Reference : Molecular mechanisms of kinase inhibitor resistance in melanoma
Dissertations and theses : Doctoral thesis
Life sciences : Biochemistry, biophysics & molecular biology
Systems Biomedicine
http://hdl.handle.net/10993/32420
Molecular mechanisms of kinase inhibitor resistance in melanoma
English
Cesi, Giulia mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
5-Sep-2017
University of Luxembourg, ​​Luxembourg
Docteur en Biologie
163
Kreis, Stephanie mailto
Haan, Serge mailto
Janji, Bassam mailto
Kulms, Dagmar mailto
Thorsen, Frits mailto
[en] melanoma ; drug resistance ; kinase inhibitors ; extracellular vesicles ; microRNAs ; metabolism
[en] In my thesis, I elucidated several aspects of melanoma biology, all related to the influence of
targeted therapies in both responding and resistant melanoma cells. To better understand the MAPK signalling pathway, the impact of BRAF inhibitors on metabolic alterations as well as the connection between BRAF inhibitors and the onset of drug resistance was investigated. This introduction is focused on four topics: i) melanoma, ii) cancer metabolism, iii) miRNAs and iv) extracellular vesicles. First, melanoma biology including incidence rates, etiology, canonical and altered signalling pathways, therapies and resistance mechanisms will be introduced. The second part of the introduction will concentrate on metabolic alterations in the context of cancer and their implication on proliferation and survival. Thirdly, miRNAs and extracellular vesicles will be illustrated providing insights into their role in cancer development and especially drug resistance
University of Luxembourg - UL
Researchers
http://hdl.handle.net/10993/32420

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
PhD thesis Giulia Cesi 5-9-17.pdfAuthor preprint17.56 MBView/Open

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.