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See detailAbsence of regulator of G-protein signaling 4 does not protect against dopamine neuron dysfunction and injury in the mouse 6-hydroxydopamine lesion model of Parkinson's disease
Ashrafi, Amer UL; Garcia, Pierre UL; Kollmus, Heike et al

in Neurobiology of Aging (in press)

Regulator of G-Protein Signaling 4 (RGS4), a member of the RGS family of proteins that inactivate G-proteins, has gained interest as a potential drug target for neurological disorders, such as epilepsy ... [more ▼]

Regulator of G-Protein Signaling 4 (RGS4), a member of the RGS family of proteins that inactivate G-proteins, has gained interest as a potential drug target for neurological disorders, such as epilepsy and Parkinson’s disease (PD). In the case of PD, the main current option for alleviating motor symptoms are dopamine replacement therapies, which have limitations because of side effects, and reduced effectiveness over the long term. Research on new non-dopaminergic PD drug targets has indicated that inhibition of RGS4 could be an effective adjuvant treatment option. The effectiveness of RGS4 inhibition for an array of PD-linked functional and structural neuroprotection endpoints has not yet been demonstrated. Here, we use the 6-Hydroxydopamine (6-OHDA) lesioning model of the nigrostriatal pathway in mice to address this question. We observe, using a battery of behavioral and pathological measures, that mice deficient for RGS4 are not protected from 6-OHDA induced injury, and show enhanced susceptibility in some measures of motor function. Our results suggest that inhibition of RGS4 as a non-dopaminergic target for PD should be approached with caution. [less ▲]

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See detailA multifactorial and integrative approach to impulsivity in neuropsychology: Insights from the UPPS model of impulsivity
Rochat, Lucien; Billieux, Joël UL; Gagnon, Jean et al

in Journal of Clinical and Experimental Neuropsychology (in press)

Risky and excessive behaviors, such as aggressive and compulsive behaviors, are frequently described in patients with brain damage and have dramatic psychosocial consequences. Although there is strong ... [more ▼]

Risky and excessive behaviors, such as aggressive and compulsive behaviors, are frequently described in patients with brain damage and have dramatic psychosocial consequences. Although there is strong evidence that impulsivity constitutes a key factor at play in these behaviors, the literature about impulsivity in neuropsychology is to date scarce. In addition, examining and understanding these problematic behaviors requires the assumption that impulsivity is a multidimensional construct. Consequently, this article aims at shedding light on frequent risky and excessive behaviors in patients with brain damage by focusing on a unified, comprehensive, and well-validated model, namely, the UPPS model of impulsivity (Whiteside & Lynam, 2001). This model considers impulsivity as a multidimensional construct that includes four facets: urgency, (lack of) premeditation, (lack of) perseverance, and sensation seeking. Furthermore, we discuss the psychological mechanisms underlying the dimensions of impulsivity, as well as the laboratory tasks designed to assess each mechanism and their neural bases. We then present a scale specifically designed to assess these four dimensions of impulsivity in patients with brain damage and examine the data regarding this multidimensional approach to impulsivity in neuropsychology. This review supports the need to adopt a multifactorial and integrative approach toward impulsive behaviors, and the model presented provides a valuable rationale to disentangle the nature of brain systems and mechanisms underlying impulsive behaviors in patients with brain damage. It may also foster further relevant research in the field of impulsivity and improve assessment and rehabilitation of impulsive behaviors in clinical settings. [less ▲]

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See detail(Re)shaping Educational Research through ‘Programification’: Institutional Expansion, Change, and Translation in Norway
Zapp, Mike UL; Helgetun, Jo B.; Powell, Justin J W UL

in European Journal of Education (in press), 52

Educational research in Norway has experienced unprecedented structural expansion as well as cognitive shifts over the past two decades, especially due to increased state investments and the strategic use ... [more ▼]

Educational research in Norway has experienced unprecedented structural expansion as well as cognitive shifts over the past two decades, especially due to increased state investments and the strategic use of extensive and multi-year thematic programs to fund research projects. Applying a neo-institutionalist framework, we examine institutionalization dynamics in cultural-cognitive, normative, and regulative dimensions over the past two decades using interviews, research program calls, policy documents, and funding data. In the cultural-cognitive dimension, we find references to the knowledge society, the importance of evidence in policy-making, and ideas of quality, excellence, and relevance. In the normative dimension, we find the introduction of new professional and methodological standards, reflecting broader global patterns of academic and epistemic drift. In the regulative dimension, the strengthened role of both government and the Research Council of Norway is manifest in substantial growth in both funding and large-scale, long-term planning, including thematic choices—evidence of ‘programification’. The importance of external models has grown in an era of internationalization, yet translation occurs at every level of governance of educational research. This results in a specific Norwegian research model, guided by a mode of governance of programs, that maintains social values traditionally strong in Nordic societies. [less ▲]

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See detailAutomated Test Case Generation as a Many-Objective Optimisation Problem with Dynamic Selection of the Targets
Panichella, Annibale UL; Kifetew, Fitsum; Tonella, Paolo

in IEEE Transactions on Software Engineering (in press)

The test case generation is intrinsically a multi-objective problem, since the goal is covering multiple test targets (e.g., branches). Existing search-based approaches either consider one target at a ... [more ▼]

The test case generation is intrinsically a multi-objective problem, since the goal is covering multiple test targets (e.g., branches). Existing search-based approaches either consider one target at a time or aggregate all targets into a single fitness function (whole-suite approach). Multi and many-objective optimisation algorithms (MOAs) have never been applied to this problem, because existing algorithms do not scale to the number of coverage objectives that are typically found in real-world software. In addition, the final goal for MOAs is to find alternative trade-off solutions in the objective space, while in test generation the interesting solutions are only those test cases covering one or more uncovered targets. In this paper, we present DynaMOSA (Dynamic Many-Objective Sorting Algorithm), a novel many-objective solver specifically designed to address the test case generation problem in the context of coverage testing. DynaMOSA extends our previous many-objective technique MOSA (Many-Objective Sorting Algorithm) with dynamic selection of the coverage targets based on the control dependency hierarchy. Such extension makes the approach more effective and efficient in case of limited search budget. We carried out an empirical study on 346 Java classes using three coverage criteria (i.e., statement, branch, and strong mutation coverage) to assess the performance of DynaMOSA with respect to the whole-suite approach (WS), its archive-based variant (WSA) and MOSA. The results show that DynaMOSA outperforms WSA in 28% of the classes for branch coverage (+8% more coverage on average) and in 27% of the classes for mutation coverage (+11% more killed mutants on average). It outperforms WS in 51% of the classes for statement coverage, leading to +11% more coverage on average. Moreover, DynaMOSA outperforms its predecessor MOSA for all the three coverage criteria in 19% of the classes with +8% more code coverage on average. [less ▲]

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See detailAutobiografia ed emigrazione. Ricordare, raccontare, costruire
Cicotti, Claudio UL

Book published by Lang (in press)

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See detailChapter 4:A Survey on The Polytopic Takagi-Sugeno Approach: Application to the Inverted Pendulum
Bezzaoucha, Souad UL; Voos, Holger UL; Darouach, Mohamed

in The Inverted Pendulum: From Theory to New Innovations in Control and Robotics (in press)

This book chapter gives a general scope, states the main results obtained and methods used for the Polytopic Takagi-Sugeno approach with a detailed application to the inverted pendulum. Modeling, observer ... [more ▼]

This book chapter gives a general scope, states the main results obtained and methods used for the Polytopic Takagi-Sugeno approach with a detailed application to the inverted pendulum. Modeling, observer and controller design will be considered. [less ▲]

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See detailKindheit als praxeologisches Konzept. Von der generationalen Ordnung zu generationierenden Praktiken
Honig, Michael-Sebastian UL

in Budde, Jürgen; Bittner, Martin; Bossen, Andrea (Eds.) et al Konturen einer praxeologischen Erziehungswissenschaft. Theorie - Methodologie - Analyse (in press)

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See detailSpina Bifida
Pit-Ten Cate, Ineke UL

in Llewellyn, C; Ayers, S; McManus, C (Eds.) et al Cambridge Handbook of Psychology, Health, & Medicine (in press)

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See detailTeachers’ assessment competence: Integrating knowledge-, process-, and product-oriented approaches into a competence-oriented conceptual model
Herppich, Stephanie; Praetorius, Anna-Katharina; Hetmanek, Andreas et al

in Teaching and Teacher Education (in press)

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See detailIslamic banking development and access to credit
Leon, Florian UL; Weill, Laurent

in Pacific-Basin Finance Journal (in press)

The recent expansion of Islamic banks raises questions on its economic implications. The aim of this paper is to investigate the impact of Islamic banking development on access to credit. We combine data ... [more ▼]

The recent expansion of Islamic banks raises questions on its economic implications. The aim of this paper is to investigate the impact of Islamic banking development on access to credit. We combine data from a unique hand-collected database that covers Islamic banks with firm-level data covering developing and emerging countries over the period of 2006 to 2009. We find that Islamic banking development has overall no impact on credit constraints, while banking development and conventional banking development alleviate obstacles to financing. However Islamic banking development exerts a positive impact on access to credit when conventional banking development is low. Hence we support the view that Islamic banking does not overall alleviate obstacles to financing, but it can act as substitute to conventional banking. [less ▲]

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See detailThe Case for Context-Driven Software Engineering Research
Briand, Lionel UL; Bianculli, Domenico UL; Nejati, Shiva UL et al

in IEEE Software (in press)

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See detailCharacterizations of idempotent discrete uninorms
Couceiro, Miguel; Devillet, Jimmy UL; Marichal, Jean-Luc UL

in Fuzzy Sets & Systems (in press)

In this paper we provide an axiomatic characterization of the idempotent discrete uninorms by means of three conditions only: conservativeness, symmetry, and nondecreasing monotonicity. We also provide an ... [more ▼]

In this paper we provide an axiomatic characterization of the idempotent discrete uninorms by means of three conditions only: conservativeness, symmetry, and nondecreasing monotonicity. We also provide an alternative characterization involving the bisymmetry property. Finally, we provide a graphical characterization of these operations in terms of their contour plots, and we mention a few open questions for further research. [less ▲]

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See detailLe Brexit et les accords mixtes de l'Union européenne
Neframi, Eleftheria UL

in Annuaire Français de Droit International (in press)

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See detailDynamic interplay of language policy, beliefs and pedagogy in a nursery class in Luxembourg
Kirsch, Claudine UL

in Language and Education (in press)

This presentation focuses on the relationship between the language policy, language ideologies and language practices in a nursery class in trilingual Luxembourg. Individual multilingualism is an ... [more ▼]

This presentation focuses on the relationship between the language policy, language ideologies and language practices in a nursery class in trilingual Luxembourg. Individual multilingualism is an educational goal in Luxembourg, a small country in central Europe, and, thus, children learn Luxembourgish from the compulsory nursery school, become literate in German in Year 1 and learn oral and written French from Year 2 and Year 3, respectively. Currently, 62.4% of the children do not speak Luxembourgish on school entry (MENJE 2016). Many speak Portuguese, French or a language of the Balkans. As a result, educational policies focus on the teaching of Luxembourgish from preschool, sometimes at the expense of other languages. Gretsch and Kirsch (2015) developed the app iTEO in order to promote innovative teaching methods that capitalize on the children’s diverse language resources and that promote a dynamic view of bilingualism. This ipad app, which allows for the recording and editing of oral speech, was designed with social-constructivist theories and Bakhtin’s theory of dialogism in mind. This case-study presents the ways in which a preschool teacher’s ideological beliefs influence a child’s language use over a period of two years leading to the child’s understanding of the legitimacy of translanguaging. The focus lies on the interplay between the educational policy focusing on the teaching of Luxembourgish, the teacher’s language ideologies rooted in her multilingual identity and in societal multilingualism, and the child’s experiences of separating languages at home (Kirsch, 2014). The data stem from a qualitative, longitudinal study using a multi-method approach. The study shows that dialogue between teachers, parents, children, policy-makers and researchers can contribute to shifting ideologies and to opening up dynamic languaging spaces. [less ▲]

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See detailDeveloping speaking and pronunciation skills through storytelling on the app iTEO
Kirsch, Claudine UL

in Hood, Philip (Ed.) Teaching Languages Creatively (in press)

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See detailCompte rendu de M. Feyereisen, B.L. Pochon, L'Etat du Grand-Duché de Luxembourg, Promoculture/Larcier, 2015.
Heuschling, Luc UL

in Hemecht : Zeitschrift für Luxemburger Geschichte = Revue d'Histoire Luxembourgeoise (in press)

Detailed reference viewed: 15 (1 UL)