Reference : The dynamic genetic repertoire of microbial communities
Scientific journals : Article
Life sciences : Environmental sciences & ecology
http://hdl.handle.net/10993/7775
The dynamic genetic repertoire of microbial communities
English
Wilmes, Paul mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Simmons, Sheri [> >]
Denef, Vincent J. [> >]
Banfield, Jillian F. [> >]
2009
FEMS Microbiology Reviews
Blackwell Publishing
33
1
109-132
Yes (verified by ORBilu)
0168-6445
Oxford
United Kingdom
[en] community genomics ; CRISPR ; genetic heterogeneity ; metagenomics ; population genomics ; virus-host dynamics
[en] Community genomic data have revealed multiple levels of variation between and within microbial consortia. This variation includes large-scale differences in gene content between ecosystems as well as within-population sequence heterogeneity. In the present review, we focus specifically on how fine-scale variation within microbial and viral populations is apparent from community genomic data. A major unresolved question is how much of the observed variation is due to neutral vs. adaptive processes. Limited experimental data hint that some of this fine-scale variation may be in part functionally relevant, whereas sequence-based and modeling analyses suggest that much of it may be neutral. While methods for interpreting population genomic data are still in their infancy, we discuss current interpretations of existing datasets in the light of evolutionary processes and models. Finally, we highlight the importance of virus-host dynamics in generating and shaping within-population diversity.
http://hdl.handle.net/10993/7775
10.1111/j.1574-6976.2008.00144.x

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