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See detailChanges in Childhood and Adolescence: Current Challenges for Physical Education
Bund, Andreas UL; Scheuer, Claude

Book published by Logos-Verlag (2017)

Founded in 1923 in Brussels, the Fédération Internationale d'Éducation Physique (FIEP) is an independent and globally engaged organization, aimed at promoting a broad range of activities in the fields of ... [more ▼]

Founded in 1923 in Brussels, the Fédération Internationale d'Éducation Physique (FIEP) is an independent and globally engaged organization, aimed at promoting a broad range of activities in the fields of physical education, sport for all, fitness and health, and recreation for people of all ages. It provides a network of contacts and a means of communication and exchange amongst scientists and organizations. At the 12th FIEP European Congress in Luxembourg, leading researchers and educationalists from all over Europe addressed current challenges and developments in the field of physical education, for example, the physical activity behavior of young people, intercultural learning and inclusion and the use of digital technologies. [less ▲]

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See detailNatural Resource Management: A Network Perspective
Kyriakopoulou, Efthymia UL; Xepapadeas, Anastasios

Scientific Conference (2017, September)

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See detailComparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis
Androsova, Ganna UL; Krause, Roland UL; Borghei, Mojgansadat et al

in Epilepsia (2017)

Objective: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a common epilepsy syndrome that is often poorly controlled by antiepileptic drug (AED) treatment. Comparative AED ... [more ▼]

Objective: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a common epilepsy syndrome that is often poorly controlled by antiepileptic drug (AED) treatment. Comparative AED effectiveness studies in this condition are lacking. Wereport retention, efficacy, and tolerability in a cohort of patients with MTLE-HS. Methods: Clinical data were collected from a European database of patients with epilepsy. We estimated retention, 12-month seizure freedom, and adverse drug reaction (ADR) rates for the 10 most commonly used AEDs in patients with MTLE-HS. Results: Seven hundred sixty-seven patients with a total of 3,249 AED trials were included. The highest 12-month retention rates were observed with carbamazepine (85.9%), valproate (85%), and clobazam (79%). Twelve-month seizure freedom rates varied from 1.2% for gabapentin and vigabatrin to 11% for carbamazepine. Response rates were highest for AEDs that were prescribed as initial treatment and lowest for AEDs that were used in a third or higher instance. ADRs were reported in 47.6% of patients, with the highest rates observed with oxcarbazepine (35.7%), topiramate (30.9%), and pregabalin (27.4%), and the lowest rates with clobazam (6.5%), gabapentin (8.9%), and lamotrigine (16.6%). The most commonly reported ADRs were lethargy and drowsiness, dizziness, vertigo and ataxia, and blurred vision and diplopia. Significance: Our results did not demonstrate any clear advantage of newer versus older AEDs. Our results provide useful insights into AED retention, efficacy, and ADR rates in patients with MTLE-HS. [less ▲]

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See detailElastic properties of the nematic phase in hard ellipsoids of short aspect ratio
Heymans, Sven UL; Schilling, Tanja UL

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2017), 96(022708),

We present a Monte Carlo simulation study of suspensions of hard ellipsoids of revolution. Based on the spatial fluctuations of the orientational order, we have computed the Frank elastic constants for ... [more ▼]

We present a Monte Carlo simulation study of suspensions of hard ellipsoids of revolution. Based on the spatial fluctuations of the orientational order, we have computed the Frank elastic constants for prolate and oblate ellipsoids and compared them to the affine transformation model. The affine transformation model predicts the right order of magnitude of the twist and bend constant but not of the splay constant. In addition, we report the observation of a stable nematic phase at an aspect ratio as low as 2.5. [less ▲]

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See detailReconceptualising Global Finance and Its Regulation
Nabilou, Hossein UL

in Banking & Finance Law Review (2017), 32(3), 579-602

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See detailQuantitative systems pharmacology and the personalized drug–microbiota–diet axis
Thiele, Ines UL; Clancy, Catherine UL; Heinken, Almut Katrin UL et al

in Current Opinion in Systems Biology (2017), 4

Precision medicine is an emerging paradigm that aims at maximizing the benefits and minimizing the adverse effects of drugs. Realistic mechanistic models are needed to understand and limit heterogeneity ... [more ▼]

Precision medicine is an emerging paradigm that aims at maximizing the benefits and minimizing the adverse effects of drugs. Realistic mechanistic models are needed to understand and limit heterogeneity in drug responses. While pharmacokinetic models describe in detail a drug's absorption and metabolism, they generally do not account for individual variations in response to environmental influences, in addition to genetic variation. For instance, the human gut microbiota metabolizes drugs and is modulated by diet, and it exhibits significant variation among individuals. However, the influence of the gut microbiota on drug failure or drug side effects is under-researched. Here, we review recent advances in computational modeling approaches that could contribute to a better, mechanism-based understanding of drug–microbiota–diet interactions and their contribution to individual drug responses. By integrating systems biology and quantitative systems pharmacology with microbiology and nutrition, the conceptually and technologically demand for novel approaches could be met to enable the study of individual variability, thereby providing breakthrough support for progress in precision medicine. [less ▲]

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See detailIndoor localization using ambient FM radio RSS fingerprinting: A 9-month study
Popleteev, Andrei UL

in 17th IEEE International Conference on Computer and Information Technology (CIT-2017) (2017, August)

While indoor positioning systems aspire for higher accuracy, their coverage is typically limited to buildings with dedicated hardware. A possible alternative is offered by infrastructure-free positioning ... [more ▼]

While indoor positioning systems aspire for higher accuracy, their coverage is typically limited to buildings with dedicated hardware. A possible alternative is offered by infrastructure-free positioning methods. In particular, several studies have demonstrated feasibility of indoor positioning using broadcast FM radio signals, which are available in most populated areas worldwide. However, previous work provides little information about long-term performance of FM-based indoor localization. This paper presents a longitudinal study of FM indoor positioning based on received signal strength (RSS) fingerprinting. We evaluate system's performance on a large dataset of real-world FM signals, systematically collected in several large-scale multi-floor testbeds over the course of 9 months. We also investigate the impact of different classifiers, training schedules and fingerprint sizes on localization accuracy. The results demonstrate that well-trained FM-based system can provide reliable indoor positioning even several months after deployment. [less ▲]

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See detailAgile Validation of Model Transformations using Compound F-Alloy Specifications
Gammaitoni, Loïc UL; Kelsen, Pierre UL; Ma, Qin

in Science of Computer Programming (2017)

Model transformations play a key role in model driven software engineering approaches. Validation of model transformations is crucial for the quality assurance of software systems to be constructed. The ... [more ▼]

Model transformations play a key role in model driven software engineering approaches. Validation of model transformations is crucial for the quality assurance of software systems to be constructed. The relational logic based specification language Alloy and its accompanying tool the Alloy Analyzer have been used in the past to validate properties of model transformations. However Alloy based analysis of transformations suffers from several limitations. On one hand, it is time consuming and does not scale well. On the other hand, the reliance on Alloy, being a formal method, prevents the effective involvement of domain experts in the validation process which is crucial for pinpointing domain pertinent errors. Those limitations are even more severe when it comes to transformations whose input and/or output are themselves transformations (called compound transformations) because they are inherently more complex. To tackle the performance and scalability limitations, in previous work, we proposed an Alloy-based Domain Specific Language (DSL), called F-Alloy, that is tailored for model transformation specifications. Instead of pure analysis based validation, F-Alloy speeds up the validation of model transformations by applying a hybrid strategy that combines analysis with interpretation. In this paper, we formalize the notion of “hybrid analysis” and further extended it to also support efficient validation of compound transformations. To enable the effective involvement of domain experts in the validation process, we propose in this paper a new approach to model transformation validation, called Visualization-Based Validation (briefly VBV). Following VBV, representative instances of a to-be-validated model transformation are automatically generated by hybrid analysis and shown to domain experts for feedback in a visual notation that they are familiar with. We prescribe a process to guide the application of VBV to model transformations and illustrate it with a benchmark model transformation. [less ▲]

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See detailRemarks on Contact and Jacobi Geometry
Bruce, Andrew UL; Grabowska, Katarzyna; Grabowski, Janusz

in Symmetry, Integrability and Geometry: Methods and Applications [=SIGMA] (2017), 13(059), 22

We present an approach to Jacobi and contact geometry that makes many facts, presented in the literature in an overcomplicated way, much more natural and clear. The key concepts are Kirillov manifolds and ... [more ▼]

We present an approach to Jacobi and contact geometry that makes many facts, presented in the literature in an overcomplicated way, much more natural and clear. The key concepts are Kirillov manifolds and linear Kirillov structures, i.e., homogeneous Poisson manifolds and, respectively, homogeneous linear Poisson manifolds. The difference with the existing literature is that the homogeneity of the Poisson structure is related to a principal GL(1,ℝ)-bundle structure on the manifold and not just to a vector field. This allows for working with Jacobi bundle structures on nontrivial line bundles and drastically simplifies the picture of Jacobi and contact geometry. Our results easily reduce to various basic theorems of Jacobi and contact geometry when the principal bundle structure is trivial, while giving new insights into the theory. [less ▲]

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See detailObservation and Control of Anaerobic Digestion Processes for Improved Biogas Production
Chaib Draa, Khadidja UL

Doctoral thesis (2017)

In this thesis, we propose a formal modelling framework for the anaerobic digestion process, where we add more degrees of freedom in the control of biogas production. Indeed, we add two additional control ... [more ▼]

In this thesis, we propose a formal modelling framework for the anaerobic digestion process, where we add more degrees of freedom in the control of biogas production. Indeed, we add two additional control inputs to the standardized AM2 (Acidogenesis Methanogenesis, 2 steps) model, re ecting addition of stimulating substrates which enhance the biogas quality and quantity. Then, we describe how the parameters of the resulted nonlinear model can be identi ed, and we analyse the positiveness and boundedness of its state variables. Based on the derived mathematical model and the analysis results, we design di erent software sensors to overcome the lack of reliable and cheap sensors. Indeed, we present a general class of systems to which the considered process model belongs. Then, we design an LMI-based invariant like observer as well as an LMI-based nonlinear observer of the same form as the generalized Arcak's observer. Furthermore, with the aim to render the observer design more robust to disturbances, we include the H1 criterion in its synthesis. Also, to promote the use of the proposed observers in real applications, we extend the methodology to the discrete time case and to the case of nonlinear systems with nonlinear outputs. For the di erent observers design, we use the di erential mean value theorem which allows the transformation of the nonlinear estimation error to a linear parameter varying system. Then, we use the Lipschitz conditions and the Lyapunov standard function to synthesize the stability conditions in the form of linear matrix inequalities. Finally, we enhance the feasibility of the later conditions by using a judicious reformulation of the Young's inequality. In the thesis, we also deal with the process control where we propose a control strategy to track an admissible reference trajectory planned by the plant operator. Moreover, to account for the partial availability of the state vector measurements, we include an exponential nonlinear observer in the control synthesis. Thus, we design an observer based tracking control scheme. To perform the stability analysis of the closed loop system, composed of the system, the observer and the controller, we use the Barbalat's lemma conjointly with the techniques already mentioned for the observers design. Finally, we propose two different methods to compute the controller and the observer parameters. In the first one, we propose to compute them separately. While, in the second one we compute the parameters simultaneously. [less ▲]

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See detailAtmospheric pollution in rapidly growing industrial cities: spatial policies and land use patterns
Kyriakopoulou, Efthymia UL; Xepapadeas, Anastasios

in Journal of Economic Geography (2017)

We study the optimal and equilibrium distribution of industrial and residential land in a given region. The trade-off between agglomeration and dispersion forces in the form of pollution from stationary ... [more ▼]

We study the optimal and equilibrium distribution of industrial and residential land in a given region. The trade-off between agglomeration and dispersion forces in the form of pollution from stationary forces, production externalities and commuting costs, determines the emergence of industrial and residential clusters across space. In this context, we define two kinds of spatial policies that can be used in order to close the gap between optimal and market allocations. More specifically, we show that the joint implementation of a site-specific environmental tax and a site-specific labor subsidy can reproduce the optimum as an equilibrium outcome. The methodological approach followed in this article allows for an endogenous determination of land use patterns. [less ▲]

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See detailOperational Excellence Survey
Oberhausen, Christof UL

Speeches/Talks (2017)

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See detailInternationalisierung des Wohnens in Luxemburg – Vom empirischen Fall zum Modell
Becker, Tom UL; Christmann, Nathalie UL

Presentation (2017, June 15)

Aufgrund der sozioökonomischen und räumlichen Entwicklung des Großherzogtums ist der luxemburgische Wohnungsmarkt seit mehr als zwei Jahrzehnten vor allem durch ausgeprägte und dauerhafte Knappheiten und ... [more ▼]

Aufgrund der sozioökonomischen und räumlichen Entwicklung des Großherzogtums ist der luxemburgische Wohnungsmarkt seit mehr als zwei Jahrzehnten vor allem durch ausgeprägte und dauerhafte Knappheiten und hohe Kauf- und Mietpreise gekennzeichnet. Etliche Städte und Metropolregionen in Europa zeigen ähnliche Tendenzen auf. Spezifisch für unseren Fall sind jedoch erstens die geringe Größe des Landes sowie zweitens die fortwährenden wirtschaftlichen und demografischen Dynamiken, sie sich zum Teil in sehr starken grenzüberschreitenden, internationalen und sogar globalen Verflechtungen ausdrücken. Die Relevanz der „Internationalisierung“ des Wohnens in (und um) Luxemburg in all ihren Facetten ist allerdings nicht nur aus politischer und soziokultureller Sicht gegeben. Wegen seiner Besonderheit war der Fall in der Vergangenheit auch immer wieder Gegenstand wissenschaftlicher Untersuchungen. Bis auf einige wenige Ausnahmen waren diese Studien meist quantitativ angelegt und beschränkten sich vor allem auf die durch die sozioökonomischen Entwicklungen verursachten räumlichen Effekte der Internationalisierung des Wohnens. So wurden zwischen seit Mitte der 2000er Jahre z.B. mehrere Studien über Grenzpendlerströme und deren Auswirkungen auf das Wirtschaftswachstum, die Mobilität und das Wohnen in Luxemburg durchgeführt. Auch das Ausmaß und die Beweggründe für den Abzug von im Großherzogtum lebenden luxemburgischen und ausländischen Bürgern in das grenznahe Ausland wurde im Detail erforscht. Der luxemburgische Immobilienmarkt ist durch eine sehr dynamische Entwicklung und einen hohen Grad an Internationalität gekennzeichnet ist. Unser Beitrag zielt hauptsächlich darauf ab, die bisher vorherrschende wissenschaftliche Debatte über die Frage der Internationalisierung des Luxemburger Wohnungsmarktes erneut zu öffnen und sie um den Aspekt der Governance zu erweitern. Auf diese Weise sollen einerseits der Begriff der „Internationalisierung“ mit seinen z.T. sehr unterschiedlichen Wirkungsweisen im Bereich des Wohnens in Luxemburg differenzierter ergründet und andererseits neue Forschungsansätze entwickelt werden. Unsere Aussagen beruhen im Wesentlichen auf der Auswertung von Dokumenten und Sekundärmaterial zum Thema sowie der aktiven Mitwirkung an relevanten Fachdiskussionen zum Thema Wohnen in Luxemburg. [less ▲]

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See detailComparative evaluation of atom mapping algorithms for balanced metabolic reactions: application to Recon 3D
Preciat Gonzalez, German Andres UL; El Assal, Lemmer UL; Noronha, Alberto UL et al

in Journal of Cheminformatics (2017)

The mechanism of each chemical reaction in a metabolic network can be represented as a set of atom mappings, each of which relates an atom in a substrate metabolite to an atom of the same element in a ... [more ▼]

The mechanism of each chemical reaction in a metabolic network can be represented as a set of atom mappings, each of which relates an atom in a substrate metabolite to an atom of the same element in a product metabolite. Genome-scale metabolic network reconstructions typically represent biochemistry at the level of reaction stoichiometry. However, a more detailed representation at the underlying level of atom mappings opens the possibility for a broader range of biological, biomedical and biotechnological applications than with stoichiometry alone. Complete manual acquisition of atom mapping data for a genome-scale metabolic network is a laborious process. However, many algorithms exist to predict atom mappings. How do their predictions compare to each other and to manually curated atom mappings? For more than four thousand metabolic reactions in the latest human metabolic reconstruction, Recon 3D, we compared the atom mappings predicted by six atom mapping algorithms. We also compared these predictions to those obtained by manual curation of atom mappings for over five hundred reactions distributed among all top level Enzyme Commission number classes. Five of the evaluated algorithms had similarly high prediction accuracy of over 91% when compared to manually curated atom mapped reactions. On average, the accuracy of the prediction was highest for reactions catalysed by oxidoreductases and lowest for reactions catalysed by ligases. In addition to prediction accuracy, the algorithms were evaluated on their accessibility, their advanced features, such as the ability to identify equivalent atoms, and their ability to map hydrogen atoms. In addition to prediction accuracy, we found that software accessibility and advanced features were fundamental to the selection of an atom mapping algorithm in practice. [less ▲]

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See detailPoster: Impact of ground truth errors on Wi-Fi localization accuracy
Popleteev, Andrei UL

Poster (2017, June)

This study investigates the impact of small ground truth (GT) errors on indoor positioning systems based on Wi-Fi fingerprinting. The results demonstrate that even centimeter-scale GT deviations cause ... [more ▼]

This study investigates the impact of small ground truth (GT) errors on indoor positioning systems based on Wi-Fi fingerprinting. The results demonstrate that even centimeter-scale GT deviations cause severe degradation of measured localization accuracy. [less ▲]

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See detailArbeiten unter Hitler. NS-Sozialpolitik und Herrschaftspraxis im besetzten Luxemburg 1940-1944
Schoentgen, Marc Mike Claude UL

Doctoral thesis (2017)

Die Arbeit untersucht Grundlagen, Konzeptionen und Auswirkungen der nationalsozialistischen Besatzungsherrschaft in Luxemburg (1940-1944) in den Bereichen der Wirtschafts- und Sozialpolitik ... [more ▼]

Die Arbeit untersucht Grundlagen, Konzeptionen und Auswirkungen der nationalsozialistischen Besatzungsherrschaft in Luxemburg (1940-1944) in den Bereichen der Wirtschafts- und Sozialpolitik. Berücksichtigung findet auch die NS-Volkstums- und Kulturpolitik. Staatliche Maßnahmen führten in der Besatzungszeit dazu, dass während einer relativ langen Phase die Auswirkungen des Krieges auf das Alltags- und Arbeitsleben wenig spürbar waren. Damit trug die Sozialpolitik zu einer politischen und psychologischen Stabilisierung des Regimes bei. Besonders betroffen von der Politik des nationalsozialistischen Gauleiters Gustav Simon waren die Luxemburger Gewerkschaften, die von den Machthabern instrumentalisiert und anschließend liquidiert wurden. An ihre Stelle trat die Deutsche Arbeitsfront, größte Massenorganisation des Regimes, die ihre vielfältigen Aktivitäten in den Bereichen der Sozial-, Wirtschafts-, Freizeit- und Kulturpolitik auch auf Luxemburg ausdehnte. Genauer untersucht wird die Institution des Stillhaltekommissars für das Organisationswesen, der die Gewerkschaften und andere Vereine liquidierte beziehungsweise nazifizierte. Damit wurden die Fundamente der Luxemburger Gesellschaft in Frage gestellt. Die Neuordnungspolitik des Regimes wird u.a. am Beispiel des Industriegebiets im Süden Luxemburgs dargestellt. Im Arbeitermilieu sahen die nationalsozialistischen Machthaber ein Experimentierfeld ihrer Politik. Krieg und Besatzung hatten letztlich auch Auswirkungen auf die großen Industriebetriebe. Gerade hier änderte sich ab der zweiten Hälfte des Krieges durch unterschiedliche Formen der Repression und Zwangsarbeit der Alltag der Menschen. Übergreifend befasst sich die Arbeit auch mit der Luxemburger Kriegsgesellschaft beziehungsweise den unterschiedlichen Reaktionen der Arbeiter und Angestellten auf Verlockung und Zwang. Kapitel: 1. Die NS-Sozialpolitik in Luxemburg 2. Die Luxemburger Gewerkschaften im Krieg. 3. Das Luxemburger Industriegebiet 4. Der Stillhaltekommissar für das Organisationswesen 5. Die Deutsche Arbeitsfront 6. Arbeiten im Krieg [less ▲]

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