Reference : Time-resolved analysis of transcriptional events during SNAI1-triggered epithelial to...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/7447
Time-resolved analysis of transcriptional events during SNAI1-triggered epithelial to mesenchymal transition
English
Vetter, G. [> >]
Le Béchec, Antony [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Muller, J. [> >]
Muller, A. [> >]
Moes, Michèle mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Yatskou, M. [> >]
Al Tanoury, Z. [> >]
Poch, O. [> >]
Vallar, L. [> >]
Friederich, Evelyne mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
2009
Biochemical and Biophysical Research Communications
Academic Press
385
4
485-91
Yes (verified by ORBilu)
International
0006-291X
1090-2104
San Diego
CA
[en] The transcription regulator SNAI1 triggers a transcriptional program leading to epithelial to mesenchymal transition (EMT), providing epithelial cells with mesenchymal features and invasive properties during embryonic development and tumor progression. To identify early transcriptional changes occurring during SNAI1-induced EMT, we performed a time-resolved genome-scale study using human breast carcinoma cells conditionally expressing SNAI1. The approach we developed for microarray data analysis, allowed identifying three distinct EMT stages and the temporal classification of genes. Importantly, we identified unexpected, biphasic expression profiles of EMT-associated genes, supporting their pivotal role during this process. Finally, we established early EMT gene networks by identifying transcription factors and their potential targets which may orchestrate early events of EMT. Collectively, our work provides a framework for the identification and future systematic analysis of novel genes which contribute to SNAI1-triggered EMT.
http://hdl.handle.net/10993/7447
10.1016/j.bbrc.2009.05.025

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