Reference : Reply: No evidence for rare TRAP1 mutations influencing the risk of idiopathic Parkin...
Scientific journals : Article
Life sciences : Genetics & genetic processes
Human health sciences : Neurology
Systems Biomedicine
http://hdl.handle.net/10993/34207
Reply: No evidence for rare TRAP1 mutations influencing the risk of idiopathic Parkinson’s disease
English
Fitzgerald, Julia C. []
Zimprich, Alexander []
Bobbili, Dheeraj Reddy mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Sharma, Manu []
May, Patrick mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Krüger, Rejko mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
24-Jan-2018
Brain : A Journal of Neurology
Oxford University Press
Yes (verified by ORBilu)
International
0006-8950
1460-2156
Oxford
United Kingdom
[en] Parkinson's disease ; TRAP1 ; Mutations
[en] Sir,

In their letter in this issue, Gaare and colleagues (2018) state that TRAP1 may not be a Parkinson’s disease gene because of lack of genetic association. In response, we welcome their data analyses and we welcome any further genetic analyses of TRAP1 variants in additional Parkinson’s disease genetic datasets, including the reanalysis of open access datasets such as the Parkinson’s Progressive Markers Initiative (PPMI). Our point of view is that TRAP1 is an interesting effector protein that our study unequivocally showed is relevant to Parkinson’s disease signaling in the context of mitochondrial regulation. Furthermore, the overall contribution of TRAP1 genetic variants to Parkinson’s disease was not the focus of our recent paper in Brain (Fitzgerald et al., 2017).
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) ; University of Luxembourg: High Performance Computing - ULHPC
Researchers ; Professionals
http://hdl.handle.net/10993/34207
10.1093/brain/awx380
https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awx380/4823739

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