Reference : Extensive transmission of microbes along the gastrointestinal tract
Scientific journals : Article
Life sciences : Microbiology
http://hdl.handle.net/10993/39708
Extensive transmission of microbes along the gastrointestinal tract
English
Schmidt, Thomas []
Hayward, Matthew []
Coelho, Luis []
Li, Simone []
Costea, Paul []
Voigt, Anita []
Wirbel, Jakob []
Maistrenko, Oleksandr []
Alves, Renato []
Bergsten, Emma []
de Beaufort, Carine [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Sobhani, Irdaj []
Heintz, Anna [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Sunagawa, Shinichi []
Zeller, Georg []
Wilmes, Paul mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Bork, Peer []
Feb-2019
eLife
eLife Sciences Publications
Yes
International
2050-084X
Cambridge
United Kingdom
[en] The gastrointestinal tract is abundantly colonized by microbes, yet the translocation of oral species to the intestine is considered a rare aberrant event, and a hallmark of disease. By studying salivary and fecal microbial strain populations of 310 species in 470 individuals from five countries, we found that transmission to, and subsequent colonization of, the large intestine by oral microbes is common and extensive among healthy individuals. We found evidence for a vast majority of oral species to be transferable, with increased levels of transmission in colorectal cancer and rheumatoid arthritis patients and, more generally, for species described as opportunistic pathogens. This establishes the oral cavity as an endogenous reservoir for gut microbial strains, and oral-fecal transmission as an important process that shapes the gastrointestinal microbiome in health and disease.
http://hdl.handle.net/10993/39708
10.7554/eLife.42693
FnR ; FNR10404093 > Paul Wilmes > microCancer > Non-invasive microbiome-derived multi-omic biomarkers for early-stage colorectal cancer detection > 01/01/2016 > 30/04/2019 > 2015

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