Reference : Sleep apnea syndrome in Parkinson's disease. A case-control study in 49 patients.
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/10993/6918
Sleep apnea syndrome in Parkinson's disease. A case-control study in 49 patients.
English
Diederich, Nico mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Vaillant, Michel [> >]
Leischen, Mike [> >]
Mancuso, Giovanna mailto [University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Educational Measurement and Applied Cognitive Science (EMACS) >]
Golinval, Serge [> >]
Nati, Romain [> >]
Schlesser, Marc [> >]
2005
Movement disorders : official journal of the Movement Disorder Society
20
11
1413-8
Yes (verified by ORBilu)
International
0885-3185
United States
[en] Aged ; Analysis of Variance ; Body Mass Index ; Case-Control Studies ; Demography ; Humans ; Male ; Middle Aged ; Parkinson Disease/complications ; Polysomnography/methods ; Respiration ; Retrospective Studies ; Sleep Arousal Disorders/classification/etiology
[en] In PD, the impact of nocturnal respiration on sleep continuity and architecture has not been systematically investigated by polysomnography (PSG). We performed a case-control study with retrospective analysis of PSG data of 49 PD patients. After classifying the PD patients according to their apnea/hypopnea index (AHI), they were matched with 49 controls in terms of age, gender, and AHI. There were 21 PD patients (43%) who had sleep apnea syndrome (SAS), classified as mild (AHI, 5-15) in 10 patients, moderate (AHI, >15-30) in 4 patients, and severe (AHI, > 30) in 7 patients. PD patients had more deep sleep (P = 0.02) and more nocturnal awakenings (P < 0.001) than the controls. Their body mass index (BMI) was lower (P = 0.04), and they maintained a more favorable respiratory profile, with higher mean and minimal oxygen saturation values (P = 0.006 and 0.01, respectively). These differences were preserved when only considering PD patients with AHI > 15. PD patients had less obstructive sleep apneas (P = 0.035), independently from the factor AHI. Only the respiratory changes of 4 PD patients with BMI > 27 and AHI > 15 (8%) approximated those seen in the controls. At an early or middle stage of the disease, non-obese PD patients frequently have AHI values suggesting SAS, however, without the oxygen desaturation profile of SAS. Longitudinal studies of patients with such "abortive" SAS are warranted to establish if this finding reflects benign nocturnal respiratory muscle dyskinesia or constitutes a precursor sign of dysautonomia in PD.
http://hdl.handle.net/10993/6918
10.1002/mds.20624

There is no file associated with this reference.

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.