References of "2008"
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See detailInterfence mitigation and synchronization for satellite communications
Grotz, Joel UL

Doctoral thesis (2008)

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See detailReachability analysis of continuous-time piecewise affine systems
Hamadeh, A. O.; Goncalves, Jorge UL

in Automatica (2008), 44(12), 3189-3194

This paper proposes an algorithm for the characterization of reachable sets of states for continuous-time piecewise affine systems. Given a model of the system and a bounded set of possible initial states ... [more ▼]

This paper proposes an algorithm for the characterization of reachable sets of states for continuous-time piecewise affine systems. Given a model of the system and a bounded set of possible initial states, the algorithm employs an LMI approach to compute both upper and lower bounds on reachable regions. Rather than performing computations in the state-space, this method uses impact maps to find the reachable sets on the switching surfaces of the system. This tool can then be used to deduce safety and performance results about the system. [less ▲]

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See detailNecessary and sufficient conditions for dynamical structure reconstruction of LTI networks
Goncalves, Jorge UL; Warnick, S.

in IEEE Transactions on Automatic Control (2008), 53(7), 1670-1674

This paper formulates and solves the network reconstruction problem for linear time-invariant systems. The problem is motivated from a variety of disciplines, but it has recently received considerable ... [more ▼]

This paper formulates and solves the network reconstruction problem for linear time-invariant systems. The problem is motivated from a variety of disciplines, but it has recently received considerable attention from the systems biology community in the study of chemical reaction networks. Here, we demonstrate that even when a transfer function can be identified perfectly from input–output data, not even Boolean reconstruction is possible, in general, without more information about the system.We then completely characterize this additional information that is essential for dynamical reconstruction without appeal to ad-hoc assumptions about the network, such as sparsity or minimality. [less ▲]

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See detailComputational representation and hemodynamic characterization of in vivo acquired severe stenotic renal artery geometries using turbulence modeling
Kagadis, George; Skouras, Eugene; Bourantas, Georgios UL et al

in Medical Engineering & Physics (2008), 30(5), 647-660

The present study reports on computational fluid dynamics in the case of severe renal artery stenosis (RAS). An anatomically realistic model of a renal artery was reconstructed from CT scans, and used to ... [more ▼]

The present study reports on computational fluid dynamics in the case of severe renal artery stenosis (RAS). An anatomically realistic model of a renal artery was reconstructed from CT scans, and used to conduct CFD simulations of blood flow across RAS. The recently developed Shear Stress Transport turbulence model was pivotally applied in the simulation of blood flow in the region of interest. Blood flow was studied in vivo under the presence of RAS and subsequently in simulated cases before the development of RAS, and after endovascular stent implantation. The pressure gradients in the RAS case were many orders of magnitude larger than in the healthy case. The presence of RAS increased flow resistance, which led to considerably lower blood flow rates. A simulated stent in place of the RAS decreased the flow resistance at levels proportional to, and even lower than, the simulated healthy case without the RAS. The wall shear stresses, differential pressure profiles, and net forces exerted on the surface of the atherosclerotic plaque at peak pulse were shown to be of relevant high distinctiveness, so as to be considered potential indicators of hemodynamically significant RAS. [less ▲]

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See detailBimodal and hysteretic expression in mammalian cells from a synthetic gene circuit
May, T.; Eccleston, L. J.; Markusic, D. et al

in Public Library of Science ONE (2008), 3(6),

In order to establish cells and organisms with predictable properties, synthetic biology makes use of controllable, synthetic genetic devices. These devices are used to replace or to interfere with ... [more ▼]

In order to establish cells and organisms with predictable properties, synthetic biology makes use of controllable, synthetic genetic devices. These devices are used to replace or to interfere with natural pathways. Alternatively, they may be interlinked with endogenous pathways to create artificial networks of higher complexity. While these approaches have been already successful in prokaryotes and lower eukaryotes, the implementation of such synthetic cassettes in mammalian systems and even animals is still a major obstacle. This is mainly due to the lack of methods that reliably and efficiently transduce synthetic modules without compromising their regulation properties. To pave the way for implementation of synthetic regulation modules in mammalian systems we utilized lentiviral transduction of synthetic modules. A synthetic positive feedback loop, based on the Tetracycline regulation system was implemented in a lentiviral vector system and stably integrated in mammalian cells. This gene regulation circuit yields a bimodal expression response. Based on experimental data a mathematical model based on stochasticity was developed which matched and described the experimental findings. Modelling predicted a hysteretic expression responsewhich was verified experimentally. Thereby supporting the idea that the system is driven by stochasticity. The results presented here highlight that the combination of three independent tools/methodologies facilitate the reliable installation of synthetic gene circuits with predictable expression characteristics in mammalian cells and organisms. [less ▲]

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See detailZwei IT-Sicherheitsmethoden im Vergleich: Mehari versus BSI IT-Grundschutz
Dagorn, Nathalie; Schiltz, Jang UL

E-print/Working paper (2008)

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See detailThe smoothed extended finite element method
Natarajan, S.; Bordas, Stéphane UL; Minh, Q. D. et al

in Proceedings of the 6th International Conference on Engineering Computational Technology (2008)

This paper shows how the strain smoothing technique recently proposed by G.R.Liu [1] coined as smoothed finite element method (SFEM) can be coupled to partition of unity methods, namely extended finite ... [more ▼]

This paper shows how the strain smoothing technique recently proposed by G.R.Liu [1] coined as smoothed finite element method (SFEM) can be coupled to partition of unity methods, namely extended finite element method (XFEM) [2] to give birth to the smoothed extended finite element method (SmXFEM), which shares properties both with the SFEM and the XFEM. The proposed method suppresses the need to compute and integrate the derivatives of shape functions (which are singular at the tip in linear elastic fracture mechanics). Additionally, integration is performed along the boundary of the finite elements or smoothing cells and no isoparametric mapping is required, which allows elements of arbitrary shape. We present numerical results for cracks in linear elastic fracture mechanics problems. The method is verified on several examples and comparisons are made to the conventional XFEM. © 2008 Civil-Comp Press. [less ▲]

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See detailA posteriori error estimation for extended finite elements by an extended global recovery
Duflot, M.; Bordas, Stéphane UL

in International Journal for Numerical Methods in Engineering (2008), 76(8), 1123-1138

This contribution presents an extended global derivative recovery for enriched finite element methods (FEMs), such as the extended FEM along with an associated error indicator. Owing to its simplicity ... [more ▼]

This contribution presents an extended global derivative recovery for enriched finite element methods (FEMs), such as the extended FEM along with an associated error indicator. Owing to its simplicity, the proposed scheme is ideally suited to industrial applications. The procedure is based on global minimization of the L2 norm of the difference between the raw strain field (C-1) and the recovered (C0) strain field. The methodology engineered in this paper extends the ideas of Oden and Brauchli (Int. J. Numer. Meth. Engng 1971; 3) and Hinton and Campbell (Int. J. Numer. Meth. Engng 1974; 8) by enriching the approximation used for the construction of the recovered derivatives (strains) with the gradients of the functions employed to enrich the approximation employed for the primal unknown (displacements). We show linear elastic fracture mechanics examples, both in simple two-dimensional settings, and for a three-dimensional structure. Numerically, we show that the effectivity index of the proposed indicator converges to unity upon mesh refinement. Consequently, the approximate error converges to the exact error, indicating that the error indicator is valid. Additionally, the numerical examples suggest a novel adaptive strategy for enriched approximations in which the dimensions of the enrichment zone are first increased, before standard h- and p-adaptivities are applied; we suggest to coin this methodology e-adaptivity. Copyright © 2008 John Wiley & Sons, Ltd. [less ▲]

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See detailTimeWarp: Interactive Time Travel with a Mobile Mixed Reality Game
Herbst, Iris; Braun, Anne-Kathrine; McCall, Roderick UL et al

in In the Proceedings of MobileHCI 2008, Amsterdam, Netherlands (2008)

Mobile location-aware applications have become quite popular across a range of new areas such as pervasive games and mobile edutainment applications. However it is only recently, that approaches have been ... [more ▼]

Mobile location-aware applications have become quite popular across a range of new areas such as pervasive games and mobile edutainment applications. However it is only recently, that approaches have been presented which combine gaming and education with mobile Augmented Reality systems. However they typically lack a close crossmedia integration of the surroundings, and often annotate or extend the environment rather than modifying and altering it. In this paper we present a mobile outdoor mixed reality game for exploring the history of a city in the spatial and the temporal dimension. We introduce the design and concept of the game and present a universal mechanism to define and setup multi-modal user interfaces for the game challenges. Finally we discuss the results of the user tests. [less ▲]

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See detailNumerische Untersuchungen der instationären Strömungstopologie im Nachlauf einer Seehundvibrisse
Witte, Matthias; Michael, Mark UL; Brede, Martin et al

in Ruck, B.; Leder, A.; Dopheide, D. (Eds.) Proceedings der 16.GALA-Fachtagung “Lasermethoden in der Strömungsmesstechnik“ (2008)

Im Rahmen des Schwerpunktprogramms 1207 „Strömungen in Natur und Technik“ wird die Umströmung einer Seehundvibrisse untersucht. Die Vibrissen von Seehunden zeichnen sich durch eine komplizierte ... [more ▼]

Im Rahmen des Schwerpunktprogramms 1207 „Strömungen in Natur und Technik“ wird die Umströmung einer Seehundvibrisse untersucht. Die Vibrissen von Seehunden zeichnen sich durch eine komplizierte dreidimensionale Strukturmodellierung aus. Sie versetzen den See- hund in die Lage, Nachlaufspuren von Beutefischen zu detektieren. Mit Hilfe Stereo- μ Piv Messungen an Seehundvibrissen konnte die stationäre Strömungstopologie des Vibrissen- nachlaufes ermittelt werden. Zum besseren Verständnis der Funktion der Strukturierung der Vibrisse ist es notwendig, die instationäre Strömungstopologie zu kennen. Durch räumlich und zeitlich hochauflösende numerische Verfahren soll die instationäre Strömungstopologie im Nachlauf einer Seehundvibrisse ermittelt werden. [less ▲]

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See detailComparison of recently developed recovery type discretization error estimators for the extended finite element method
Ródenas, J. J.; Duflot, Marc; Bordas, Stéphane UL et al

in Schrefler, B A; Perego, U (Eds.) 8th World Congress on Computational Mechanics (WCCM8). 5th.European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2008) (2008)

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See detailBatch control of the master equation: a linear programming approach
Goncalves, Jorge UL; Martins, N.

Scientific Conference (2008)

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See detailDynamical structure analysis of sparsity and minimality heuristics for reconstruction of biochemical networks
Howes, R.; Eccleston, L. J.; Goncalves, Jorge UL et al

in The proceedings of the 47th IEEE Conference on Decision and Control (2008)

Network reconstruction, i.e. obtaining network structure from input-output information, is a central theme in systems biology. A variety of approaches aim to obtaining structural information from ... [more ▼]

Network reconstruction, i.e. obtaining network structure from input-output information, is a central theme in systems biology. A variety of approaches aim to obtaining structural information from available data. Previous work has introduced dynamical structure functions as a tool for posing and solving the network reconstruction problem. Even for linear time invariant systems, reconstruction requires specific additional information not generated in the typical system identification process. This paper demonstrates that such extra information can be obtained through a limited sequence of system identification experiments on structurally modified systems, analogous to gene silencing and overexpression experiments. In the absence of such extra information, we discuss whether combined assumptions of network sparsity and minimality contribute to the recovery of the network dynamical structure. We provide sufficient conditions for a transfer function to have a completely decoupled minimal realization, and demonstrate that every transfer function is arbitrarily close to one that admits a perfectly decoupled minimal realization. This indicates that the assumptions of sparsity and minimality alone do not lend insight into the network structure. [less ▲]

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See detailRobust synchronization in networks of cyclic feedback systems
Hamadeh, A. O.; Goncalves, Jorge UL; Stan, G. B. V.

in The proceedings of the 47th IEEE Conference on Decision and Control (2008)

This paper presents a result on the robust synchronization of outputs of statically interconnected non-identical cyclic feedback systems that are used to model, among other processes, gene expression. The ... [more ▼]

This paper presents a result on the robust synchronization of outputs of statically interconnected non-identical cyclic feedback systems that are used to model, among other processes, gene expression. The result uses incremental versions of the small gain theorem and dissipativity theory to arrive at an upper bound on the norm of the synchronization error between corresponding states, giving a measure of the degree of convergence of the solutions. This error bound is shown to be a function of the difference between the parameters of the interconnected systems, and disappears in the case where the systems are identical, thus retrieving an earlier synchronization result. [less ▲]

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See detailControl theory methods for macro models with stochastic micro foundations
Tonita, R. J.; Goncalves, Jorge UL; Lestas, I. C. et al

Scientific Conference (2008)

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See detailGlobal asymptotic stability of the limit cycle in piecewise linear versions of the Goodwin oscillator
Salinas Varela, A. A.; Stan, G. B. V.; Goncalves, Jorge UL

in Proceedings of the 17th IFAC World Congress (2008)

Conditions in the form of linear matrix inequalities (LMIs) are used in this paper to guarantee the global asymptotic stability of a limit cycle oscillation for a class of piecewise linear (PWL) systems ... [more ▼]

Conditions in the form of linear matrix inequalities (LMIs) are used in this paper to guarantee the global asymptotic stability of a limit cycle oscillation for a class of piecewise linear (PWL) systems defined as the feedback interconnection of a saturation controller with a single input, single output (SISO) linear time-invariant (LTI) system. The proposed methodology extends previous results on impact maps and surface Lyapunov functions to the case when the sets of expected switching times are arbitrarily large. The results are illustrated on a PWL version of the Goodwin oscillator. [less ▲]

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See detailHeterogeneous agent models in economics: a study of heterogeneous productivity of sectors
Tonita, R. J.; Goncalves, Jorge UL; Vinnicombe, G.

in Proceedings of the 2008 American Control Conference (2008)

Macroeconomic modeling is undergoing a change from the ground up. Previously models based on fully rational representative agents were constructed to give macroeconomics soli microeconomic foundations ... [more ▼]

Macroeconomic modeling is undergoing a change from the ground up. Previously models based on fully rational representative agents were constructed to give macroeconomics soli microeconomic foundations. However the representative agent models have been shown to be inconsistent with empirical evidence and a new method of approach has emerged, one based on heterogeneity of agents. Recently heterogenous models have been used to simulate expected outcomes but due to their complexity little analytic work has been done. In this paper a basic model of the macro economy, with heterogeneous sectors differentiated by productivity, and driven by a jump Markov process, is investigated and steady state solutions for a sector’s output variance are discovered. We adjust the model to include a gain term, to represent a sector’s reaction to its error signal, excess demand, and then linearize the transition rates and apply the fluctuation dissipation theorem to solve the model. [less ▲]

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See detailRobustness analysis of cellular systems for in silico drug discovery
Perumal, Thanneer Malai UL; Wu, Y.; Gunawan, R.

Scientific Conference (2008)

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