Reference : Progressive sleep 'destructuring' in Parkinson's disease. A polysomnographic study in...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/10993/6914
Progressive sleep 'destructuring' in Parkinson's disease. A polysomnographic study in 46 patients.
English
Diederich, Nico mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Vaillant, Michel [> >]
Mancuso, Giovanna mailto [University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Educational Measurement and Applied Cognitive Science (EMACS) >]
Lyen, Peter [> >]
Tiete, Jo [> >]
2005
Sleep medicine
6
4
313-8
Yes (verified by ORBilu)
International
1389-9457
Netherlands
[en] Adult ; Aged ; Disorders of Excessive Somnolence/diagnosis/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Parkinson Disease/epidemiology ; Polysomnography ; Retrospective Studies ; Severity of Illness Index ; Sleep Disorders/diagnosis/epidemiology ; Sleep, REM/physiology
[en] BACKGROUND: Sleep abnormalities in Parkinson's disease (PD) are frequent, but it is unknown whether or not there is progressive loss of physiological sleep architecture or what the causes could be. METHODS: Retrospective review of medical records and polysomnographic data from 46 non-demented PD patients. RESULTS: Sleep latency was correlated with disease duration (F1,44=4.87, P=0.03). Total sleep time (F1,44=8.54, P=0.005), deep sleep time (F1,44=4.06, P=0.05), REM sleep time (F1,44=9.15, P=0.004) and sleep efficiency (SE) (F1,44=10.20, P=0.003) were inversely correlated with disease duration. The same sleep parameters were independent from the degree of motor impairment, dosage of the dopaminergic medications, and age. Subjective sleep complaints could only partially predict abnormalities in polysomnographic (PSG) studies. CONCLUSION: In PD nocturnal sleep 'destructuring' is linked to disease duration and evolves independently from other major disease parameters.
http://hdl.handle.net/10993/6914

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