Reference : The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Ear...
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
Human health sciences : Multidisciplinary, general & others
Systems Biomedicine
http://hdl.handle.net/10993/37739
The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis
English
Hipp Epouse D'amico, Géraldine mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Vaillant, Michel mailto []
Diederich, Nico J. mailto []
Roomp, Kirsten mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Satagopam, Venkata mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Banda, Peter mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Sandt, Estelle mailto []
Mommaerts, Kathleen mailto []
Schmitz, Sabine mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Longhino, Laura mailto []
Schweicher, Alexandra mailto []
Hanff, Anne-Marie mailto []
Nicolai, Béatrice mailto []
Kolber, Pierre Luc mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Reiter, Dorothea mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Pavelka, Lukas mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Binck, Sylvia mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Pauly, Claire mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Geffers, Lars mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Betsou, Fay mailto []
Gantenbein, Manon mailto []
Klucken, Jochen mailto []
Gasser, Thomas mailto []
Hu, Michele mailto []
Balling, Rudi mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Krüger, Rejko mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
29-Oct-2018
Frontiers in Aging Neuroscience
Frontiers Media S.A.
10
326
Yes (verified by ORBilu)
International
1663-4365
1663-4365
Lausanne
Switzerland
[en] parkinsonism ; cohort ; longitudinal ; stratification ; deep phenotyping
[en] While genetic advances have successfully defined part of the complexity in Parkinson’s disease (PD), the clinical characterization of phenotypes remains challenging. Therapeutic trials and cohort studies typically include patients with earlier disease stages and exclude comorbidities, thus ignoring a substantial part of the real-world PD population. To account for these limitations, we implemented the Luxembourg PD study as a comprehensive clinical, molecular and device-based approach including patients with typical PD and atypical parkinsonism, irrespective of their disease stage, age, comorbidities, or linguistic background. To provide a large, longitudinally followed, and deeply phenotyped set of patients and controls for clinical and fundamental research on PD, we implemented an open-source digital platform that can be harmonized with international PD cohort studies. Our interests also reflect Luxembourg-specific areas of PD research, including vision, gait, and cognition. This effort is flanked by comprehensive biosampling efforts assuring high quality and sustained availability of body liquids and tissue biopsies. We provide evidence for the feasibility of such a cohort program with deep phenotyping and high quality biosampling on parkinsonism in an environment with structural specificities and alert the international research community to our willingness to collaborate with other centers. The combination of advanced clinical phenotyping approaches including device-based assessment will create a comprehensive assessment of the disease and its variants, its interaction with comorbidities and its progression. We envision the Luxembourg Parkinson’s study as an important research platform for defining early diagnosis and progression markers that translate into stratified treatment approaches.
Luxembourg Centre for Systems Biomedicine (LCSB)
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/10993/37739
10.3389/fnagi.2018.00326
https://www.frontiersin.org/articles/10.3389/fnagi.2018.00326/full
FnR ; NCER13/BM/11264123

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