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See detailApplication of rare variant transmission disequilibrium tests to epileptic encephalopathy trio sequence data
Allen, Andrew S.; Berkovic, Samuel F.; Bridgers, Joshua et al

in European Journal of Human Genetics (2017)

The classic epileptic encephalopathies, including infantile spasms (IS) and Lennox–Gastaut syndrome (LGS), are severe seizure disorders that usually arise sporadically. De novo variants in genes mainly ... [more ▼]

The classic epileptic encephalopathies, including infantile spasms (IS) and Lennox–Gastaut syndrome (LGS), are severe seizure disorders that usually arise sporadically. De novo variants in genes mainly encoding ion channel and synaptic proteins have been found to account for over 15% of patients with IS or LGS. The contribution of autosomal recessive genetic variation, however, is less well understood. We implemented a rare variant transmission disequilibrium test (TDT) to search for autosomal recessive epileptic encephalopathy genes in a cohort of 320 outbred patient–parent trios that were generally prescreened for rare metabolic disorders. In the current sample, our rare variant transmission disequilibrium test did not identify individual genes with significantly distorted transmission over expectation after correcting for the multiple tests. While the rare variant transmission disequilibrium test did not find evidence of a role for individual autosomal recessive genes, our current sample is insufficiently powered to assess the overall role of autosomal recessive genotypes in an outbred epileptic encephalopathy population. [less ▲]

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See detailNeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases
Blauwendraat, Cornelis; Faghri, Faraz; Pihlstrom, Lasse et al

in Neurobiology of Aging (2017)

Genetics has proven to be a powerful approach in neurodegenerative diseases research, resulting in the identification of numerous causal and risk variants. Previously, we introduced the NeuroX Illumina ... [more ▼]

Genetics has proven to be a powerful approach in neurodegenerative diseases research, resulting in the identification of numerous causal and risk variants. Previously, we introduced the NeuroX Illumina genotyping array, a fast and efficient genotyping platform designed for the investigation of genetic variation in neurodegenerative diseases. Here, we present its updated version, named NeuroChip. The NeuroChip is a low cost, custom-designed array containing a tagging variant backbone of about 306,670 variants complemented with a manually curated custom content comprised of 179,467 variants implicated in diverse neurological diseases, including Alzheimer’s disease, Parkinson’s disease, Lewy body dementia, amyotrophic lateral sclerosis, frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration and multiple system atrophy. The tagging backbone was chosen because of the low cost and good genome-wide resolution; the custom content can be combined with other backbones, like population or drug development arrays. Using the NeuroChip, we can accurately identify rare variants and impute over 5.3 million common SNPs from the latest release of the Haplotype Reference Consortium. In summary, we describe the design and usage of the NeuroChip array, and show its capability for detecting rare pathogenic variants in numerous neurodegenerative diseases. The NeuroChip has a more comprehensive and improved content, which makes it a reliable, high-throughput, cost-effective screening tool for genetic research and molecular diagnostics in neurodegenerative diseases. [less ▲]

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See detail1867, Napoléon III, Bismarck et un record
Scuto, Denis UL

in Tageblatt (2017)

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See detailLuxemburg und der Studiengang der Sozialen Arbeit
Böwen, Petra UL; Dujardin, Céline UL; Straus, Liz UL

Poster (2017, May 10)

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See detailErythritol is a pentose-phosphate pathway metabolite and associated with adiposity gain in young adults
Hootman, Katie C.; Trezzi, Jean-Pierre UL; Kraemer, Lisa UL et al

in Proceedings of the National Academy of Sciences of the United States of America (2017)

Metabolomic markers associated with incident central adiposity gain were investigated in young adults. In a 9-mo prospective study of university freshmen (n = 264). Blood samples and anthropometry ... [more ▼]

Metabolomic markers associated with incident central adiposity gain were investigated in young adults. In a 9-mo prospective study of university freshmen (n = 264). Blood samples and anthropometry measurements were collected in the first 3 d on campus and at the end of the year. Plasma from individuals was pooled by phenotype [incident central adiposity, stable adiposity, baseline hemoglobin A1c (HbA1c) > 5.05%, HbA1c < 4.92%] and assayed using GC-MS, chromatograms were analyzed using MetaboliteDetector software, and normalized metabolite levels were compared using Welch’s t test. Assays were repeated using freshly prepared pools, and statistically significant metabolites were quantified in a targeted GC-MS approach. Isotope tracer studies were performed to determine if the potential marker was an endogenous human metabolite in men and in whole blood. Participants with incident central adiposity gain had statistically significantly higher blood erythritol [P < 0.001, false discovery rate (FDR) = 0.0435], and the targeted assay revealed 15-fold [95% confidence interval (CI): 13.27, 16.25] higher blood erythritol compared with participants with stable adiposity. Participants with baseline HbA1c > 5.05% had 21-fold (95% CI: 19.84, 21.41) higher blood erythritol compared with participants with lower HbA1c (P < 0.001, FDR = 0.00016). Erythritol was shown to be synthesized endogenously from glucose via the pentose-phosphate pathway (PPP) in stable isotope-assisted ex vivo blood incubation experiments and through in vivo conversion of erythritol to erythronate in stable isotope-assisted dried blood spot experiments. Therefore, endogenous production of erythritol from glucose may contribute to the association between erythritol and obesity observed in young adults. [less ▲]

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See detailImmunities of Heads of State and State Officials for International Crimes
Pichou, Maria UL

Presentation (2017, May 08)

This project explores the issue of immunities of Heads of State and State officials for international crimes before international courts and international criminal tribunals and courts. My presentation ... [more ▼]

This project explores the issue of immunities of Heads of State and State officials for international crimes before international courts and international criminal tribunals and courts. My presentation begins with the Rome Statute provisions and the International Criminal Court’s case law on the issue; it then turns to the jurisprudence of the international criminal tribunals and specialised, internationalised, hybrid courts, in an attempt to provide a concise but as far as possible comprehensive analysis; it proceeds with an analysis under public international law and the International Court of Justice (hereinafter ‘ICJ’) case law. As the question of immunities is currently under review at the International Law Commission (hereinafter ‘ILC’), an analysis of the ILC Reports thus far is included. Finally, the project will address the question of how national courts and national law have dealt with Article 27 of the Rome Statute [less ▲]

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See detailAlgorithmic Decision Theory for solving complex decision problems
Bisdorff, Raymond UL

Presentation (2017, May 03)

Today's decision makers in fields ranging from engineering to psychology, from medicine to economics and/or homeland security are faced with remarkable new technologies, huge amounts of information to ... [more ▼]

Today's decision makers in fields ranging from engineering to psychology, from medicine to economics and/or homeland security are faced with remarkable new technologies, huge amounts of information to help them in reaching good decisions, and the ability to share information at unprecedented speeds and quantities. These tools and resources should lead to better decisions. Yet, the tools bring with them daunting new problems: the massive amounts of data available are often incomplete, unreliable and/or distributed and there is great uncertainty in them; interoperating/distributed decision makers and decision making devices need to be coordinated; many sources of data need to be fused into a good decision; information sharing under new cooperation/competition arrangements raises security problems. When faced with such issues, there are few highly efficient algorithms available to support decision makers. The objective of Algorithmic Decision Theory (ADT) is to improve the ability of decision makers to perform well when facing these new challenges and problems through the use of methods from theoretical computer science, in particular algorithmic methods. The primary goal of ADT is hence to explore and develop algorithmic approaches for solving decision problems arising in a variety of applications areas. Examples include, but are not limited to: - Computational tractability/intractability of social consensus and multiple criteria compromise functions; - Improvement of decision support and recommender systems; - Development of automatic decision devices including on-line decision procedures; - Robust decision making; - Learning for multi-agent systems and other on-line decision devices. This presentation will focus more specifically on multiple criteria decision aiding methodology, the actual research field of the author. [less ▲]

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See detailMathematical abilities in elementary school: Do they relate to number–space associations?
Georges, Carrie UL; Hoffmann, Danielle UL; Schiltz, Christine UL

in Journal of Experimental Child Psychology (2017)

Considering the importance of mathematics in Western societies, it is crucial to understand the cognitive processes involved in the acquisition of more complex mathematical skills. The current study ... [more ▼]

Considering the importance of mathematics in Western societies, it is crucial to understand the cognitive processes involved in the acquisition of more complex mathematical skills. The current study, therefore, investigated how the quality of number–space mappings on the mental number line, as indexed by the parity SNARC (spatial–numerical association of response codes) effect, relates to mathematical performances in third- and fourth-grade elementary school children. Mathematical competencies were determined using the “Heidelberger Rechentest,” a standardized German math test assessing both arithmetical and visuospatial math components. Stronger parity SNARC effects significantly related to better arithmetical but not visuospatial math abilities, albeit only in the relatively younger children. These findings highlight the importance of spatial–numerical interactions for arithmetical (as opposed to visuospatial) math skills at the fairly early stages of mathematical development. Differential relations might be explained by the reliance on problem-solving strategies involving number–space mappings only for arithmetic tasks mainly in younger children. [less ▲]

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See detailPushing the Boundaries. New Research on the Activism of EU Supranational Institutions
Howarth, David UL; Roos, Mechthild

in Journal of Contemporary European Research [=JCER] (2017), 13(2), 1007-1024

This contribution introduces the concept of ‘activism’ to the study of EU supranational institutions and their role in EU policy making and European integration. While long present in studies of the Court ... [more ▼]

This contribution introduces the concept of ‘activism’ to the study of EU supranational institutions and their role in EU policy making and European integration. While long present in studies of the Court of Justice of the EU, ‘activism’ has rarely been examined systematically in the context of analyses of other supranational institutions. This contribution offers a definition of ‘supranational institutional activism’, examines its analytical usefulness in relation to other concepts such as ‘entrepreneurship’ and through the lens of a number of political science and EU integration theories and analytical approaches. The specific analytical insights derived from the disciplines of political science, history and legal scholarship of the twelve articles of this special edition on ‘supranational institutional activism’ are also considered. While the powers and roles of EU supranational institutions have been examined in numerous studies, this article presents a concept that can contribute to a more systematic and comprehensive understanding of the contribution of these entities to EU policy making and European integration. [less ▲]

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See detailSpectral-Efficient Model for Multiuser Massive MIMO: Exploiting User Velocity
Vu, Xuan Thang UL; Trinh, Anh Vu; Chatzinotas, Symeon UL et al

in IEEE international Conference on Communications (2017, May)

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See detailOn the Diversity of Partial Relaying Cooperation with Relay Selection in Finite-SNR Regime
Vu, Xuan Thang UL; Chatzinotas, Symeon UL; Ottersten, Björn UL

in IEEE International Conference on Communications (2017, May)

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See detailFinite-SNR analysis for partial relaying cooperation with channel coding and opportunistic relay selection
Vu, Xuan Thang UL; Duhamel, Pierre; Chatzinotas, Symeon UL et al

in EURASIP Journal on Advances in Signal Processing (2017)

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See detailPost-occupancy evaluation of residential buildings in Luxembourgwith centralized and decentralized ventilation systems, focusing onindoor air quality (IAQ). Assessment by questionnaires and physicalmeasurements
Ferreira Silva, Marielle; Maas, Stefan UL; Artur de Souza, Henor et al

in Energy and Buildings (2017), 148

tComplete knowledge about habits of the occupants, including their opinions regarding ventilation sys-tems is an important condition for reducing the consumption of natural resources and improving ... [more ▼]

tComplete knowledge about habits of the occupants, including their opinions regarding ventilation sys-tems is an important condition for reducing the consumption of natural resources and improving indoorcomfort. In addition, uncomforted occupants tend to take measures to improve their situation, whichmay increase energy consumption. Advanced thermal models for buildings can perhaps predict interac-tions between the IAQ determinants, e.g. energy consumption, ventilation and comfort, but do not takeinto account the behavior of residents. By questionnaires and physical measurements this study evalu-ated dwellings equipped partly with centralized and partly with decentralized ventilation systems withheat recovery. This field study involved two post-occupied residential buildings situated in the city ofEsch-sur-Alzette, Luxembourg, during spring season 2015. Thus, both the physical measurements andquestionnaires were considered. The results obtained demonstrated that more than 80% of the residentswere satisfied and the perceived IAQ was judged “normal”, “good” or even “very good”. Furthermore,the measurements performed detected in some cases malfunction of ventilation devices, wherefore theoccupants were unable. [less ▲]

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See detailCryptanalysis, Reverse-Engineering and Design of Symmetric Cryptographic Algorithms
Perrin, Léo Paul UL

Doctoral thesis (2017)

In this thesis, I present the research I did with my co-authors on several aspects of symmetric cryptography from May 2013 to December 2016, that is, when I was a PhD student at the university of ... [more ▼]

In this thesis, I present the research I did with my co-authors on several aspects of symmetric cryptography from May 2013 to December 2016, that is, when I was a PhD student at the university of Luxembourg under the supervision of Alex Biryukov. My research has spanned three different areas of symmetric cryptography. In Part I of this thesis, I present my work on lightweight cryptography. This field of study investigates the cryptographic algorithms that are suitable for very constrained devices with little computing power such as RFID tags and small embedded processors such as those used in sensor networks. Many such algorithms have been proposed recently, as evidenced by the survey I co-authored on this topic. I present this survey along with attacks against three of those algorithms, namely GLUON, PRINCE and TWINE. I also introduce a new lightweight block cipher called SPARX which was designed using a new method to justify its security: the Long Trail Strategy. Part II is devoted to S-Box reverse-engineering, a field of study investigating the methods recovering the hidden structure or the design criteria used to build an S-Box. I co-invented several such methods: a statistical analysis of the differential and linear properties which was applied successfully to the S-Box of the NSA block cipher Skipjack, a structural attack against Feistel networks called the yoyo game and the TU-decomposition. This last technique allowed us to decompose the S-Box of the last Russian standard block cipher and hash function as well as the only known solution to the APN problem, a long-standing open question in mathematics. Finally, Part III presents a unifying view of several fields of symmetric cryptography by interpreting them as purposefully hard. Indeed, several cryptographic algorithms are designed so as to maximize the code size, RAM consumption or time taken by their implementations. By providing a unique framework describing all such design goals, we could design modes of operations for building any symmetric primitive with any form of hardness by combining secure cryptographic building blocks with simple functions with the desired form of hardness called plugs. Alex Biryukov and I also showed that it is possible to build plugs with an asymmetric hardness whereby the knowledge of a secret key allows the privileged user to bypass the hardness of the primitive. [less ▲]

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See detailUsing Selene to Verify your Vote in JCJ
Iovino, Vincenzo UL; Rial Duran, Alfredo UL; Roenne, Peter UL et al

in Workshop on Advances in Secure Electronic Voting (VOTING'17) (2017, April 07)

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See detailDynamic change of the human gastrointestinal microbiome in relation to mucosal barrier effects during chemotherapy and immune ablative intervention
Kaysen, Anne UL

Doctoral thesis (2017)

Numerous studies have demonstrated that the gastrointestinal tract (GIT) microbiota plays important roles for the human host. Since the GIT microbiota interfaces with the immune system and represents a ... [more ▼]

Numerous studies have demonstrated that the gastrointestinal tract (GIT) microbiota plays important roles for the human host. Since the GIT microbiota interfaces with the immune system and represents a first line of defense against infectious agents, interest has grown in whether the GIT microbiota may influence the outcome of different anticancer treatments. In this study, the GIT of pediatric patients with different cancer types as well as adult patients with hematologic malignancies undergoing an allogeneic hematopoietic stem cell transplantation were sampled throughout their treatment. In order to deeply profile not only the composition of the community, but also the functional capacity and expression, recently developed wet- and dry-lab methodologies for integrated multi-omic analyses were applied. The trajectories of the prokaryotic and microeukaryotic GIT communities of the patients were described in detail using 16S, 18S rRNA gene amplicon sequencing, as well as metagenomic and metatranscriptomic shotgun sequencing. Indeed, changes in the GIT microbiome in response to treatment were detected. Some changes that are generally thought to be detrimental for human health were detected during treatment, such as a decrease in alpha-diversity, a decrease in relative abundance of bacteria associated with health-promoting properties (such as Blautia spp., Roseburia spp. and Faecalibacterium spp.), as well as an increase in the relative abundance of antibiotic resistance genes. These changes were more pronounced in the adult hematology patients than in the pediatric patients, which is likely due to the more intensive treatment. Some observations need further investigation in order to explain their implication in human health. For example, in the pediatric patients, lower relative abundance of Akkermansia muciniphila was associated with mucositis and functional gene categories that are linked to bacteriophages or the bacterial defense mechanism against bacteriophages were associated with the overall status of the patient and mucositis development. Importantly, in both cohorts, high inter-individual but also high intra-individual variation in the prokaryotic communities were detected while the microeukaryotic community did not exhibit drastic changes. In conclusion, the employed integrated multi-omics analysis allowed detailed profiling of the GIT community including archaea, bacteria, eukaryotes and viruses as well as the functional potential including antibiotic resistance genes. In the future, analysis of the individual-specific processes within the GIT microbial community of patients throughout treatment might allow to adjust therapy regimens accordingly and improve the overall outcome of the therapy. [less ▲]

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See detailUn débat parlementaire sur la réduction du temps de travail?
Scuto, Denis UL

in Tageblatt (2017)

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See detailValidating PISA 2015 Collaborative Problem Solving: Report
Schweitzer, Nick UL; Herborn, Katharina UL; Mustafic, Maida UL et al

Presentation (2017, March 01)

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