Reference : Recon3D enables a three-dimensional view of gene variation in human metabolism.
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/35687
Recon3D enables a three-dimensional view of gene variation in human metabolism.
English
Brunk, Elizabeth [> >]
Sahoo, Swagatika [> >]
Zielinski, Daniel C. [> >]
Altunkaya, Ali [> >]
Drager, Andreas [> >]
Mih, Nathan [> >]
Gatto, Francesco [> >]
Nilsson, Avlant [> >]
Preciat Gonzalez, German Andres mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Aurich, Maike Kathrin [> >]
Prlic, Andreas [> >]
Sastry, Anand [> >]
Danielsdottir, Anna D. [> >]
Heinken, Almut Katrin mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Noronha, Alberto mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Rose, Peter W. [> >]
Burley, Stephen K. [> >]
Fleming, Ronan MT mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Nielsen, Jens [> >]
Thiele, Ines mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Palsson, Bernhard O. [> >]
2018
Nature biotechnology
36
3
272-281
Yes (verified by ORBilu)
International
1087-0156
1546-1696
United States
[en] Genome-scale network reconstructions have helped uncover the molecular basis of metabolism. Here we present Recon3D, a computational resource that includes three-dimensional (3D) metabolite and protein structure data and enables integrated analyses of metabolic functions in humans. We use Recon3D to functionally characterize mutations associated with disease, and identify metabolic response signatures that are caused by exposure to certain drugs. Recon3D represents the most comprehensive human metabolic network model to date, accounting for 3,288 open reading frames (representing 17% of functionally annotated human genes), 13,543 metabolic reactions involving 4,140 unique metabolites, and 12,890 protein structures. These data provide a unique resource for investigating molecular mechanisms of human metabolism. Recon3D is available at http://vmh.life.
http://hdl.handle.net/10993/35687

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