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See detailUse of commercial simulation software for analyzing the dynamics of an injection-molding clamp unit
Hostert, Claude UL

Doctoral thesis (2006)

Today, the interest in integrated dynamic analysis of mechatronic systems increases. Different approaches are possible depending on the nature of the system, on the required complexity of the model, or ... [more ▼]

Today, the interest in integrated dynamic analysis of mechatronic systems increases. Different approaches are possible depending on the nature of the system, on the required complexity of the model, or simply on the tools available to the engineer. During this work, the aim was to implement specialized commercial simulation software packages and to combine them in order to simulate the dynamic behavior of mechatronic systems as for example an injection molding machine. The multi-body simulation software is the backbone of the current analysis as it inherently models large non-linear motions. It is possible to account for the flexibility of components in the MBS model if necessary. Furthermore, other simulation codes were used to model the hydraulic and controls systems. The case studies show the interest and the potential of a combined analysis of mechatronic systems. Once the different sub-models, generated with the adequate simulation tool, have been successfully linked and validated by measurements, various scenarios can be simulated and analyzed. The model provides the engineer with an additional insight into the overall system and thus with a better understanding of its dynamic characteristics. The interactions between the subsystems, which may be of very distinctive nature, can be investigated. Generally, it is difficult to predict such relations intuitively. Finally, the model allows to simulate with different design parameters and to asses the effect of modifications to these on the overall performance of the machine. This helps to identify the significant parameters that are crucial for an optimized functioning. [less ▲]

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See detailProcess Reference Model "IT Grundschutz"
Asselborn, Jean-Claude; Dagorn, Nathalie; Niederkorn, Philippe et al

Report (2006)

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See detailProcess Reference Model "Mehari"
Asselborn, Jean-Claude; Dagorn, Nathalie; Niederkorn, Philippe et al

Report (2006)

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See detailAnalyse prozessbezogener Einflussfaktoren zur Steigerung der Robustheit von Produktenwicklungsprojekten
Gericke, Kilian UL; Blessing, Lucienne UL

in Proceedings of 17th Symposium Design for X (2006)

Auf Basis des Konzeptes der Robustheit von Produktentwicklungsprojekten werden Effekte dargelegt, die zu Planungsabweichungen führen. Das Konzept wird durch eine Diskussion der Erfolgskriterien von ... [more ▼]

Auf Basis des Konzeptes der Robustheit von Produktentwicklungsprojekten werden Effekte dargelegt, die zu Planungsabweichungen führen. Das Konzept wird durch eine Diskussion der Erfolgskriterien von Projekten und möglichen Ansatzpunkten zur Steigerung der Robustheit umrissen. Als Ergebnis einer Literaturstudie wurden Problemschwerpunkte hinsichtlich der Ursachen von Planungsabweichungen und deren Erscheinungsformen identifiziert. Auf Grundlage dieser Studien lassen sich jedoch keine Ansätze zur Steigerung der Robustheit von Produktentwicklungsprojekten ableiten. Die Betrachtung der Studien bildet den Ausgangspunkt für eigene Untersuchungen, die zu einem besseren Verständnis der Ursachen von Planungsabweichungen in Produktentwicklungsprojekten und zur Ableitung von Handlungsempfehlungen führen sollen. [less ▲]

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See detailOn L2 error bounds between systems
Salinas, A.; Papachristodoulou, A.; Goncalves, Jorge UL

Scientific Conference (2006)

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See detailRhythmic regulation of Ca2+ signalling networks
Gardner, M.; Hotta, C.; Hubbard, K. et al

Scientific Conference (2006)

The circadian clock is the internal timekeeper of plants. This clock regulates most aspects of plant physiology providing considerable competitive advantage. We are investigating the role for oscillations ... [more ▼]

The circadian clock is the internal timekeeper of plants. This clock regulates most aspects of plant physiology providing considerable competitive advantage. We are investigating the role for oscillations in the cytosolic free Ca2+ concentration ([Ca2+]cyt) in the circadian control of cellular physiology. We have previously demonstrated that circadian oscillations of [Ca2+]cyt encode photoperiodic information but the precise role of circadian [Ca2+]cyt oscillations remain obscure. We have been taking a systems wide approach to determine the origin and function of circadian oscillations of [Ca2+]cyt. Using pharmacology, bioinformatics and biochemical tools we have new evidence that oscillations of [Ca2+]cyt are generated by the small signalling intermediate, cADPR. Positioning the oscillations of [Ca2+]cyt with respect to the molecular oscillator using reverse genetics indicates that [Ca2+]cyt is an output of the clock. Using a whole genome transcriptional profile we have identified over 1800 circadian-regulated transcripts, many of which encode for Ca2+ signalling elements. The function of circadian-regulated transcripts encoding signalling components is being investigated by reverse genetic screens with automated imaging. Using our extensive data sets describing the circadian regulation of [Ca2+]cyt in different backgrounds and conditions we have constructed a mathematical model. This is being validated using mutant analysis and refined by introducing complexity to the model. Our data and models suggest that [Ca2+]cyt acts an output of the clock that regulates diverse aspects of physiology and has the potential to form a feedback loop with the molecular components of the oscillator. [less ▲]

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See detailApplying dynamic Bayesian networks to perturbed gene expression data
Norbert, Dojer; Gambin, Anna; Mizera, Andrzej UL et al

in BMC Bioinformatics (2006), 7

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See detailClinical data based optimal STI strategies for HIV: a reinforcement learning approach
Ernst, D.; Stan, G.B.; Goncalves, Jorge UL et al

in Proceedings of the IEEE Conference on Decision and Control (2006)

This paper addresses the problem of computing optimal structured treatment interruption strategies for HIV infected patients. We show that reinforcement learning may be useful to extract such strategies ... [more ▼]

This paper addresses the problem of computing optimal structured treatment interruption strategies for HIV infected patients. We show that reinforcement learning may be useful to extract such strategies directly from clinical data, without the need of an accurate mathematical model of HIV infection dynamics. To support our claims, we report simulation results obtained by running a recently proposed batch-mode reinforcement learning algorithm, known as fitted Q iteration, on numerically generated data. [less ▲]

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