Reference : Genotypic and antigenic characterization of hemagglutinin proteins of African measles...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/4929
Genotypic and antigenic characterization of hemagglutinin proteins of African measles virus isolates
English
Truong, A. T. [Department of Virology, University College Hospital Ibadan, Ibadan, Nigeria]
Kreis, Stephanie mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Ammerlaan, W. [LVO, Rijksinstituut V. Volksgezondheid M., Bilthoven, Netherlands]
Hartter, H. K. [> >]
Adu, F. [> >]
Omilabu, S. A. [> >]
Oyefolu, A. O. [> >]
Berbers, G. A. M. [> >]
Muller, Claude [CRP-Santé Luxembourg]
1999
Virus Research
Elsevier Science
62
1
89-95
Yes (verified by ORBilu)
0168-1702
Amsterdam
The Netherlands
[en] Africa; Hemagglutinin; Measles virus; Monoclonal antibodies; Sequence
[en] A comprehensive phylogenetic study based on the hemagglutinin (H) protein of all known African measles virus (MV) isolates is presented. The study includes 64 new H gene sequences from Ghana, Nigeria and South Africa as well as viruses from Zambia and The Gambia for which only incomplete sequencing data were available and that have previously not been genotyped. The results provide further support to the tentative assignment of the Nigerian and Ghanaian viruses to a new genotype B3 within clade B. A distinct geographic distribution pattern emerged with clade B viruses circulating exclusively in African countries north of the equator. All MV strains from southern Africa grouped in clades A and D with the majority of viruses belonging to genotype D4. The viruses considerably differed by their sensitivity to neutralization by monoclonal antibodies (mAb), but three selected antibodies were sufficient to distinguish between African MVs representing four different genotypes. Copyright (C) 1999 Elsevier Science B.V.
http://hdl.handle.net/10993/4929
10.1016/S0168-1702(99)00072-6
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032797481&partnerID=40&md5=a0b7b169a0a7f030e8256fe79a1424f9
cited By (since 1996)38
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