Reference : Engineering Solutions for Representative Models of the Gastrointestinal Human-Microbe...
Scientific journals : Article
Engineering, computing & technology : Multidisciplinary, general & others
http://hdl.handle.net/10993/38652
Engineering Solutions for Representative Models of the Gastrointestinal Human-Microbe Interface
English
Mac Giolla Eain, Marc [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Baginska, Joanna [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Greenhalgh, Kacy mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Fritz, Joëlle [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Zenhausern, Frederic []
Wilmes, Paul mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
2017
Engineering
Elsevier
Yes
International
2095-8099
United Kingdom
[en] Microbiome ; Microfluidics ; Organ-on-a-chip ; HuMiX
[en] Host-microbe interactions at the gastrointestinal interface have emerged as a key component in the governance of human health and disease. Advances in micro-physiological systems are providing researchers with unprecedented access and insights into this complex relationship. These systems combine the benefits of microengineering, microfluidics, and cell culture in a bid to recreate the environmental conditions prevalent in the human gut. Here we present the human-microbial cross talk (HuMiX) platform, one such system that leverages this multidisciplinary approach to provide a representative in vitro model of the human gastrointestinal interface. HuMiX presents a novel and robust means to study the molecular interactions at the host-microbe interface. We summarize our proof-of-concept results obtained using the platform and highlight its potential to greatly enhance our understanding of host-microbe interactions with a potential to greatly impact the pharmaceutical, food, nutrition, and healthcare industries in the future. A number of key questions and challenges facing these technologies are also discussed.
Fonds National de la Recherche - FnR
http://hdl.handle.net/10993/38652
10.1016/J.ENG.2017.01.011
FnR ; FNR11014639 > Paul Wilmes > HuMiX2.0 > A microfluidics-based drug discovery platform emulating the human microbiome on chip > 01/01/2016 > 30/04/2017 > 2015

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
GiollaEain(2017)Engineering.pdfPublisher postprint1.77 MBView/Open

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.