Reference : Sequence analysis of the nucleocapsid gene of measles virus isolates from South Afric...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/4986
Sequence analysis of the nucleocapsid gene of measles virus isolates from South Africa identifies a new genotype
English
Kreis, Stephanie mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Vardas, E. [> >]
Whistler, T. [> >]
1997
Journal of General Virology (The)
Society for General Microbiology
78
7
1581-1587
Yes (verified by ORBilu)
International
0022-1317
1465-2099
London
United Kingdom
[en] amino acid substitution; article; carboxy terminal sequence; genotype; measles virus; nonhuman; phylogeny; polymerase chain reaction; priority journal; rna sequence; south africa; viral genetics; virus nucleocapsid ; Amino Acid Sequence; Base Sequence; Cell Line; DNA ; Viral; Genotype; Humans; Measles virus; Molecular Sequence Data; Nucleocapsid; Phylogeny; Sequence Analysis ; DNA; Sequence Homology ; Amino Acid; South Africa ; Measles virus
[en] Sequence analysis was performed on 20 measles virus (MV) isolates from South Africa, five of which were obtained between 1986 and 1989 and 15 isolates collected during the 1994/95 measles season. A 590 bp fragment of the carboxyl terminus of the nucleocapsid (N) was amplified by PCR and subjected to sequence and phylogenetic analysis. Comparison of the South African MV strains with those previously described revealed that at least two distinct groups of wild-type (wt) MV exist, one of which has been circulating since 1986. The major genotype (I) was represented by the more recent isolates which showed three characteristic amino acid substitutions. Furthermore, three vaccine-like viruses with sequences very similar to the Edmonston wt strain were identified. Phylogenetic analysis of 100 MV strains allowed the assignment of new definitions for MV genotypes and subgroups. Employing these definitions, the majority of South African isolates analysed here formed a new genotype.
Researchers
http://hdl.handle.net/10993/4986
also: http://hdl.handle.net/10993/32302
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030846363&partnerID=40&md5=10bf79fc76615ebba2443e1f7bc3c953
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