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See detailJeux sans Frontières? - Grenzgänge der Geschichtswissenschaft
Fickers, Andreas UL; Haude, Rüdiger; Krebs, Stefan UL et al

Book published by transcript (2017)

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See detailDNA partitions into triplets under tension in the presence of organic cations, with sequence evolutionary age predicting the stability of the triplet phase
Taghavi, Amirhossein UL; van der Schoot, Paul; Berryman, Josh UL

in Quarterly Reviews of Biophysics (2017), 50

Using atomistic simulations, we show the formation of stable triplet structure when particular GC-rich DNA duplexes are extended in solution over a timescale of hundreds of nanoseconds, in the presence of ... [more ▼]

Using atomistic simulations, we show the formation of stable triplet structure when particular GC-rich DNA duplexes are extended in solution over a timescale of hundreds of nanoseconds, in the presence of organic salt. We present planar-stacked triplet disproportionated DNA (Σ DNA) as a possible solution phase of the double helix under tension, subject to sequence and the presence of stabilising co-factors. Considering the partitioning of the duplexes into triplets of base pairs as the first step of operation of recombinase enzymes like RecA, we emphasise the structure–function relationship in Σ DNA. We supplement atomistic calculations with thermodynamic arguments to show that codons for ‘phase 1’ amino acids (those appearing early in evolution) are more likely than a lower entropy GC-rich sequence to form triplets under tension. We further observe that the four amino acids supposed (in the ‘GADV world’ hypothesis) to constitute the minimal set to produce functional globular proteins have the strongest triplet-forming propensity within the phase 1 set, showing a series of decreasing triplet propensity with evolutionary newness. The weak form of our observation provides a physical mechanism to minimise read frame and recombination alignment errors in the early evolution of the genetic code. [less ▲]

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See detailAnalysis of Fingerprinting Techniques for Tor Hidden Services
Panchenko, Andriy UL; Mitseva, Asya UL; Henze, Martin et al

in Proceedings of the 24th ACM Computer and Communications Security (ACM CCS) 16th Workshop on Privacy in the Electronic Society (ACM WPES 2017) (2017, October 31)

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See detailAdvanced Interest Flooding Attacks in Named-Data Networking
Signorello, Salvatore UL; Marchal, Samuel; François, Jérôme et al

Scientific Conference (2017, October 30)

The Named-Data Networking (NDN) has emerged as a clean-slate Internet proposal on the wave of Information-Centric Networking. Although the NDN’s data-plane seems to offer many advantages, e.g., native ... [more ▼]

The Named-Data Networking (NDN) has emerged as a clean-slate Internet proposal on the wave of Information-Centric Networking. Although the NDN’s data-plane seems to offer many advantages, e.g., native support for multicast communications and flow balance, it also makes the network infrastructure vulnerable to a specific DDoS attack, the Interest Flooding Attack (IFA). In IFAs, a botnet issuing unsatisfiable content requests can be set up effortlessly to exhaust routers’ resources and cause a severe performance drop to legitimate users. So far several countermeasures have addressed this security threat, however, their efficacy was proved by means of simplistic assumptions on the attack model. Therefore, we propose a more complete attack model and design an advanced IFA. We show the efficiency of our novel attack scheme by extensively assessing some of the state-of-the-art countermeasures. Further, we release the software to perform this attack as open source tool to help design future more robust defense mechanisms. [less ▲]

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See detailSklaverei zur Zeit Diokletians und Konstantins
Binsfeld, Andrea UL

Presentation (2017, October 28)

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See detailDe la révolution à la fin des utopies
Scuto, Denis UL

Article for general public (2017)

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See detailEidgenössische Jugendbefragungen ch-x: Lebensstile, Konsum und Zukunftsperspektiven junger Erwachsener in der Schweiz
Samuel, Robin UL

Speeches/Talks (2017)

Welches sind die aktuellen Wert-, Lebens- und Zukunftsvorstellungen von jungen Erwachsenen in der Schweiz? Welche Rolle nehmen die neuen Medien im Leben der ersten Generation der Digital Natives ein? Was ... [more ▼]

Welches sind die aktuellen Wert-, Lebens- und Zukunftsvorstellungen von jungen Erwachsenen in der Schweiz? Welche Rolle nehmen die neuen Medien im Leben der ersten Generation der Digital Natives ein? Was sind die Erwartungen der jungen Erwachsenen an Familie, Beruf, Religion und Freizeit? Eine neue Studie der Eidgenössischen Jugendbefragungen ch-x geht diesen Fragen nach. Sie stellt u.a. eine erstaunliche Trendstabilität bei den Grundwerten und bei der Einstufung der Wichtigkeit verschiedener Lebensbereiche fest. [less ▲]

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See detailBildung in Not!
Steffgen, Georges UL

Article for general public (2017)

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See detailGuérilla UX, "quick" mais pas "dirty"
Lallemand, Carine UL

Conference given outside the academic context (2017)

Les ressources limitées des projets de conception incitent souvent à appliquer des méthodes UX rapides, low-cost, « quick & dirty ». Mais le « guerilla UX » peut aussi être « quick » sans être « dirty » ... [more ▼]

Les ressources limitées des projets de conception incitent souvent à appliquer des méthodes UX rapides, low-cost, « quick & dirty ». Mais le « guerilla UX » peut aussi être « quick » sans être « dirty », être inspirant, et constituer une alternative valide aux méthodes traditionnelles de design UX. Au-delà des célèbres tests utilisateurs à la mode Starbucks, cette conférence vous présentera de nombreuses alternatives guérilla aux entretiens, questionnaires, observations, en passant aussi par l’idéation, le storyboarding ou le maquettage. Une bonne dose d’inspiration pour se donner les moyens de faire de l’UX quand on n’en a pas les moyens ! [less ▲]

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See detailOn quasitrivial and associative operations
Devillet, Jimmy UL; Couceiro, Miguel; Marichal, Jean-Luc UL

Presentation (2017, October 25)

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See detailLimites juridiques de la traduction – Limites de la traduction juridique
Becker, Katrin UL

Presentation (2017, October 24)

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See detailEthereum: state of knowledge and research perspectives
Tikhomirov, Sergei UL

Scientific Conference (2017, October 24)

Ethereum is a decentralized application platform that allows users to write, deploy, and interact with smart contracts -- programs that encode financial agreements. A peer-to-peer network of mutually ... [more ▼]

Ethereum is a decentralized application platform that allows users to write, deploy, and interact with smart contracts -- programs that encode financial agreements. A peer-to-peer network of mutually distrusting nodes maintains a common view of the state of all accounts and executes smart contracts' code upon request. The global state is stored in a blockchain secured by a proof-of-work consensus mechanism similar to that in Bitcoin. The core value proposition of Ethereum is a Turing-complete programming language that enables implementing complex logic in smart contracts. Decentralized applications without a trusted third party are appealing in many areas, such as financial services, crowdfunding, and gambling. Smart contracts as a research topic contains many unsolved challenges and spans over areas ranging from cryptography, consensus algorithms, and programming languages to governance, ethical, and legal issues. This paper is the first to summarize the state of knowledge in this field. We provide a technical overview of Ethereum and outline open challenges along with proposed solutions. We also mention alternative blockchains with Turing complete programming capabilities. [less ▲]

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See detailVariant-DB: A Tool for Efficiently Exploring Millions of Human Genetic Variants and Their Annotations
Kutzera, Joachim UL; May, Patrick UL

in Da Silveira, Marcos; Pruski, Cédric; Schneider, Reinhard (Eds.) DILS 2017: Data Integration in the Life Sciences (2017, October 24)

Next Generation Sequencing (NGS) allows sequencing of a human genome within hours, enabling large scale applications such as sequencing the genome of each patient in a clinical study. Each individual ... [more ▼]

Next Generation Sequencing (NGS) allows sequencing of a human genome within hours, enabling large scale applications such as sequencing the genome of each patient in a clinical study. Each individual human genome has about 3.5 Million genetic differences to the so called reference genome, the consensus genome of a healthy human. These differences, called variants, determine individual phenotypes, and certain variants are known to indicate disease predispositions. Finding associations from variant patterns and affected genes to these diseases requires combined analysis of variants from multiple individuals and hence, efficient solutions for accessing and filtering the variant data. We present Variant-DB, our in-house database solution that allows such efficient access to millions of variants from hundreds to thousands of individuals. Variant-DB stores individual variant genotypes and annotations. It features a REST-API and a web-based front-end for filtering variants based on annotations, individuals, families and studies. We explain Variant-DB and its front-end and demonstrate how the Variant-DB API can be included in data integration workflows. [less ▲]

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See detailSprachenlernen mit der App iTEO
Kirsch, Claudine UL

Scientific Conference (2017, October 24)

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See detailSpatially Differentiated, Temporally Variegated: The Study of Life Cycles for a Better Understanding of Suburbia in German City Regions
Hesse, Markus UL; Polivka, Jan; Reicher, Christa

in Raumforschung und Raumordnung (2017)

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See detailDeformation Based Curved Shape Representation
Demisse, Girum UL

Doctoral thesis (2017)

Representation and modelling of an objects' shape is critical in object recognition, synthesis, tracking and many other applications in computer vision. As a result, there is a wide range of approaches in ... [more ▼]

Representation and modelling of an objects' shape is critical in object recognition, synthesis, tracking and many other applications in computer vision. As a result, there is a wide range of approaches in formulating representation space and quantifying the notion of similarity between shapes. A similarity metric between shapes is a basic building block in modelling shape categories, optimizing shape valued functionals, and designing a classifier. Consequently, any subsequent shape based computation is fundamentally dependent on the computational efficiency, robustness, and invariance to shape preserving transformations of the defined similarity metric. In this thesis, we propose a novel finite dimensional shape representation framework that leads to a computationally efficient, closed form solution, and noise tolerant similarity distance function. Several important characteristics of the proposed curved shape representation approach are discussed in relation to earlier works. Subsequently, two different solutions are proposed for optimal parameter estimation of curved shapes. Hence, providing two possible solutions for the point correspondence estimation problem between two curved shapes. Later in the thesis, we show that several statistical models can readily be adapted to the proposed shape representation framework for object category modelling. The thesis finalizes by exploring potential applications of the proposed curved shape representation in 3D facial surface and facial expression representation and modelling. [less ▲]

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See detailConfronting the catalytic dark matter encoded by sequenced genomes
Ellens, Kenneth W.; Christian, Nils; Satagopam, Venkata UL et al

in Nucleic Acids Research (2017)

The post-genomic era has provided researchers with a deluge of protein sequences. However, a significant fraction of the proteins encoded by sequenced genomes remains without an identified function. Here ... [more ▼]

The post-genomic era has provided researchers with a deluge of protein sequences. However, a significant fraction of the proteins encoded by sequenced genomes remains without an identified function. Here, we aim at determining how many enzymes of uncertain or unknown function are still present in the Saccharomyces cerevisiae and human proteomes. Using information available in the Swiss-Prot, BRENDA and KEGG databases in combination with a Hidden Markov Model-based method, we estimate that >600 yeast and 2000 human proteins (>30% of their proteins of unknown function) are enzymes whose precise function(s) remain(s) to be determined. This illustrates the impressive scale of the ‘unknown enzyme problem’. We extensively review classical biochemical as well as more recent systematic experimental and computational approaches that can be used to support enzyme function discovery research. Finally, we discuss the possible roles of the elusive catalysts in light of recent developments in the fields of enzymology and metabolism as well as the significance of the unknown enzyme problem in the context of metabolic modeling, metabolic engineering and rare disease research. [less ▲]

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See detailRejection sensitivity as a vulnerability marker for depressive symptom deterioration in men.
De Rubeis, Jannika; Lugo, Ricardo; Witthöft, Michael et al

in PLoS ONE (2017), 12(10), 0185802

Consistent across time and cultures, men and male adolescents older than 14 years of age appear underrepresented in mood disorders, and are far less likely than women to seek psychological help. The much ... [more ▼]

Consistent across time and cultures, men and male adolescents older than 14 years of age appear underrepresented in mood disorders, and are far less likely than women to seek psychological help. The much higher rate of suicide amongst males suggests that depression in men might be underreported. One of the core human motives is to seek acceptance by others and avoid rejection. Rejection Sensitivity (RS) has been conceptualized as the cognitive-affective processing disposition to anxiously expect, readily perceive, and intensely respond to cues of rejection in the behavior of others. RS has been previously linked with the onset and course of depression, but - as yet - has not been investigated longitudinally in a clinical population. We investigated the predictive role of RS to symptom deterioration 6 months after end-of- treatment in 72 male inpatients with depressive spectrum disorder. The BDI was administered at intake, end-of-treatment and 6 month follow-up. RS scores were obtained at intake. Rejection Sensitivity had additional predictive power on BDI scores at 6 months follow-up controlling for BDI scores at end-of-treatment (ΔR2 = .095). The results are discussed in terms of the importance of targeting RS during treatment, and highlight the fact that therapeutic follow-up care is paramount. Future research should investigate possible mediators of the RS- relapse-to-depression association, such as self-blame, rumination, neuroticism, pessimism, emotion dysregulation, and low self-esteem. [less ▲]

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See detailFirst draft genome sequence of a strain belonging to the Zoogloea genus and its gene expression in situ
Muller, Emilie UL; Narayanasamy, Shaman UL; Zeimes, Myriam et al

in Standards in Genomic Sciences (2017), 12(64),

The Gram-negative beta-proteobacterium Zoogloea sp. LCSB751 (LMG 29444) was newly isolated from foaming activated sludge of a municipal wastewater treatment plant. Here, we describe its draft genome ... [more ▼]

The Gram-negative beta-proteobacterium Zoogloea sp. LCSB751 (LMG 29444) was newly isolated from foaming activated sludge of a municipal wastewater treatment plant. Here, we describe its draft genome sequence and annotation together with a general physiological and genomic analysis, as the first sequenced representative of the Zoogloea genus. Moreover, Zoogloea sp. gene expression in its environment is described using metatranscriptomic data obtained from the same treatment plant. The presented genomic and transcriptomic information demonstrate a pronounced capacity of this genus to synthesize poly-β-hydroxyalkanoate within wastewater. [less ▲]

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