Reference : Modeling RNA loops using sequence homology and geometric constraints.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/483
Modeling RNA loops using sequence homology and geometric constraints.
English
Schudoma, Christian [> >]
May, Patrick mailto [Max Planck Institute for Molecular Plant Physiology > Bioinformatics]
Walther, Dirk [> >]
2010
Bioinformatics (Oxford, England)
26
13
1671-2
Yes (verified by ORBilu)
International
1367-4803
1367-4811
England
[en] Models, Chemical ; Nucleic Acid Conformation ; RNA/chemistry ; Sequence Homology, Nucleic Acid ; Software
[en] SUMMARY: RNA loop regions are essential structural elements of RNA molecules influencing both their structural and functional properties. We developed RLooM, a web application for homology-based modeling of RNA loops utilizing template structures extracted from the PDB. RLooM allows the insertion and replacement of loop structures of a desired sequence into an existing RNA structure. Furthermore, a comprehensive database of loops in RNA structures can be accessed through the web interface. AVAILABILITY AND IMPLEMENTATION: The application was implemented in Python, MySQL and Apache. A web interface to the database and loop modeling application is freely available at http://rloom.mpimp-golm.mpg.de CONTACT: schudoma@mpimp-golm.mpg.de; may@mpimp-golm.mpg.de; walther@mpimp-golm.mpg.de
http://hdl.handle.net/10993/483
10.1093/bioinformatics/btq236
http://bioinformatics.oxfordjournals.org/content/26/13/1671.long

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