Reference : Tightly Connected Water Wires Facilitate Fast Proton Uptake at The Proton Entrance of...
Scientific journals : Other
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/10993/3764
Tightly Connected Water Wires Facilitate Fast Proton Uptake at The Proton Entrance of Proton Pumping Proteins
English
Gu, Wei mailto []
Helms, Volkhard [> >]
2009
Journal of the American Chemical Society
American Chemical Society
131
6
2080-+
Yes (verified by ORBilu)
International
0002-7863
1520-5126
Washington
DC
[en] Tightly connected water wires (TCW) exist in systems with nonconfined water like the solvated membrane proton pump system. The TCWs that connect to the negatively charged proton entrance facilitate the fast proton uptake of the proton pump. They function as a direct proton bridge or/and stabilizer of protons within the Coulomb cage of the proton entrance. Negatively charged residue(s) at the proton entrance induce a large population of long TCWs. Additional negatively charged residues increase the population of such long TCWs and, thus, raise the possibility to capture proton from the solution.
http://hdl.handle.net/10993/3764
10.1021/ja809301w

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