Reference : Transcriptional variations in the wider peritumoral tissue environment of pancreatic ...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/32313
Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer
English
Bauer, Andrea S. [German Cancer Research Centre > Division of Functional Genome Analysis]
Nazarov, Petr V. [Luxembourg Institute of Health > Genomics and Proteomics Research Unit]
Giese, Nathalia A. [University Hospital Heidelberg > Department of General Surgery]
Beghelli, Stefania [Universita di Verona > Department of Pathology and Diagnostics]
Heller, Anette [University Hospital Heidelberg > Department of General Surgery]
Greenhalf, William [Pancreas Biomedical Research Unit and the Liverpool Experimental Cancer Medicine Centre > National Institute for Health Research]
Costello, Eithne [National Institute for Health Research > Pancreas Biomedical Research Unit and the Liverpool Experimental Cancer Medicine Centre]
Muller, Arnaud [Luxembourg Institute of Health - LIH > Genomics and Proteomics Research Unit]
Bier, Melanie [German Cancer Research Centre > Division of Functional Genome Analysis]
Strobel, Oliver [University Hospital Heidelberg > Department of General Surgery]
Hackert, Thilo [University Hospital Heidelberg > Department of General Surgery]
Vallar, Laurent [Luxembourg Institute of Health > Genomics and Proteomics Research Unit]
Scarpa, Aldo [Universita di Verona > Department of Pathology and Diagnostics]
Büchler, Markus W. [University Hospital Heidelberg > Department of General Surgery]
Neoptolemos, John P. [National Institute for Health Research > Pancreas Biomedical Research Unit and the Liverpool Experimental Cancer Medicine Centre]
Kreis, Stephanie mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Hoheisel, Jorg D. [German Cancer Research Centre > Division of Functional Genome Analysis]
1-Mar-2018
International Journal of Cancer = Journal International du Cancer
Wiley Liss, Inc.
142
5
1010–1021
Yes
International
1010-1021
New York
NY
[en] disease prognosis ; survival ; transcript variations ; peritumoral tissue ; pancreatic cancer
[en] Transcriptional profiling was performed on 452 RNA preparations isolated from various types of pancreatic tissue from tumour patients and healthy donors, with a particular focus on peritumoral samples. Pancreatic ductal adenocarcinomas (PDAC) and cystic tumours were most different in these non-tumorous tissues surrounding them, whereas the actual tumours exhibited rather similar transcript patterns. The environment of cystic tumours was transcriptionally nearly identical to normal pancreas tissue. In contrast, the tissue around PDAC behaved a lot like the tumour, indicating some kind of field defect, while showing far less molecular resemblance to both chronic pancreatitis and healthy tissue. This suggests that the major pathogenic difference between cystic and ductal tumours may be due to their cellular environment rather than the few variations between the tumours. Lack of correlation between DNA methylation and transcript levels makes it unlikely that the observed field defect in the peritumoral tissue of PDAC is controlled to a large extent by such epigenetic regulation. Functionally, a strikingly large number of autophagy-related transcripts was changed in both PDAC and its peritumoral tissue, but not in other pancreatic tumours. A transcription signature of 15 autophagy-related genes was established that permits a prognosis of survival with high accuracy and indicates the role of autophagy in tumour biology.
Researchers
http://hdl.handle.net/10993/32313
10.1002/ijc.31087

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