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See detailAbsence of regulator of G-protein signaling 4 does not protect against dopamine neuron dysfunction and injury in the mouse 6-hydroxydopamine lesion model of Parkinson's disease
Ashrafi, Amer UL; Garcia, Pierre UL; Kollmus, Heike et al

in Neurobiology of Aging (in press)

Regulator of G-Protein Signaling 4 (RGS4), a member of the RGS family of proteins that inactivate G-proteins, has gained interest as a potential drug target for neurological disorders, such as epilepsy ... [more ▼]

Regulator of G-Protein Signaling 4 (RGS4), a member of the RGS family of proteins that inactivate G-proteins, has gained interest as a potential drug target for neurological disorders, such as epilepsy and Parkinson’s disease (PD). In the case of PD, the main current option for alleviating motor symptoms are dopamine replacement therapies, which have limitations because of side effects, and reduced effectiveness over the long term. Research on new non-dopaminergic PD drug targets has indicated that inhibition of RGS4 could be an effective adjuvant treatment option. The effectiveness of RGS4 inhibition for an array of PD-linked functional and structural neuroprotection endpoints has not yet been demonstrated. Here, we use the 6-Hydroxydopamine (6-OHDA) lesioning model of the nigrostriatal pathway in mice to address this question. We observe, using a battery of behavioral and pathological measures, that mice deficient for RGS4 are not protected from 6-OHDA induced injury, and show enhanced susceptibility in some measures of motor function. Our results suggest that inhibition of RGS4 as a non-dopaminergic target for PD should be approached with caution. [less ▲]

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See detail(Re)shaping Educational Research through ‘Programification’: Institutional Expansion, Change, and Translation in Norway
Zapp, Mike UL; Helgetun, Jo B.; Powell, Justin J W UL

in European Journal of Education (in press), 52

Educational research in Norway has experienced unprecedented structural expansion as well as cognitive shifts over the past two decades, especially due to increased state investments and the strategic use ... [more ▼]

Educational research in Norway has experienced unprecedented structural expansion as well as cognitive shifts over the past two decades, especially due to increased state investments and the strategic use of extensive and multi-year thematic programs to fund research projects. Applying a neo-institutionalist framework, we examine institutionalization dynamics in cultural-cognitive, normative, and regulative dimensions over the past two decades using interviews, research program calls, policy documents, and funding data. In the cultural-cognitive dimension, we find references to the knowledge society, the importance of evidence in policy-making, and ideas of quality, excellence, and relevance. In the normative dimension, we find the introduction of new professional and methodological standards, reflecting broader global patterns of academic and epistemic drift. In the regulative dimension, the strengthened role of both government and the Research Council of Norway is manifest in substantial growth in both funding and large-scale, long-term planning, including thematic choices—evidence of ‘programification’. The importance of external models has grown in an era of internationalization, yet translation occurs at every level of governance of educational research. This results in a specific Norwegian research model, guided by a mode of governance of programs, that maintains social values traditionally strong in Nordic societies. [less ▲]

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See detailAutobiografia ed emigrazione. Ricordare, raccontare, costruire
Cicotti, Claudio UL

Book published by Lang (in press)

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See detailChapter 4:A Survey on The Polytopic Takagi-Sugeno Approach: Application to the Inverted Pendulum
Bezzaoucha, Souad UL; Voos, Holger UL; Darouach, Mohamed

in The Inverted Pendulum: From Theory to New Innovations in Control and Robotics (in press)

This book chapter gives a general scope, states the main results obtained and methods used for the Polytopic Takagi-Sugeno approach with a detailed application to the inverted pendulum. Modeling, observer ... [more ▼]

This book chapter gives a general scope, states the main results obtained and methods used for the Polytopic Takagi-Sugeno approach with a detailed application to the inverted pendulum. Modeling, observer and controller design will be considered. [less ▲]

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See detailIslamic banking development and access to credit
Leon, Florian UL; Weill, Laurent

in Pacific-Basin Finance Journal (in press)

The recent expansion of Islamic banks raises questions on its economic implications. The aim of this paper is to investigate the impact of Islamic banking development on access to credit. We combine data ... [more ▼]

The recent expansion of Islamic banks raises questions on its economic implications. The aim of this paper is to investigate the impact of Islamic banking development on access to credit. We combine data from a unique hand-collected database that covers Islamic banks with firm-level data covering developing and emerging countries over the period of 2006 to 2009. We find that Islamic banking development has overall no impact on credit constraints, while banking development and conventional banking development alleviate obstacles to financing. However Islamic banking development exerts a positive impact on access to credit when conventional banking development is low. Hence we support the view that Islamic banking does not overall alleviate obstacles to financing, but it can act as substitute to conventional banking. [less ▲]

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See detailThe Case for Context-Driven Software Engineering Research
Briand, Lionel UL; Bianculli, Domenico UL; Nejati, Shiva UL et al

in IEEE Software (in press)

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See detailCharacterizations of idempotent discrete uninorms
Couceiro, Miguel; Devillet, Jimmy UL; Marichal, Jean-Luc UL

in Fuzzy Sets & Systems (in press)

In this paper we provide an axiomatic characterization of the idempotent discrete uninorms by means of three conditions only: conservativeness, symmetry, and nondecreasing monotonicity. We also provide an ... [more ▼]

In this paper we provide an axiomatic characterization of the idempotent discrete uninorms by means of three conditions only: conservativeness, symmetry, and nondecreasing monotonicity. We also provide an alternative characterization involving the bisymmetry property. Finally, we provide a graphical characterization of these operations in terms of their contour plots, and we mention a few open questions for further research. [less ▲]

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See detailLe Brexit et les accords mixtes de l'Union européenne
Neframi, Eleftheria UL

in Annuaire Français de Droit International (in press)

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See detailDynamic interplay of language policy, beliefs and pedagogy in a nursery class in Luxembourg
Kirsch, Claudine UL

in Language and Education (in press)

This presentation focuses on the relationship between the language policy, language ideologies and language practices in a nursery class in trilingual Luxembourg. Individual multilingualism is an ... [more ▼]

This presentation focuses on the relationship between the language policy, language ideologies and language practices in a nursery class in trilingual Luxembourg. Individual multilingualism is an educational goal in Luxembourg, a small country in central Europe, and, thus, children learn Luxembourgish from the compulsory nursery school, become literate in German in Year 1 and learn oral and written French from Year 2 and Year 3, respectively. Currently, 62.4% of the children do not speak Luxembourgish on school entry (MENJE 2016). Many speak Portuguese, French or a language of the Balkans. As a result, educational policies focus on the teaching of Luxembourgish from preschool, sometimes at the expense of other languages. Gretsch and Kirsch (2015) developed the app iTEO in order to promote innovative teaching methods that capitalize on the children’s diverse language resources and that promote a dynamic view of bilingualism. This ipad app, which allows for the recording and editing of oral speech, was designed with social-constructivist theories and Bakhtin’s theory of dialogism in mind. This case-study presents the ways in which a preschool teacher’s ideological beliefs influence a child’s language use over a period of two years leading to the child’s understanding of the legitimacy of translanguaging. The focus lies on the interplay between the educational policy focusing on the teaching of Luxembourgish, the teacher’s language ideologies rooted in her multilingual identity and in societal multilingualism, and the child’s experiences of separating languages at home (Kirsch, 2014). The data stem from a qualitative, longitudinal study using a multi-method approach. The study shows that dialogue between teachers, parents, children, policy-makers and researchers can contribute to shifting ideologies and to opening up dynamic languaging spaces. [less ▲]

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See detailDeveloping speaking and pronunciation skills through storytelling on the app iTEO
Kirsch, Claudine UL

in Hood, Philip (Ed.) Teaching Languages Creatively (in press)

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See detailCompte rendu de M. Feyereisen, B.L. Pochon, L'Etat du Grand-Duché de Luxembourg, Promoculture/Larcier, 2015.
Heuschling, Luc UL

in Hemecht : Zeitschrift für Luxemburger Geschichte = Revue d'Histoire Luxembourgeoise (in press)

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See detailPivotal decomposition schemes inducing clones of operations
Couceiro, Miguel; Teheux, Bruno UL

in Contributions to Algebra and Geometry (in press)

We study pivotal decomposition schemes and investigate classes of pivotally decomposable operations. We provide sufficient conditions on pivotal operations that guarantee that the corresponding classes of ... [more ▼]

We study pivotal decomposition schemes and investigate classes of pivotally decomposable operations. We provide sufficient conditions on pivotal operations that guarantee that the corresponding classes of pivotally decomposable operations are clones, and show that under certain assumptions these conditions are also necessary. In the latter case, the pivotal operation together with the constant operations generate the corresponding clone. [less ▲]

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See detailIncreases in well-being in the transition to retirement for unemployed. Catching up with formerly employed persons
Ponomarenko, Valentina; Leist, Anja UL; Chauvel, Louis UL

in Ageing & Society (in press)

This paper examines the extent to which well-being levels change in the transition to retirement depending on transitioning from being employed, unemployed, or economically inactive. Whereas transitioning ... [more ▼]

This paper examines the extent to which well-being levels change in the transition to retirement depending on transitioning from being employed, unemployed, or economically inactive. Whereas transitioning from employment to unemployment has been found to cause a decrease of subjective well-being with more time spent in unemployment, it is not clear how transitioning from unemployment to retirement affects well-being levels. We use the Survey of Health, Ageing and Retirement in Europe to monitor life satisfaction of respondents who retire in between two waves. We portray well-being scores before and after retirement and then identify the change in life satisfaction during the retirement transition using a First Difference model. Results indicate that being unemployed before retirement is associated with an increase in life satisfaction, but presents mainly a catching-up effect compared to employed persons transitioning to retirement. Retirement from labour market inactivity does not lead to significant changes in well-being. Findings are robust to selection into unemployment and country differences. As well-being of unemployed persons recovers after transitioning to retirement, especially the currently unemployed population should be supported to prevent detrimental consequences of economically unfavourable conditions and lower well-being. [less ▲]

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See detailThe Scent of a Smell: An Extensive Comparison between Textual and Structural Smells
Palomba, Fabio; Panichella, Annibale UL; Zaidman, Andy et al

in IEEE Transactions on Software Engineering (in press)

Code smells are symptoms of poor design or implementation choices that have a negative effect on several aspects of software maintenance and evolution, such as program comprehension or change- and fault ... [more ▼]

Code smells are symptoms of poor design or implementation choices that have a negative effect on several aspects of software maintenance and evolution, such as program comprehension or change- and fault-proneness. This is why researchers have spent a lot of effort on devising methods that help developers to automatically detect them in source code. Almost all the techniques presented in literature are based on the analysis of structural properties extracted from source code, although alternative sources of information (e.g., textual analysis) for code smell detection have also been recently investigated. Nevertheless, some studies have indicated that code smells detected by existing tools based on the analysis of structural properties are generally ignored (and thus not refactored) by the developers. In this paper, we aim at understanding whether code smells detected using textual analysis are perceived and refactored by developers in the same or different way than code smells detected through structural analysis. To this aim, we set up two different experiments. We have first carried out a software repository mining study to analyze how developers act on textually or structurally detected code smells. Subsequently, we have conducted a user study with industrial developers and quality experts in order to qualitatively analyze how they perceive code smells identified using the two different sources of information. Results indicate that textually detected code smells are easier to identify and for this reason they are considered easier to refactor with respect to code smells detected using structural properties. On the other hand, the latter are often perceived as more severe, but more difficult to exactly identify and remove. [less ▲]

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See detailKommunale Selbstinszenierung im vorstädtischen Raum. Ein neuer Blick auf Leprosorien des Spätmittelalters und der frühen Neuzeit
Uhrmacher, Martin UL

in Hesse, Christian; Schulte, Daniela; Stercken, Martina (Eds.) Kommunale Selbstinszenierung (in press)

Abstract zur Tagung „Kommunale Selbstinszenierung“ der Internationalen Kommission für Stadtgeschichte, des Schweizerischen Arbeitskreises für Stadtgeschichte und des NCCR 'Mediality. Historical ... [more ▼]

Abstract zur Tagung „Kommunale Selbstinszenierung“ der Internationalen Kommission für Stadtgeschichte, des Schweizerischen Arbeitskreises für Stadtgeschichte und des NCCR 'Mediality. Historical Perspectives' Universität Zürich, 3./4./5. September 2015 Martin Uhrmacher (Universität Luxemburg) „Leprosorien als kommunale Repräsentationsbauten im vorstädtischen Raum. Ein neuer Blick auf eine bisher wenig beachtete städtische Baugattung“ Die vor den Mauern mittelalterlicher und frühneuzeitlicher Städte gelegenen Leprosorien werden heute zumeist noch immer als abgelegene und verborgene Orte der Exklusion angesehen, durch Zäune und Mauern von der Außenwelt getrennt. Dementsprechend wird auch der Baugattung „Leprosorium“ nur wenig architektonischer Wert zugebilligt, wie bspw. im Ausstellungskatalog „Aussatz – Lepra – Hansen-Krankheit: Demnach hatten sie „keinerlei repräsentative Bedeutung, im Gegenteil: eher unauffällig sollten sie sein, verborgen vor dem Blick der Stadtbewohner und Reisenden“. Im 2005 von Monika Escher und Frank G. Hirschmann publizierten Syntheseband „Die urbanen Zentren des hohen und späten Mittelalters“ zur Geschichte mittelalterlicher Städte zwischen Rhein und Maas werden Leprosorien zudem als „nicht wertungsrelevantes“ Urbanitäts- und Zentralitätskriterium“ bezeichnet; begründet mit der angeblichen „Tatsache, daß in der Regel der topographische Bezug zur Stadt gering war“. In der jüngeren Forschung hat sich diese Einschätzung nun grundlegend gewandelt. Leprosorien gelten aufgrund ihrer besonders prominent und exponiert ausgewählten Standorte an Kreuzungen, Brücken und Hauptausfallstraßen als präsente und das städtische Umland prägende kommunale Einrichtungen, die ein fester Bestandteil der städtischen Lebenswelt waren. Sie dienten nicht dazu, ihre Bewohner zu verstecken, sondern waren vielmehr mit Stiftungen und Spenden versehene städtische Einrichtungen, die vom Rat und den Bürgern auch als Prestigeobjekte betrachtet wurden. Anhand ausgewählter Beispiele wird aufgezeigt, wie Leprosorien als Repräsentationsobjekte der Stadtgemeinden auch dem bürgerlichen Selbstverständnis Ausdruck verliehen. [less ▲]

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See detailNeue Staaten – neue Grenzen. Die Rhein-Maas-Mosel-Region zwischen den Grenzbereinigungen des Ancien Régime und der Neuordnung durch den Wiener Kongress (1779 – 1816)
Uhrmacher, Martin UL

in Fickers, Andreas; Franz, Norbert; Laux, Stephan (Eds.) et al Repression, Reform und Neuordnung im Zeitalter der Revolutionen: Die Folgen des Wiener Kongresses für Westeuropa. Tagung und Workshop zum 200. Jahrestag des Abschlusses des Wiener Kongresses (in press)

Abstract Konferenz 200 Jahre Wiener Kongress Martin Uhrmacher Neue Staaten – neue Grenzen. Die Großregion zwischen den Grenzbereinigungen des Ancien Régime und der Neuordnung durch den Wiener Kongress ... [more ▼]

Abstract Konferenz 200 Jahre Wiener Kongress Martin Uhrmacher Neue Staaten – neue Grenzen. Die Großregion zwischen den Grenzbereinigungen des Ancien Régime und der Neuordnung durch den Wiener Kongress (1779 – 1816). Der Vortrag untersucht die Veränderung von Grenzen und Ihre Entwicklung von sich teils überlagernden und durch Enklaven und Gemeinsherrschaften durchsetzten historisch gewachsenen Grenzsäumen hin zu begradigten, fest definierten und teils naturräumlichen Scheidelinien folgenden Staatsgrenzen. In der heutigen Großregion vollzog sich dieser fundamentale Wandel in nur drei Jahrzehnten: Er gliederte die Region vollkommen neu. Zunächst waren es 1779 mit dem Brüsseler Vertrag nach jahrzehntelangen Verhandlungen endlich zu einem Ausgleich zwischen Österreich und Frankreich gekommen, der die Grenzstreitigkeiten beseitigte und neue, begradigte Grenzen exakt festlegte. Ein ähnlicher Vertrag wurde auch zwischen Österreich und Kurtrier abgeschlossen. Doch die als endgültig geplanten Regelungen bestanden nur wenige Jahre: Infolge der französischen Revolution annektierte die französische Republik am 1. Oktober 1795 die österreichischen Niederlande mit dem Herzogtum Luxemburg und kurz darauf auch Kurtrier und die anderen linksrheinischen Territorien. Alle Staaten wurden aufgelöst und gehörten nun zum französischen Staatsgebiet; Teile der alten Grenzen bestanden als Départementsgrenzen weiter. Nach der Absetzung Napoleons beschloss der Wiener Kongress 1815 eine Neuordnung Europas. Doch im Maas-Moselraum blieben mit Ausnahme Frankreichs alle Territorien und Landesherrschaften, die hier seit dem Früh- und Hochmittelalter bestanden hatten verschwunden. Sie wurden ersetzt durch das neu gegründete Großherzogtum Luxemburg und das ebenfalls neu gegründete Königreich der Vereinigten Niederlande sowie durch die preußische Rheinprovinz, die den gesamten östlichen Teil umfasste. Bei der territorialen Neugliederung griff man in Teilen auf die bis 1795 bestehenden Grenzen des alten Herzogtums zurück. In der Schlussakte des Wiener Kongresses behandeln die Artikel 66 bis 69 das Großherzogtum Luxemburg. Hier werden die Grenzen des neuen Staates allerdings nur grob umrissen; detaillierte Regelungen blieben späteren Verträgen vorbehalten. Unstrittig war die Süd- und Westgrenze mit Frankreich; sie entsprach der 1769/79 festgesetzten und bis 1795 gültigen Linie mit Ausnahme des ehemaligen Herzogtums Bouillon als Zugewinn. Vollkommen neu festgelegt wurde jedoch die Ostgrenze: Mit der Schlussakte des Wiener Kongresses waren alle hier an Luxemburg angrenzenden Gebiete an das Königreich Preußen gefallen. In den Verträgen von Aachen (26. Juni 1816) und Kleve (7. Oktober 1816) einigten sich die niederländische und die preußische Seite darauf, dass die Flussläufe von Mosel, Sauer und Our zukünftig die gemeinsame Grenze bildeten. Hier offenbart sich ein grundlegender Wandel im Verständnis und der Genese von Grenzen: Bisher waren territoriale Veränderungen auf Grundlage historisch gewachsener Herrschaftsstrukturen vorgenommen worden. So konnten kleinere Herrschaften aber auch größere Gebietskonglomerate zwar durch Tausch, Verkauf, Abtretung oder - wie durch Frankreich praktiziert - als „Reunionen“ die territoriale Zugehörigkeit wechseln. Dabei wurden jedoch die historisch gewachsenen Grenzen beachtet, sogar noch bei der Einrichtung der französischen Départements 1795. Mit der Wahl des Flußverlaufs von Sauer und Our als Grenze zwischen Luxemburg und Preußen wurde dieses Prinzip durchbrochen und ein naturräumliches Gliederungselement als neu geschaffene Grenze gewählt. [less ▲]

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See detailAre octroyed constitutions of the 19th century to be considered as 'imposed constitutions'?
Gerkrath, Jörg UL

in Contiades, Xenophon (Ed.) ‘Imposed Constitutions: Aspects of Imposed Constitutionalism’ (in press)

The paper considers ‘octroyed’, ‘conceded’ or ‘granted’ constitutions of 19th century Europe whose common roots are to be found in the French ‘Charte constitutionnelle’ of 1814. These Charters stem from a ... [more ▼]

The paper considers ‘octroyed’, ‘conceded’ or ‘granted’ constitutions of 19th century Europe whose common roots are to be found in the French ‘Charte constitutionnelle’ of 1814. These Charters stem from a paternalistic process of domestic constitution-making engaged unilaterally by a monarch possessing the de facto constituent power and exercising it without the direct involvement of a body representing the people. Such octroyed constitutions, which are of course to be opposed to democratically established ones, show nevertheless a number of specific characteristics which distinguish them also from ‘imposed constitutions’ in the usual sense. The expression ‘constitutional octroy’ should not be used as a synonym for any process leading to an ‘imposed Constitution’. The contribution aims to develop and to validate or invalidate the value of a series of distinctive criteria and possible elements of a definition of ‘octroyed’ or ‘granted’ constitutions in order to underline their specificity. [less ▲]

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