Reference : IL-24: a classic cytokine and/or a potential cure for cancer?
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Systems Biomedicine
http://hdl.handle.net/10993/4920
IL-24: a classic cytokine and/or a potential cure for cancer?
English
Kreis, Stephanie mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Philippidou, Demetra mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Margue, Christiane [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Behrmann, Iris mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
10-May-2008
Journal of Cellular & Molecular Medicine
Blackwell Publishing
12
6A
2505-2510
Yes
International
1582-1838
[en] IL-24 ; cytokine ; melanoma ; cancer treatment
[en] IL-24, a member of the IL-10 family of cytokines, is produced by monocytes and Th2 cells. Interestingly, immune cells do not appear to express specific IL-24 receptor chains (IL-20R1/IL-20R2 and IL-22R/IL-20R2), it is therefore unlikely that IL-24 has classical immune-modulating properties. Skin, on the other hand, seems to represent a major target tissue for IL-24 and related cytokines such as IL-19, -20, and -22. However, the initial interest in IL-24 did not arise from its physiological signalling properties through its cognate receptors but rather because of its tentative ability to selectively kill different cancer cells. In an attempt to further investigate the signalling events underlying the IL-24-induced cancer cell death, we found that melanoma cell lines did not react in the expected and previously described way. Using several different forms and delivery modes of IL-24, we were unable to detect any apoptosis-inducing properties of this cytokine in melanoma cells. In the present "Point of view" we will briefly summarise these findings and put them in context of published reports stating that IL-24 might be a long sought after treatment for several types of cancer.
Life Science Research Unit-University of Luxembourg
University of Luxembourg - UL
Researchers
http://hdl.handle.net/10993/4920
10.1111/j.1582-4934.2008.00372.x

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