complex ELISA, and flow cytometry. Samples from patients with Still's disease and bacterial infections were used also. Results: The stress-related protein regulated in development and DNA damage responses 1 (REDD1) is significantly overexpressed during FMF attacks. Neutrophils from patients with FMF during remission are resistant to autophagy-mediated NET release, which can be overcome through REDD1 induction. Stress-related mediators (eg, epinephrine) decrease this threshold, leading to autophagy-driven NET release, whereas the synchronous inflammatory environment of FMF attack leads to intracellular production of IL-1β and its release through NETs. REDD1 in autolysosomes colocalizes with pyrin and nucleotide-binding domain, leucine-rich repeat/pyrin domain-containing 3. Mutated pyrin prohibits this colocalization, leading to higher IL-1β levels on NETs. Conclusions: This study provides a link between stress and initiation of inflammatory attacks in patients with FMF. REDD1 emerges as a regulator of neutrophil function upstream to pyrin, is involved in NET release and regulation of IL-1β, and might constitute an important piece in the IL-1β-mediated inflammation puzzle. © 2017 American Academy of Allergy, Asthma & Immunology. [less ▲]

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See detailA foam model highlights the differences of the macro- and microrheology of respiratory horse mucus
Wagner, Christian UL; Gross, Andreas; Schaefer, Ulrich F. et al

in Journal of the Mechanical Behavior of Biomedical Materials (2017)

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See detailUnravelling a p73-regulated network: The role of a novel p73-dependent target, MIR3158, in cancer cell migration and invasiveness
Galtsidis, Sotirios UL; Logotheti, S.; Pavlopoulou, A. et al

in Cancer Letters (2017), 388

The transcription factor p73 is homologous to the well-known tumor-suppressor p53. The p73-regulated networks are of significant clinical interest, because they may substitute for impaired p53-regulated ... [more ▼]

The transcription factor p73 is homologous to the well-known tumor-suppressor p53. The p73-regulated networks are of significant clinical interest, because they may substitute for impaired p53-regulated networks which are commonly perturbed in cancer. Herein, we aimed to characterize a p73-regulated network that mediates cell migration and restores anti-oncogenic responses in p53-mutant cancer cells. In this study, we demonstrate that p73 regulates a network underlying cell migration, which consists of MIR34A/MIR3158/vimentin/β-catenin/lef1. The p73 isoforms transactivate the miRNA components (MIR34A/MIR3158) of this network, which in turn, downregulate their EMT-related mRNA co-targets (vimentin/β-catenin/lef1) to decrease cell-migration. Modulation of this network, by increasing the level of the novel p73-dependent target MIR3158, was found to induce anti-oncogenic/anti-invasive responses in p53-mutant cancer cells. Taken together, a p73-regulated, MIR3158-containing, network restores anti-invasive phenotypes in p53-mutant cancer cells; this property could be exploited towards the development of anticancer therapeutics. © 2016 Elsevier Ireland Ltd [less ▲]

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See detailA Multi-Pronged Approach to Adaptive and Context Aware Content Dissemination in VANETs
Duarte, Joao; Kalogeiton, Eirini; Soua, Ridha UL et al

in Mobile Networks and Applications (2017)

Content dissemination in Vehicular Ad-hoc Networks (VANETs) has the potential to enable a myriad of applications, ranging from advertising, traffic and emergency warnings to infotainment. This variety in ... [more ▼]

Content dissemination in Vehicular Ad-hoc Networks (VANETs) has the potential to enable a myriad of applications, ranging from advertising, traffic and emergency warnings to infotainment. This variety in applications and services calls for mechanisms able to optimize content storing, retrieval and forwarding among vehicles, without jeopardizing network resources. Content Centric Networking (CCN), takes advantage of inherent content redundancy in the network in order to decrease the utilization of network resources, improve response time and content availability, coping efficiently with some of the effects of mobility. Floating Content (FC), on the other hand, holds potential to implement efficiently a large amount of vehicular applications thanks to its property of geographic content replication, while Software Defined Networking (SDN), is an attractive solution for the lack of flexibility and dynamic programmability that characterizes current VANET architectures. By implementing a logical centralization of the network, SDN enables dynamic and efficient management of network resources. In this paper, for a few reference scenarios, we illustrate how approaches that combine CCN, FC and SDN enable an innovative adaptive VANET architecture able to efficiently accommodate to intermittent connectivity, fluctuating node density and mobility patterns on one side and application performance and network resources on the other side, aiming to achieve high QoS. For each scenario, we highlight the main open research challenges, and we describe possible solutions to improve content dissemination and reduce replication without affecting content availability. [less ▲]

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See detailA Model for the Transient Subdiffusive Behavior of Particles in Mucus
Ernst, Matthias; John, Thomas; Guenther, Marco et al

in Biophysical Journal (2017)

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See detailThe RIGHT model for Continuous Experimentation
Fagerholm, Fabian; Sanchez Guinea, Alejandro UL; Mäenpää, Hanna et al

in Journal of Systems and Software (2017), 123

Context: Development of software-intensive products and services increasingly occurs by continuously deploying product or service increments, such as new features and enhancements, to customers. Product ... [more ▼]

Context: Development of software-intensive products and services increasingly occurs by continuously deploying product or service increments, such as new features and enhancements, to customers. Product and service developers must continuously find out what customers want by direct customer feedback and usage behaviour observation. Objective: This paper examines the preconditions for setting up an experimentation system for continuous customer experiments. It describes the RIGHT model for Continuous Experimentation (Rapid Iterative value creation Gained through High-frequency Testing), illustrating the building blocks required for such a system. Method: An initial model for continuous experimentation is analytically derived from prior work. The model is matched against empirical case study findings from two startup companies and further developed. Results: Building blocks for a continuous experimentation system and infrastructure are presented. Conclusions: A suitable experimentation system requires at least the ability to release minimum viable products or features with suitable instrumentation, design and manage experiment plans, link experiment results with a product roadmap, and manage a flexible business strategy. The main challenges are proper, rapid design of experiments, advanced instrumentation of software to collect, analyse, and store relevant data, and the integration of experiment results in both the product development cycle and the software development process. [less ▲]

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See detailKomparatistische Ansätze für eine interkulturelle Literaturgeschichte Luxemburgs
Glesener, Jeanne UL

in Glesener, Jeanne; Roelens, Nathalie; Sieburg, Heinz (Eds.) Das Paradigma der Interkulturalität. Themen und Positionen in europäischen Literaturwissenschaften. (2017)

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See detailIdentifying the Real Minority Carrier Lifetime in Nonideal Semiconductors: A Case Study of Kesterite Materials
Hages, Charles J.; Redinger, Alex UL; Levcenko, Sergiu et al

in Advanced Energy Materials (2017)

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See detailGrab / Grabinschriften
Binsfeld, Andrea UL

in Heinen, Heinz (Ed.) Handwörterbuch der antiken Sklaverei (2017)

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See detailL’argomento dell’effet utile nell’espansione del diritto del lavoro europeo
Ratti, Luca UL

in Giornale di Diritto del Lavoro e di Relazioni Industriali (2017)

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See detailL’invalidità (quasi) satisfattiva nel diritto del lavoro
Ratti, Luca UL

in Lavoro e diritto (2017)

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See detailHochbegabte Schüler/innen: Was Lehrkräfte glauben, wie sie sind.
Baudson, Tanja UL

in Praxis Schulpsychologie (2017), 10

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See detailNullità di protezione e contratto di lavoro: una convergenza apparente
Ratti, Luca UL

in Variazioni su temi diritto del lavoro (2017), 4

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See detailLe clausole sociali di seconda generazione: inventario di questioni
Ratti, Luca UL

in Rivista Giuridica del Lavoro e della Previdenza Sociale (2017)

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See detailFunctional inequalities on manifolds with non-convex boundary
Cheng, Li Juan UL; Thalmaier, Anton UL; Thompson, James UL

E-print/Working paper (2017)

In this article, new curvature conditions are introduced to establish functional inequalities including gradient estimates, Harnack inequalities and transportation-cost inequalities on manifolds with non ... [more ▼]

In this article, new curvature conditions are introduced to establish functional inequalities including gradient estimates, Harnack inequalities and transportation-cost inequalities on manifolds with non-convex boundary. [less ▲]

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See detailArchäologie
Binsfeld, Andrea UL

in Heinen, Heinz (Ed.) Handwörterbuch der antiken Sklaverei (2017)

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See detailSchulbuch
Binsfeld, Andrea UL

in Heinen, Heinz (Ed.) Handwörterbuch der antiken Sklaverei (2017)

Detailed reference viewed: 11 (0 UL)