Reference : Sodium butyrate improves memory function in an Alzheimer's disease mouse model when a...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/8124
Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression
English
Govindarajan, Nambirajan []
Agis-Balboa, Roberto Carlos []
Walter, Jonas mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Sananbenesi, Farahnaz []
Fischer, André []
1-Jan-2011
Journal of Alzheimer's Disease [=JAD]
IOS Press
26
1
187-197
Yes (verified by ORBilu)
International
1387-2877
[en] Alzheimer's Disease ; Sodium butyrate ; memory function
[en] Dysregulation of histone acetylation has been implicated in the onset of age-associated memory impairment and the pathogenesis of neurodegenerative diseases. Elevation of histone acetylation via administration of histone deacetylase (HDAC) inhibitors is currently being pursued as a novel therapeutic avenue to treat memory impairment linked to Alzheimer's disease (AD). Here we show that severe amyloid pathology correlates with a pronounced dysregulation of histone acetylation in the forebrain of APPPS1-21 mice. Importantly, prolonged treatment with the pan-HDAC inhibitor sodium butyrate improved associative memory in APPPS1-21 mice even when administered at a very advanced stage of pathology. The recovery of memory function correlated with elevated hippocampal histone acetylation and increased expression of genes implicated in associative learning. These data advance our understanding of the potential applicability of HDAC inhibitors for the treatment of AD and suggest that HDAC inhibitors may have beneficial effects even when administered long after the onset of disease-associated symptoms.
European Neuroscience Institute Goettingen, University Medicine Goettingen, Goettingen, Germany.
http://hdl.handle.net/10993/8124

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Limited access
Govindarajan et al-2011.pdfPublisher postprint702.58 kBRequest a copy

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.