Reference : The actin cytoskeleton as a therapeutic target: state of the art and future directions.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/6276
The actin cytoskeleton as a therapeutic target: state of the art and future directions.
English
Giganti, Adeline [> >]
Friederich, Evelyne mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
2003
Progress in cell cycle research
5
511-25
Yes (verified by ORBilu)
International
1087-2957
United States
[en] Actin Cytoskeleton/drug effects/metabolism ; Actins/drug effects/metabolism ; Animals ; Antineoplastic Agents/pharmacology ; Cell Division/drug effects/physiology ; Cell Movement/drug effects/physiology ; Cytoskeleton/drug effects/metabolism ; Drug Evaluation, Preclinical/trends ; Forecasting ; Humans ; Neoplasms/drug therapy/metabolism/physiopathology
[en] Dynamic processes such as cell migration and division depend on the actin cytoskeleton, a dense meshwork of protein polymers capable of undergoing rapid cycles of assembly and disassembly, under the control of a large number of actin-associated proteins. In cancer cells, structural and functional perturbations of the actin cytoskeleton correlate with higher proliferation rates and uncontrolled movement. Therefore, small molecules that act on the actin cytoskeleton of tumour cells and thus inhibit cell division and movement, may be of high therapeutic value. The dynamic properties of the actin cytoskeleton and the mechanism of action of actin-targeting drugs will be described.
http://hdl.handle.net/10993/6276

There is no file associated with this reference.

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.