Reference : Gene regulatory network analysis supports inflammation as a key neurodegeneration pro...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/3323
Gene regulatory network analysis supports inflammation as a key neurodegeneration process in prion disease.
English
Crespo, Isaac mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Rump, Kirsten mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Jurkowski, Wiktor mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Kitano, H. [> >]
del Sol Mesa, Antonio mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
2012
BMC Systems Biology
BioMed Central
6
132
Yes (verified by ORBilu)
1752-0509
[en] The activation of immune cells in the brain is believed to be one of the earliest events in prion disease development, where misfolded PrionSc protein deposits are thought to act as irritants leading to a series of events that culminate in neuronal cell dysfunction and death. The role of these events in prion disease though is still a matter of debate. To elucidate the mechanisms leading from abnormal protein deposition to neuronal injury, we have performed a detailed network analysis of genes differentially expressed in several mouse prion models
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Computational Biology (Del Sol Group)
http://hdl.handle.net/10993/3323
10.1186/1752-0509-6-132

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