Reference : Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Systems Biomedicine
http://hdl.handle.net/10993/40624
Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells
English
Ullmann, Pit mailto [Life Sciences Research Unit, University of Luxembourg > Molecular Disease Mechanisms Group]
Nurmik, Martin mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Begaj, Rubens mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Haan, Serge mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Letellier, Elisabeth mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
1-Jun-2019
Cells
Multidisciplinary Digital Publishing Institute (MDPI)
8
6
Yes
International
2073-4409
Basel
Switzerland
[lb] cancer stem cell ; colorectal cancer ; hypoxia
[en] metabolic reprogramming ; miR-210 ; stemness ; tumor-initiating cell
[en] Colorectal cancer (CRC), the second most common cause of cancer mortality in theWestern
world, is a highly heterogeneous disease that is driven by a rare subpopulation of tumorigenic cells,
known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Over the past few years, a plethora
of di erent approaches, aimed at identifying and eradicating these self-renewing TICs, have been
described. A focus on the metabolic and bioenergetic di erences between TICs and less aggressive
di erentiated cancer cells has thereby emerged as a promising strategy to specifically target the
tumorigenic cell compartment. Extrinsic factors, such as nutrient availability or tumor hypoxia,
are known to influence the metabolic state of TICs. In this review, we aim to summarize the current
knowledge on environmental stress factors and how they a ect the metabolism of TICs, with a special
focus on microRNA (miRNA)- and hypoxia-induced e ects on colon TICs.
University of Luxembourg
Fondation Cancer ; Fondation du PĂ©lican de Mie
Researchers ; Others
http://hdl.handle.net/10993/40624
10.3390/cells8060528
FnR ; FNR7855578 > Pit Ullmann > > Identification and functional investigation of hypoxia-induced miRNAs in colon cancer stem cells > 01/03/2014 > 31/05/2017 > 2014

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