Reference : Natural variation of chronological aging in the Saccharomyces cerevisiae species reve...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Life sciences : Genetics & genetic processes
Systems Biomedicine
http://hdl.handle.net/10993/35231
Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control
English
Jung, Paul mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Zhang, Zhi mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Paczia, Nicole mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Jäger, Christian mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Ignac, Tomasz []
May, Patrick mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Linster, Carole mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
12-Mar-2018
npj Aging and Mechanisms of Disease
4
3
Yes
International
2056-3973
2056-3973
[en] yeast ; aging ; natural variation ; RIM15 ; SER1 ; QTL
[en] Aging is a complex trait of broad scientific interest, especially because of its intrinsic link with common human diseases. Pioneering work on aging-related mechanisms has been made in Saccharomyces cerevisiae, mainly through the use of deletion collections isogenic to the S288c reference strain. In this study, using a recently published high-throughput approach, we quantified chronological life span (CLS) within a collection of 58 natural strains across seven different conditions. We observed a broad aging variability suggesting the implication of diverse genetic and environmental factors in chronological aging control. Two major Quantitative Trait Loci (QTLs) were identified within a biparental population obtained by crossing two natural isolates with contrasting aging behavior. Detection of these QTLs was dependent upon the nature and concentration of the carbon sources available for growth. In the first QTL, the RIM15 gene was identified as major regulator of aging under low glucose condition, lending further support to the importance of nutrient-sensing pathways in longevity control under calorie restriction. In the second QTL, we could show that the SER1 gene, encoding a conserved aminotransferase of the serine synthesis pathway not previously linked to aging, is causally associated with CLS regulation, especially under high glucose condition. These findings hint toward a new mechanism of life span control involving a trade-off between serine synthesis and aging, most likely through modulation of acetate and trehalose metabolism. More generally it shows that genetic linkage studies across natural strains represent a promising strategy to further unravel the molecular basis of aging.
Luxembourg Centre for Systems Biomedicine (LCSB): Enzymology & Metabolism (Linster Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) ; University of Luxembourg: High Performance Computing - ULHPC
FNR (INTER/BMBF/13/04), e:Med BMBF ; FNR (MitoPD) ; plan Technologies de la Santé ; FNR (NCER-PD)
Researchers
http://hdl.handle.net/10993/35231
10.1038/s41514-018-0022-6
https://www.nature.com/articles/s41514-018-0022-6
FnR ; FNR11339953 > Nicole Paczia > COMET > Completing the metabolic map around the oncometabolite D-2-hydroxyglutarate > 01/11/2016 > 31/03/2019 > 2016

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