Reference : The plexus model for the inference of ancestral multidomain proteins.
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/929
The plexus model for the inference of ancestral multidomain proteins.
English
Wiedenhoeft, John [> >]
Krause, Roland mailto [Freie Universit├Ąt Berlin > Computer Science]
Eulenstein, Oliver [> >]
2011
IEEE/ACM Transactions on Computational Biology and Bioinformatics
8
4
890-901
Yes (verified by ORBilu)
International
1545-5963
1557-9964
United States
[en] Algorithms ; Computational Biology/methods ; Evolution, Molecular ; Models, Biological ; Phylogeny ; Protein Structure, Tertiary ; Proteins/chemistry/genetics
[en] Interactions of protein domains control essential cellular processes. Thus, inferring the evolutionary histories of multidomain proteins in the context of their families can provide rewarding insights into protein function. However, methods to infer these histories are challenged by the complexity of macroevolutionary events. Here, we address this challenge by describing an algorithm that computes a novel network-like structure, called plexus, which represents the evolution of domains and their combinations. Finally, we demonstrate the performance of this algorithm with empirical data sets.
http://hdl.handle.net/10993/929
10.1109/TCBB.2011.22

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