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See detailExperimental design trade-offs for gene regulatory network inference: an in silico study of the yeast Saccharomyces cerevisiae cell cycle
Markdahl, Johan UL; Colombo, Nicolo UL; Thunberg, Johan UL et al

in Proceedings of the 56th IEEE Conference on Decision and Control (in press)

Time-series of high throughput gene sequencing data intended for gene regulatory network (GRN) inference are often short due to the high costs of sampling cell systems. Moreover, experimentalists lack a ... [more ▼]

Time-series of high throughput gene sequencing data intended for gene regulatory network (GRN) inference are often short due to the high costs of sampling cell systems. Moreover, experimentalists lack a set of quantitative guidelines that prescribe the minimal number of samples required to infer a reliable GRN model. We study the temporal resolution of data vs.quality of GRN inference in order to ultimately overcome this deficit. The evolution of a Markovian jump process model for the Ras/cAMP/PKA pathway of proteins and metabolites in the G1 phase of the Saccharomyces cerevisiae cell cycle is sampled at a number of different rates. For each time-series we infer a linear regression model of the GRN using the LASSO method. The inferred network topology is evaluated in terms of the area under the precision-recall curve (AUPR). By plotting the AUPR against the number of samples, we show that the trade-off has a, roughly speaking, sigmoid shape. An optimal number of samples corresponds to values on the ridge of the sigmoid. [less ▲]

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See detailAutomated Test Case Generation as a Many-Objective Optimisation Problem with Dynamic Selection of the Targets
Panichella, Annibale UL; Kifetew, Fitsum; Tonella, Paolo

in IEEE Transactions on Software Engineering (in press)

The test case generation is intrinsically a multi-objective problem, since the goal is covering multiple test targets (e.g., branches). Existing search-based approaches either consider one target at a ... [more ▼]

The test case generation is intrinsically a multi-objective problem, since the goal is covering multiple test targets (e.g., branches). Existing search-based approaches either consider one target at a time or aggregate all targets into a single fitness function (whole-suite approach). Multi and many-objective optimisation algorithms (MOAs) have never been applied to this problem, because existing algorithms do not scale to the number of coverage objectives that are typically found in real-world software. In addition, the final goal for MOAs is to find alternative trade-off solutions in the objective space, while in test generation the interesting solutions are only those test cases covering one or more uncovered targets. In this paper, we present DynaMOSA (Dynamic Many-Objective Sorting Algorithm), a novel many-objective solver specifically designed to address the test case generation problem in the context of coverage testing. DynaMOSA extends our previous many-objective technique MOSA (Many-Objective Sorting Algorithm) with dynamic selection of the coverage targets based on the control dependency hierarchy. Such extension makes the approach more effective and efficient in case of limited search budget. We carried out an empirical study on 346 Java classes using three coverage criteria (i.e., statement, branch, and strong mutation coverage) to assess the performance of DynaMOSA with respect to the whole-suite approach (WS), its archive-based variant (WSA) and MOSA. The results show that DynaMOSA outperforms WSA in 28% of the classes for branch coverage (+8% more coverage on average) and in 27% of the classes for mutation coverage (+11% more killed mutants on average). It outperforms WS in 51% of the classes for statement coverage, leading to +11% more coverage on average. Moreover, DynaMOSA outperforms its predecessor MOSA for all the three coverage criteria in 19% of the classes with +8% more code coverage on average. [less ▲]

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See detailAutobiografia ed emigrazione. Ricordare, raccontare, costruire
Cicotti, Claudio UL

Book published by Lang (in press)

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See detailSpina Bifida
Pit-Ten Cate, Ineke UL

in Llewellyn, C; Ayers, S; McManus, C (Eds.) et al Cambridge Handbook of Psychology, Health, & Medicine (in press)

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See detailNew Directions in Attack Tree Research: Catching up with Industrial Needs
Gadyatskaya, Olga UL; Trujillo Rasua, Rolando UL

in Mauw, Sjouke (Ed.) Proceedings of the 4th International Workshop on Graphical Models for Security (in press)

Attack trees provide a systematic way of characterizing diverse system threats. Their strengths arise from the combination of an intuitive representation of possible attacks and availability of formal ... [more ▼]

Attack trees provide a systematic way of characterizing diverse system threats. Their strengths arise from the combination of an intuitive representation of possible attacks and availability of formal mathematical frameworks for analyzing them in a qualitative or a quantitative manner. Indeed, the mathematical frameworks have become a large focus of attack tree research. However, practical applications of attack trees in industry largely remain a tedious and error-prone exercise. Recent research directions in attack trees, such as attack tree generation, attempt to close this gap and to improve the attack tree state-of-thepractice. In this position paper we outline the recurrent challenges in manual tree design within industry, and we overview the recent research results in attack trees that help the practitioners. For the challenges that have not yet been addressed by the community, we propose new promising research directions. [less ▲]

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See detailIslamic banking development and access to credit
Leon, Florian UL; Weill, Laurent

in Pacific-Basin Finance Journal (in press)

The recent expansion of Islamic banks raises questions on its economic implications. The aim of this paper is to investigate the impact of Islamic banking development on access to credit. We combine data ... [more ▼]

The recent expansion of Islamic banks raises questions on its economic implications. The aim of this paper is to investigate the impact of Islamic banking development on access to credit. We combine data from a unique hand-collected database that covers Islamic banks with firm-level data covering developing and emerging countries over the period of 2006 to 2009. We find that Islamic banking development has overall no impact on credit constraints, while banking development and conventional banking development alleviate obstacles to financing. However Islamic banking development exerts a positive impact on access to credit when conventional banking development is low. Hence we support the view that Islamic banking does not overall alleviate obstacles to financing, but it can act as substitute to conventional banking. [less ▲]

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See detailEfficacy of metacognitive therapy in improving mental health: A meta-analysis of single-case studies
Rochat, Lucien; Manolov, Rumen; Billieux, Joël UL

in Journal of Clinical Psychology (in press)

Context. Metacognitive therapy and one of its treatment components, the attention training technique are increasingly being delivered to improve mental health. Objective. To examine the efficacy of ... [more ▼]

Context. Metacognitive therapy and one of its treatment components, the attention training technique are increasingly being delivered to improve mental health. Objective. To examine the efficacy of metacognitive therapy and/or attention training technique on mental health outcomes from single-case studies. Methods. Fourteen studies (53 patients) were included. The d-statistic for multiple baseline data and the percentage change index were used to compute the effect sizes. Results. Metacognitive therapy has a large effect on depression, anxiety, other psychopathological symptoms, and all outcomes together. Effect sizes were significantly moderated by the number of sessions, the severity and duration of symptoms, and patient gender, but not by study quality or attention training technique when used as a stand-alone treatment. At the follow-up, 77.36% of the individuals were considered recovered or had maintained improvement. Conclusion. Metacognitive therapy and attention training technique strongly contribute to improving mental health outcomes. This study effectively informs evidence-based practice in the clinical milieu. [less ▲]

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See detailFurther exploration of the SUPPS-P Impulsive Behavior Scale’s factor structure: Evidence from a large Hungarian sample
Zsila, Ágnes; Bőthe, Beáta; Demetrovics, Zsolt et al

in Current Psychology (in press)

Background: Impulsivity is a multidimensional construct playing a pervasive role in psychiatry and neuropsychology. Lynam et al. (2006) have developed the 59-item UPPS-P Impulsive Behavior Scale, which ... [more ▼]

Background: Impulsivity is a multidimensional construct playing a pervasive role in psychiatry and neuropsychology. Lynam et al. (2006) have developed the 59-item UPPS-P Impulsive Behavior Scale, which assesses five distinct impulsivity dimensions: positive urgency, negative urgency, lack of perseverance, lack of premeditation, and sensation seeking. The short, 20-item version of the UPPS-P (SUPPS-P; Billieux et al. 2012) has been developed and adapted into several languages, including English, French, Italian, Spanish, and Arabic. The aim of the present study was to test four theoretical models of the SUPPS-P in a large sample of Hungarian adults. Methods: A total of 15,703 participants (64.76% male; Mage = 33.42 years, SD = 11.06) completed the SUPPS-P using an online questionnaire. Results: Confirmatory factor analyses corroborated the first-order five-factor model of impulsivity and a hierarchical model representing three higher-order constructs (urgency, lack of conscientiousness, sensation seeking), whereas the one-factor and three-factor model were not supported. The factor structure of the SUPPS-P preserved the original, theory-driven structure of the UPPS-P model and this instrument demonstrated good internal consistency. Hypersexual behavior consequences were positively associated with most SUPPS-P components, thus criterion validity was also supported. Conclusion: The SUPPS-P had strong psychometric properties that reflected the theoretical structure of the original UPPS-P model, thus it constitutes a theoretically grounded and time saving multidimensional instrument for assessing impulsivity. [less ▲]

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See detailAn Investigation of Compression Techniques to Speed up Mutation Testing
Zhu; Panichella, Annibale UL; Zaidman, Andy

in 11th IEEE Conference on Software Testing, Validation and Verification, 2018 (in press)

Mutation testing is widely considered as a high-end test coverage criterion due to the vast number of mutants it generates. Although many efforts have been made to reduce the computational cost of ... [more ▼]

Mutation testing is widely considered as a high-end test coverage criterion due to the vast number of mutants it generates. Although many efforts have been made to reduce the computational cost of mutation testing, in practice, the scalability issue remains. In this paper, we explore whether we can use compression techniques to improve the efficiency of strong mutation based on weak mutation information. Our investigation is centred around six mutation compression strategies that we have devised. More specifically, we adopt overlapped grouping and Formal Concept Analysis (FCA) to cluster mutants and test cases based on the reachability (code covergae) and necessity (weak mutation) conditions. Moreover, we leverage mutation knowledge (mutation locations and mutation operator types) during compression. To evaluate our method, we conducted a study on 20 open source Java projects using manually written tests. We also compare our method with pure random sampling and weak mutation. The overall results show that mutant compression techniques are a better choice than random sampling and weak mutation in practice: they can effectively speed up strong mutation 6.3 to 94.3 times with an accuracy of >90%. [less ▲]

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See detailPartizipation in Großschutzgebieten - untersucht am Beispiel der Beteiligung an den Workshops zur Erstellung des Rahmenkonzeptes des Biosphärenreservates Bliesgau 2014
Nienaber, Birte UL

in Weber, Friedericke; Weber, Florian; Jenal, Corinna (Eds.) Wohin des Weges? Regionalentwicklung in Großschutzgebieten (in press)

In 2014 a process of public participation was initiated in order to produce a framework concept for the future configuration of the “Biosphere Bliesgau”. This paper presents characteristics of ... [more ▼]

In 2014 a process of public participation was initiated in order to produce a framework concept for the future configuration of the “Biosphere Bliesgau”. This paper presents characteristics of participation, both in general and in large-scale protected areas in particular, and discusses what various forms of participation (ranging from pure information as non-participation to bottom-up partnerships as the strongest form of participation) are possible. The empirical-analytical section of the paper investigates the 2014 process of participation in Biosphere Bliesgau, using publically available protocols and interviews. It can be seen that the top-down process – e. g. involving concrete agreements between individuals or groups – involves the selection of participants – intended or otherwise – and that the highest level of participation could therefore not be achieved. [less ▲]

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See detailLe Brexit et les accords mixtes de l'Union européenne
Neframi, Eleftheria UL

in Annuaire Français de Droit International (in press)

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See detailPivotal decomposition schemes inducing clones of operations
Couceiro, Miguel; Teheux, Bruno UL

in Contributions to Algebra and Geometry (in press)

We study pivotal decomposition schemes and investigate classes of pivotally decomposable operations. We provide sufficient conditions on pivotal operations that guarantee that the corresponding classes of ... [more ▼]

We study pivotal decomposition schemes and investigate classes of pivotally decomposable operations. We provide sufficient conditions on pivotal operations that guarantee that the corresponding classes of pivotally decomposable operations are clones, and show that under certain assumptions these conditions are also necessary. In the latter case, the pivotal operation together with the constant operations generate the corresponding clone. [less ▲]

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See detailThe Scent of a Smell: An Extensive Comparison between Textual and Structural Smells
Palomba, Fabio; Panichella, Annibale UL; Zaidman, Andy et al

in IEEE Transactions on Software Engineering (in press)

Code smells are symptoms of poor design or implementation choices that have a negative effect on several aspects of software maintenance and evolution, such as program comprehension or change- and fault ... [more ▼]

Code smells are symptoms of poor design or implementation choices that have a negative effect on several aspects of software maintenance and evolution, such as program comprehension or change- and fault-proneness. This is why researchers have spent a lot of effort on devising methods that help developers to automatically detect them in source code. Almost all the techniques presented in literature are based on the analysis of structural properties extracted from source code, although alternative sources of information (e.g., textual analysis) for code smell detection have also been recently investigated. Nevertheless, some studies have indicated that code smells detected by existing tools based on the analysis of structural properties are generally ignored (and thus not refactored) by the developers. In this paper, we aim at understanding whether code smells detected using textual analysis are perceived and refactored by developers in the same or different way than code smells detected through structural analysis. To this aim, we set up two different experiments. We have first carried out a software repository mining study to analyze how developers act on textually or structurally detected code smells. Subsequently, we have conducted a user study with industrial developers and quality experts in order to qualitatively analyze how they perceive code smells identified using the two different sources of information. Results indicate that textually detected code smells are easier to identify and for this reason they are considered easier to refactor with respect to code smells detected using structural properties. On the other hand, the latter are often perceived as more severe, but more difficult to exactly identify and remove. [less ▲]

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See detailOn the performance of an overlapping-domain parallelization strategy for Eulerian-Lagrangian Multiphysics software
Pozzetti, Gabriele UL; Besseron, Xavier UL; Rousset, Alban UL et al

in AIP Conference Proceedings ICNAAM 2017 (in press)

In this work, a strategy for the parallelization of a two-way CFD-DEM coupling is investigated. It consists on adopting balanced overlapping partitions for the CFD and the DEM domains, that aims to reduce ... [more ▼]

In this work, a strategy for the parallelization of a two-way CFD-DEM coupling is investigated. It consists on adopting balanced overlapping partitions for the CFD and the DEM domains, that aims to reduce the memory consumption and inter-process communication between CFD and DEM. Two benchmarks are proposed to assess the consistency and scalability of this approach, coupled execution on 252 cores shows that less than 1\% of time is used to perform inter-physics data exchange. [less ▲]

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See detailKommunale Selbstinszenierung im vorstädtischen Raum. Ein neuer Blick auf Leprosorien des Spätmittelalters und der frühen Neuzeit
Uhrmacher, Martin UL

in Hesse, Christian; Schulte, Daniela; Stercken, Martina (Eds.) Kommunale Selbstinszenierung (in press)

Abstract zur Tagung „Kommunale Selbstinszenierung“ der Internationalen Kommission für Stadtgeschichte, des Schweizerischen Arbeitskreises für Stadtgeschichte und des NCCR 'Mediality. Historical ... [more ▼]

Abstract zur Tagung „Kommunale Selbstinszenierung“ der Internationalen Kommission für Stadtgeschichte, des Schweizerischen Arbeitskreises für Stadtgeschichte und des NCCR 'Mediality. Historical Perspectives' Universität Zürich, 3./4./5. September 2015 Martin Uhrmacher (Universität Luxemburg) „Leprosorien als kommunale Repräsentationsbauten im vorstädtischen Raum. Ein neuer Blick auf eine bisher wenig beachtete städtische Baugattung“ Die vor den Mauern mittelalterlicher und frühneuzeitlicher Städte gelegenen Leprosorien werden heute zumeist noch immer als abgelegene und verborgene Orte der Exklusion angesehen, durch Zäune und Mauern von der Außenwelt getrennt. Dementsprechend wird auch der Baugattung „Leprosorium“ nur wenig architektonischer Wert zugebilligt, wie bspw. im Ausstellungskatalog „Aussatz – Lepra – Hansen-Krankheit: Demnach hatten sie „keinerlei repräsentative Bedeutung, im Gegenteil: eher unauffällig sollten sie sein, verborgen vor dem Blick der Stadtbewohner und Reisenden“. Im 2005 von Monika Escher und Frank G. Hirschmann publizierten Syntheseband „Die urbanen Zentren des hohen und späten Mittelalters“ zur Geschichte mittelalterlicher Städte zwischen Rhein und Maas werden Leprosorien zudem als „nicht wertungsrelevantes“ Urbanitäts- und Zentralitätskriterium“ bezeichnet; begründet mit der angeblichen „Tatsache, daß in der Regel der topographische Bezug zur Stadt gering war“. In der jüngeren Forschung hat sich diese Einschätzung nun grundlegend gewandelt. Leprosorien gelten aufgrund ihrer besonders prominent und exponiert ausgewählten Standorte an Kreuzungen, Brücken und Hauptausfallstraßen als präsente und das städtische Umland prägende kommunale Einrichtungen, die ein fester Bestandteil der städtischen Lebenswelt waren. Sie dienten nicht dazu, ihre Bewohner zu verstecken, sondern waren vielmehr mit Stiftungen und Spenden versehene städtische Einrichtungen, die vom Rat und den Bürgern auch als Prestigeobjekte betrachtet wurden. Anhand ausgewählter Beispiele wird aufgezeigt, wie Leprosorien als Repräsentationsobjekte der Stadtgemeinden auch dem bürgerlichen Selbstverständnis Ausdruck verliehen. [less ▲]

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See detailNeue Staaten – neue Grenzen. Die Rhein-Maas-Mosel-Region zwischen den Grenzbereinigungen des Ancien Régime und der Neuordnung durch den Wiener Kongress (1779 – 1816)
Uhrmacher, Martin UL

in Fickers, Andreas; Franz, Norbert; Laux, Stephan (Eds.) et al Repression, Reform und Neuordnung im Zeitalter der Revolutionen: Die Folgen des Wiener Kongresses für Westeuropa. Tagung und Workshop zum 200. Jahrestag des Abschlusses des Wiener Kongresses (in press)

Abstract Konferenz 200 Jahre Wiener Kongress Martin Uhrmacher Neue Staaten – neue Grenzen. Die Großregion zwischen den Grenzbereinigungen des Ancien Régime und der Neuordnung durch den Wiener Kongress ... [more ▼]

Abstract Konferenz 200 Jahre Wiener Kongress Martin Uhrmacher Neue Staaten – neue Grenzen. Die Großregion zwischen den Grenzbereinigungen des Ancien Régime und der Neuordnung durch den Wiener Kongress (1779 – 1816). Der Vortrag untersucht die Veränderung von Grenzen und Ihre Entwicklung von sich teils überlagernden und durch Enklaven und Gemeinsherrschaften durchsetzten historisch gewachsenen Grenzsäumen hin zu begradigten, fest definierten und teils naturräumlichen Scheidelinien folgenden Staatsgrenzen. In der heutigen Großregion vollzog sich dieser fundamentale Wandel in nur drei Jahrzehnten: Er gliederte die Region vollkommen neu. Zunächst waren es 1779 mit dem Brüsseler Vertrag nach jahrzehntelangen Verhandlungen endlich zu einem Ausgleich zwischen Österreich und Frankreich gekommen, der die Grenzstreitigkeiten beseitigte und neue, begradigte Grenzen exakt festlegte. Ein ähnlicher Vertrag wurde auch zwischen Österreich und Kurtrier abgeschlossen. Doch die als endgültig geplanten Regelungen bestanden nur wenige Jahre: Infolge der französischen Revolution annektierte die französische Republik am 1. Oktober 1795 die österreichischen Niederlande mit dem Herzogtum Luxemburg und kurz darauf auch Kurtrier und die anderen linksrheinischen Territorien. Alle Staaten wurden aufgelöst und gehörten nun zum französischen Staatsgebiet; Teile der alten Grenzen bestanden als Départementsgrenzen weiter. Nach der Absetzung Napoleons beschloss der Wiener Kongress 1815 eine Neuordnung Europas. Doch im Maas-Moselraum blieben mit Ausnahme Frankreichs alle Territorien und Landesherrschaften, die hier seit dem Früh- und Hochmittelalter bestanden hatten verschwunden. Sie wurden ersetzt durch das neu gegründete Großherzogtum Luxemburg und das ebenfalls neu gegründete Königreich der Vereinigten Niederlande sowie durch die preußische Rheinprovinz, die den gesamten östlichen Teil umfasste. Bei der territorialen Neugliederung griff man in Teilen auf die bis 1795 bestehenden Grenzen des alten Herzogtums zurück. In der Schlussakte des Wiener Kongresses behandeln die Artikel 66 bis 69 das Großherzogtum Luxemburg. Hier werden die Grenzen des neuen Staates allerdings nur grob umrissen; detaillierte Regelungen blieben späteren Verträgen vorbehalten. Unstrittig war die Süd- und Westgrenze mit Frankreich; sie entsprach der 1769/79 festgesetzten und bis 1795 gültigen Linie mit Ausnahme des ehemaligen Herzogtums Bouillon als Zugewinn. Vollkommen neu festgelegt wurde jedoch die Ostgrenze: Mit der Schlussakte des Wiener Kongresses waren alle hier an Luxemburg angrenzenden Gebiete an das Königreich Preußen gefallen. In den Verträgen von Aachen (26. Juni 1816) und Kleve (7. Oktober 1816) einigten sich die niederländische und die preußische Seite darauf, dass die Flussläufe von Mosel, Sauer und Our zukünftig die gemeinsame Grenze bildeten. Hier offenbart sich ein grundlegender Wandel im Verständnis und der Genese von Grenzen: Bisher waren territoriale Veränderungen auf Grundlage historisch gewachsener Herrschaftsstrukturen vorgenommen worden. So konnten kleinere Herrschaften aber auch größere Gebietskonglomerate zwar durch Tausch, Verkauf, Abtretung oder - wie durch Frankreich praktiziert - als „Reunionen“ die territoriale Zugehörigkeit wechseln. Dabei wurden jedoch die historisch gewachsenen Grenzen beachtet, sogar noch bei der Einrichtung der französischen Départements 1795. Mit der Wahl des Flußverlaufs von Sauer und Our als Grenze zwischen Luxemburg und Preußen wurde dieses Prinzip durchbrochen und ein naturräumliches Gliederungselement als neu geschaffene Grenze gewählt. [less ▲]

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See detailBandes dessinées im Fremdsprachenunterricht Französisch - Annäherung an eine empirisch fundierte Teilbereichsdidaktik
Morys, Nancy UL

Book published by Peter Lang Verlag - Kolloquium Fremdsprachenunterricht (in press)

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See detailAre octroyed constitutions of the 19th century to be considered as 'imposed constitutions'?
Gerkrath, Jörg UL

in Contiades, Xenophon (Ed.) ‘Imposed Constitutions: Aspects of Imposed Constitutionalism’ (in press)

The paper considers ‘octroyed’, ‘conceded’ or ‘granted’ constitutions of 19th century Europe whose common roots are to be found in the French ‘Charte constitutionnelle’ of 1814. These Charters stem from a ... [more ▼]

The paper considers ‘octroyed’, ‘conceded’ or ‘granted’ constitutions of 19th century Europe whose common roots are to be found in the French ‘Charte constitutionnelle’ of 1814. These Charters stem from a paternalistic process of domestic constitution-making engaged unilaterally by a monarch possessing the de facto constituent power and exercising it without the direct involvement of a body representing the people. Such octroyed constitutions, which are of course to be opposed to democratically established ones, show nevertheless a number of specific characteristics which distinguish them also from ‘imposed constitutions’ in the usual sense. The expression ‘constitutional octroy’ should not be used as a synonym for any process leading to an ‘imposed Constitution’. The contribution aims to develop and to validate or invalidate the value of a series of distinctive criteria and possible elements of a definition of ‘octroyed’ or ‘granted’ constitutions in order to underline their specificity. [less ▲]

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