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See detailAffaire Berlioz : Enseignements de la CJUE et recommandations à l’attention du législateur
Chaouche, Fatima UL; Sinnig, Julia UL

in Revue Générale de Fiscalité Luxembourgeoise (in press)

Après avoir introduit un recours préjudiciel devant la Cour de Justice de l’Union Européenne (ci-après « CJUE ») quant à la compatibilité des dispositions luxembourgeoises en matière d’échange de ... [more ▼]

Après avoir introduit un recours préjudiciel devant la Cour de Justice de l’Union Européenne (ci-après « CJUE ») quant à la compatibilité des dispositions luxembourgeoises en matière d’échange de renseignements avec le droit de l’Union, la Cour administrative a statué dans la désormais célèbre affaire Berlioz dans son arrêt du 26 octobre 2017. Sans grande surprise, la Cour administrative a invalidé la décision directoriale enjoignant Berlioz de se conformer à la demande d’échange française en raison de l’absence de contrôle de la pertinence vraisemblable des informations demandées. Il incombe désormais au législateur luxembourgeois de proposer un texte cohérent et conforme au droit supranational. [less ▲]

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See detailCross-border cooperation as practice formation. Perspectives for an alternative research approach
Wille, Christian UL; Connor, Ulla UL

in Beck, Joachim; Wassenberg, Birte (Eds.) Interdisciplinary discourses on cross-border cooperation in Europe (in press)

In order to achieve our objective, we will first provide an overview of the development of cooperation research, its characterizing orientations and establish a link to the topic of this contribution ... [more ▼]

In order to achieve our objective, we will first provide an overview of the development of cooperation research, its characterizing orientations and establish a link to the topic of this contribution (chapter 2). The following presentation of practice theories introduces praxeological thinking and provides a condensed outline of the state of the art of this cultural sociological theory (chapter 3). Building on this, we will develop our idea of a cross-border practice formation that breaks with the premises of traditional cooperation research, and we provide an alternative perspectivation by outlining four challenges of CBC (chapter 4). In consideration of some research-practical particularities which are linked to the suggested analytical perspective, we eventually offer (chapter 5) an outlook on the development of an alternative research approach which is compatible within a multidisciplinary context. [less ▲]

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See detailHow does food taste in anorexia and bulimia nervosa? A protocol for a quasiexperimental, cross-sectional design to investigate taste aversion or increased hedonic valence of food in eating disorders
Garcia-Burgos, David; Maglieri, Sabine; Vögele, Claus UL et al

in Frontiers in Psychology (in press)

Background. Despite on-going efforts to better understand dysregulated eating, the olfactory-gustatory deficits and food preferences in eating disorders (ED), and the mechanisms underlying the perception ... [more ▼]

Background. Despite on-going efforts to better understand dysregulated eating, the olfactory-gustatory deficits and food preferences in eating disorders (ED), and the mechanisms underlying the perception of and responses to food properties in anorexia nervosa (AN) and bulimia nervosa (BN) remain largely unknown; both during the course of the illness and compared to healthy populations. It is, therefore, necessary to systematically investigate the gustatory perception and hedonics of taste in patients with AN and BN. To this end, we will examine whether aversions to the taste of high-calorie food is related to the suppression of energy intake in restricting-type AN, and whether an increased hedonic valence of sweet, caloric-dense foods may be part of the mechanisms triggering binge-eating episodes in BN. In addition, the role of cognitions influencing these mechanisms will be examined. Method. In study 1, four mixtures of sweet-fat stimuli will be presented in a sensory two-alternative forced-choice test involving signal detection analysis. In study 2, a full-scale taste reactivity test will be carried out, including psychophysiological and behavioural measures to assess subtle and covert hedonic changes. We will compare the responses of currently-ill AN and BN patients to those who have recovered from AN and BN, and also to those of healthy normal-weight and underweight individuals without any eating disorder pathology. Discussion. If taste response profiles are differentially linked to ED types, then future studies should investigate whether taste responsiveness represents a useful diagnostic measure in the prevention, assessment and treatment of EDs. The expected results on cognitive mechanisms in the top-down processes of food hedonics will complement current models and contribute to the refinement of interventions to change cognitive aspects of food aversions, to establish functional food preferences and to better manage food cravings associated with binge-eating episodes. No trial registration was required for this protocol, which was approved by the Swiss ethics committee (CER-VD, nº2016-02150) and the Ethics Review Panel of the University of Luxembourg. [less ▲]

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See detailExperimental design trade-offs for gene regulatory network inference: an in silico study of the yeast Saccharomyces cerevisiae cell cycle
Markdahl, Johan UL; Colombo, Nicolo UL; Thunberg, Johan UL et al

in Proceedings of the 56th IEEE Conference on Decision and Control (in press)

Time-series of high throughput gene sequencing data intended for gene regulatory network (GRN) inference are often short due to the high costs of sampling cell systems. Moreover, experimentalists lack a ... [more ▼]

Time-series of high throughput gene sequencing data intended for gene regulatory network (GRN) inference are often short due to the high costs of sampling cell systems. Moreover, experimentalists lack a set of quantitative guidelines that prescribe the minimal number of samples required to infer a reliable GRN model. We study the temporal resolution of data vs.quality of GRN inference in order to ultimately overcome this deficit. The evolution of a Markovian jump process model for the Ras/cAMP/PKA pathway of proteins and metabolites in the G1 phase of the Saccharomyces cerevisiae cell cycle is sampled at a number of different rates. For each time-series we infer a linear regression model of the GRN using the LASSO method. The inferred network topology is evaluated in terms of the area under the precision-recall curve (AUPR). By plotting the AUPR against the number of samples, we show that the trade-off has a, roughly speaking, sigmoid shape. An optimal number of samples corresponds to values on the ridge of the sigmoid. [less ▲]

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See detailGesellschaftskritische Orientierungen linker Aktivisten – Ergebnisse einer qualitativen Studie.
Kühnel, Wolfgang; Willems, Helmut UL

in Behrmann, Günter C.; Schürmann, Eberhard; Willems, Helmut (Eds.) Der Felsengärtner. Freundesgabe für Roland Eckert. (in press)

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See detailSmart Bound Selection for the Verification of UML/OCL Class Diagrams
Clarisó, Robert; Gonzalez Perez, Carlos Alberto UL; Cabot, Jordi

in IEEE Transactions on Software Engineering (in press)

Correctness of UML class diagrams annotated with OCL constraints can be checked using bounded verification techniques, e.g., SAT or constraint programming (CP) solvers. Bounded verification detects faults ... [more ▼]

Correctness of UML class diagrams annotated with OCL constraints can be checked using bounded verification techniques, e.g., SAT or constraint programming (CP) solvers. Bounded verification detects faults efficiently but, on the other hand, the absence of faults does not guarantee a correct behavior outside the bounded domain. Hence, choosing suitable bounds is a non-trivial process as there is a trade-off between the verification time (faster for smaller domains) and the confidence in the result (better for larger domains). Unfortunately, bounded verification tools provide little support in the bound selection process. In this paper, we present a technique that can be used to (i) automatically infer verification bounds whenever possible, (ii) tighten a set of bounds proposed by the user and (iii) guide the user in the bound selection process. This approach may increase the usability of UML/OCL bounded verification tools and improve the efficiency of the verification process. [less ▲]

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See detailUnfairness at Work: Well-Being and Quits
D'Ambrosio, Conchita UL; Clark, Andrew; Barazzetta, Marta

in Labour Economics (in press)

We here consider the effect of the level of income that individuals consider to be fair for the job they do, which we take as measure of comparison income, on both subjective well-being and objective ... [more ▼]

We here consider the effect of the level of income that individuals consider to be fair for the job they do, which we take as measure of comparison income, on both subjective well-being and objective future job quitting. In six waves of German Socio-Economic Panel data, the extent to which own labour income is perceived to be unfair is significantly negatively correlated with subjective well-being, both in terms of cognitive evaluations (life and job satisfaction) and affect (the frequency of feeling happy, sad and angry). Perceived unfairness also translates into objective labour-market behaviour, with current unfair income predicting future job quits. [less ▲]

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See detailDer Felsengärtner. Freundesgabe für Roland Eckert.
Behrmann, Günter C.; Schürmann, Eberhard; Willems, Helmut UL

Book published by Spurbuch Verlag (in press)

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See detailSchulische und außerschulische Jugendbildung. Konzepte, Zielsetzung, pädagogische Ansätze.
Würtz, Stefanie; Willems, Helmut UL

in Behrmann, Günter C.; Schürmann, Eberhard; Willems, Helmut (Eds.) Der Felsengärtner. Freundesgabe für Roland Eckert. (in press)

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See detailUne cour constitutionnelle différente des autres. Etendue, raisons & avenir de l'originalité de la Cour constitutionnelle luxembourgeoise
Heuschling, Luc UL

in Gerkrath, Jörg (Ed.) Les 20 ans de la Cour Constitutionnelle: trop jeune pour mourir? (in press)

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See detailA structure-activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins
Nyffeler, Johanna; Chovancova, Petra; Dolde, Xenia et al

in Archives of Toxicology (in press)

Migration of neural crest cells (NCC) is a fundamental developmental process, and test methods to identify interfering toxicants have been developed. By examining cell function endpoints, as in the ... [more ▼]

Migration of neural crest cells (NCC) is a fundamental developmental process, and test methods to identify interfering toxicants have been developed. By examining cell function endpoints, as in the ‘migration-inhibition of NCC (cMINC)’ assay, a large number of toxicity mechanisms and protein targets can be covered. However, the key events that lead to the adverse effects of a given chemical or group of related compounds are hard to elucidate. To address this issue, we explored here, whether the establishment of two overlapping structure–activity relationships (SAR)—linking chemical structure on the one hand to a phenotypic test outcome, and on the other hand to a mechanistic endpoint—was useful as strategy to identify relevant toxicity mechanisms. For this purpose, we chose polychlorinated biphenyls (PCB) as a large group of related, but still toxicologically and physicochemically diverse structures. We obtained concentration-dependent data for 26 PCBs in the cMINC assay. Moreover, the test chemicals were evaluated by a new high-content imaging method for their effect on cellular re-distribution of connexin43 and for their capacity to inhibit gap junctions. Non-planar PCBs inhibited NCC migration. The potency (1–10 μM) correlated with the number of ortho-chlorine substituents; non-ortho-chloro (planar) PCBs were non-toxic. The toxicity to NCC partially correlated with gap junction inhibition, while it fully correlated (p < 0.0004) with connexin43 cellular re-distribution. Thus, our double-SAR strategy revealed a mechanistic step tightly linked to NCC toxicity of PCBs. Connexin43 patterns in NCC may be explored as a new endpoint relevant to developmental toxicity screening. [less ▲]

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See detailQuasitrivial semigroups: characterizations and enumerations
Couceiro, Miguel; Devillet, Jimmy UL; Marichal, Jean-Luc UL

in Semigroup Forum (in press)

We investigate the class of quasitrivial semigroups and provide various characterizations of the subclass of quasitrivial and commutative semigroups as well as the subclass of quasitrivial and order ... [more ▼]

We investigate the class of quasitrivial semigroups and provide various characterizations of the subclass of quasitrivial and commutative semigroups as well as the subclass of quasitrivial and order-preserving semigroups. We also determine explicitly the sizes of these classes when the semigroups are defined on finite sets. As a byproduct of these enumerations, we obtain several new integer sequences. [less ▲]

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See detailThe Matthew Effect in Electoral Campaigns: Increase in Policy Congruence Inequality During the Campaign
Walgrave, Stefaan; Lesschaeve, Christophe UL

in Electoral Studies : An International Journal (in press)

Previous studies have almost consistently found differences between lower and higher educated voters regarding their policy congruence, the policy position agreement between voters and their party. This ... [more ▼]

Previous studies have almost consistently found differences between lower and higher educated voters regarding their policy congruence, the policy position agreement between voters and their party. This study analyses the role of a campaign herein. Based on novel panel evidence with an extensive battery of policy statements, combined with a survey of party leaders using the same items, we find that, more than the lowly educated, the highly educated profit from the campaign to increase their policy congruence. The reason for the increased inequality is that the later switch parties more often during the campaign than the former. Our evidence also suggests that the higher educated switch parties because this may increase their policy congruence. In sum, the campaign produces a Matthew effect. Those already having a higher policy congruence increase their congruence even further, while those with a lower congruence to start with, do not make any significant progress. [less ▲]

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See detailAn Experience Report On Applying Software Testing Academic Results In Industry: We Need Usable Automated Test Generation
Arcuri, Andrea UL

in Empirical Software Engineering (in press)

What is the impact of software engineering research on current practices in industry? In this paper, I report on my direct experience as a PhD/post-doc working in software engineering research projects ... [more ▼]

What is the impact of software engineering research on current practices in industry? In this paper, I report on my direct experience as a PhD/post-doc working in software engineering research projects, and then spending the following five years as an engineer in two different companies (the first one being the same I worked in collaboration with during my post-doc). Given a background in software engineering research, what cutting-edge techniques and tools from academia did I use in my daily work when developing and testing the systems of these companies? Regarding validation and verification (my main area of research), the answer is rather short: as far as I can tell, only FindBugs. In this paper, I report on why this was the case, and discuss all the challenging, complex open problems we face in industry and which somehow are ``neglected'' in the academic circles. In particular, I will first discuss what actual tools I could use in my daily work, such as JaCoCo and Selenium. Then, I will discuss the main open problems I faced, particularly related to environment simulators, unit and web testing. After that, popular topics in academia are presented, such as UML, regression and mutation testing. Their lack of impact on the type of projects I worked on in industry is then discussed. Finally, from this industrial experience, I provide my opinions about how this situation can be improved, in particular related to how academics are evaluated, and advocate for a greater involvement into open-source projects. [less ▲]

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See detailComputational systems biology approaches for Parkinson's disease
Glaab, Enrico UL

in Cell & Tissue Research (in press)

Parkinson’s disease (PD) is a prime example of a complex and heterogeneous disorder, characterized by multifaceted and varied motor- and non-motor symptoms and different possible interplays of genetic and ... [more ▼]

Parkinson’s disease (PD) is a prime example of a complex and heterogeneous disorder, characterized by multifaceted and varied motor- and non-motor symptoms and different possible interplays of genetic and environmental risk factors. While investigations of individual PD-causing mutations and risk factors in isolation are providing important insights to improve our understanding of the molecular mechanisms behind PD, there is a growing consensus that a more complete understanding of these mechanisms will require an integrative modeling of multifactorial disease-associated perturbations in molecular networks. Identifying and interpreting the combinatorial effects of multiple PD-associated molecular changes may pave the way towards an earlier and reliable diagnosis and more effective therapeutic interventions. This review provides an overview of computational systems biology approaches developed in recent years to study multifactorial molecular alterations in complex disorders, with a focus on PD research applications. Strengths and weaknesses of different cellular pathway and network analyses, and multivariate machine learning techniques for investigating PD-related omics data are discussed, and strategies proposed to exploit the synergies of multiple biological knowledge and data sources. A final outlook provides an overview of specific challenges and possible next steps for translating systems biology findings in PD to new omics-based diagnostic tools and targeted, drug-based therapeutic approaches. [less ▲]

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See detailEfficacy of metacognitive therapy in improving mental health: A meta-analysis of single-case studies
Rochat, Lucien; Manolov, Rumen; Billieux, Joël UL

in Journal of Clinical Psychology (in press)

Context. Metacognitive therapy and one of its treatment components, the attention training technique are increasingly being delivered to improve mental health. Objective. To examine the efficacy of ... [more ▼]

Context. Metacognitive therapy and one of its treatment components, the attention training technique are increasingly being delivered to improve mental health. Objective. To examine the efficacy of metacognitive therapy and/or attention training technique on mental health outcomes from single-case studies. Methods. Fourteen studies (53 patients) were included. The d-statistic for multiple baseline data and the percentage change index were used to compute the effect sizes. Results. Metacognitive therapy has a large effect on depression, anxiety, other psychopathological symptoms, and all outcomes together. Effect sizes were significantly moderated by the number of sessions, the severity and duration of symptoms, and patient gender, but not by study quality or attention training technique when used as a stand-alone treatment. At the follow-up, 77.36% of the individuals were considered recovered or had maintained improvement. Conclusion. Metacognitive therapy and attention training technique strongly contribute to improving mental health outcomes. This study effectively informs evidence-based practice in the clinical milieu. [less ▲]

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See detailLessons from social network analysis to Industry 4.0
Omar, Yamila UL; Minoufekr, Meysam UL; Plapper, Peter UL

in Manufacturing Letters (in press)

With the advent of Industry 4.0, a growing number of sensors within modern production lines generate high volumes of data. This data can be used to optimize the manufacturing industry in terms of complex ... [more ▼]

With the advent of Industry 4.0, a growing number of sensors within modern production lines generate high volumes of data. This data can be used to optimize the manufacturing industry in terms of complex network topology metrics commonly used in the analysis of social and communication networks. In this work, several such metrics are presented along with their appropriate interpretation in the field of manufacturing. Furthermore, the assumptions under which such metrics are defined are assessed in order to determine their suitability. Finally, their potential application to identify performance limiting resources, allocate maintenance resources and guarantee quality assurance are discussed. [less ▲]

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See detailFurther exploration of the SUPPS-P Impulsive Behavior Scale’s factor structure: Evidence from a large Hungarian sample
Zsila, Ágnes; Bőthe, Beáta; Demetrovics, Zsolt et al

in Current Psychology (in press)

Background: Impulsivity is a multidimensional construct playing a pervasive role in psychiatry and neuropsychology. Lynam et al. (2006) have developed the 59-item UPPS-P Impulsive Behavior Scale, which ... [more ▼]

Background: Impulsivity is a multidimensional construct playing a pervasive role in psychiatry and neuropsychology. Lynam et al. (2006) have developed the 59-item UPPS-P Impulsive Behavior Scale, which assesses five distinct impulsivity dimensions: positive urgency, negative urgency, lack of perseverance, lack of premeditation, and sensation seeking. The short, 20-item version of the UPPS-P (SUPPS-P; Billieux et al. 2012) has been developed and adapted into several languages, including English, French, Italian, Spanish, and Arabic. The aim of the present study was to test four theoretical models of the SUPPS-P in a large sample of Hungarian adults. Methods: A total of 15,703 participants (64.76% male; Mage = 33.42 years, SD = 11.06) completed the SUPPS-P using an online questionnaire. Results: Confirmatory factor analyses corroborated the first-order five-factor model of impulsivity and a hierarchical model representing three higher-order constructs (urgency, lack of conscientiousness, sensation seeking), whereas the one-factor and three-factor model were not supported. The factor structure of the SUPPS-P preserved the original, theory-driven structure of the UPPS-P model and this instrument demonstrated good internal consistency. Hypersexual behavior consequences were positively associated with most SUPPS-P components, thus criterion validity was also supported. Conclusion: The SUPPS-P had strong psychometric properties that reflected the theoretical structure of the original UPPS-P model, thus it constitutes a theoretically grounded and time saving multidimensional instrument for assessing impulsivity. [less ▲]

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