Reference : Unilateral Holmes tremor, clearly responsive to cerebrospinal fluid release, in a pat...
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/34067
Unilateral Holmes tremor, clearly responsive to cerebrospinal fluid release, in a patient with an ischemic midbrain lesion and associated chronic hydrocephalic ventricle enlargement. Case report.
English
Hertel, Frank mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Zuchner, Mark [> >]
Decker, Christian [> >]
Erken, Edward [> >]
Libri, Stefani [> >]
Schmitt, Marion [> >]
Bettag, Martin [> >]
2006
Journal of neurosurgery
104
3
448-51
Yes (verified by ORBilu)
0022-3085
United States
[en] Brain Ischemia/complications ; Cerebral Ventricles/pathology ; Electrophysiology ; Humans ; Hydrocephalus/complications/etiology/therapy ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Recurrence ; Tomography, Emission-Computed, Single-Photon ; Treatment Outcome ; Tremor/etiology ; Ventriculoperitoneal Shunt
[en] The authors describe a 58-year-old man with sudden onset of a unilateral tremor caused by a midbrain lesion that affected the substantia nigra and the cerebellothalamic pathway. There were also clinical and neuroimaging signs of a communicating chronic hydrocephalus. The patient was severely handicapped by this tremor, which was a typical Holmes tremor with rest, posture, and intention components. Parkinson disease or multiple-system atrophy as causes for the tremor could be ruled out by DaTSCAN and 123I iodobenzamide and single-photon emission computerized tomography (SPECT), respectively. The tremor was completely supressed by temporary and permanent cerebrospinal fluid release after ventriculoperitoneal shunt placement, without any additional medication, for a period of 6 months. Afterward, the tremor returned, and the patient had to be treated by a stereotactic electrode implantation in the contralateral ventralis intermedius nucleus, which led to complete tremor suppression during the 1.5-year follow-up period. In this case report, the authors present the clinical description and the electrophysiological, SPECT, and magnetic resonance imaging data of a rare combination of symptoms and their surgical treatment.
http://hdl.handle.net/10993/34067
10.3171/jns.2006.104.3.448

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