Reference : Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's ...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/38077
Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease
English
Pavlou, Maria Angeliki mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Lázaro, Diana []
Outeiro, Tiago []
Dec-2017
Experimental Neurology
Elsevier
Yes (verified by ORBilu)
International
0014-4886
1090-2430
Atlanta
FL
[en] Neurodegenerative diseases are highly debilitating conditions characterised primarily by progressive neuronal loss and impairment of the nervous system. Parkinson's disease (PD) is one of the most common of these disorders, affecting 1-2% of the population above the age of 65. Although the underlying mechanisms of PD have been extensively studied, we still lack a full understanding of the molecular underpinnings of the disease. Thus, the in vitro and in vivo models currently used are able to only partially recapitulate the typical phenotypes of the disease. Here, we review various cell culture models currently used to study the molecular basis of PD, with a focus on alpha-synuclein-associated molecular pathologies. We also discuss how different cell models may constitute powerful tools for high-throughput screening of molecules capable of modulating alpha-synuclein toxicity.
http://hdl.handle.net/10993/38077
10.1016/j.expneurol.2017.05.007

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