Reference : Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and s...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/32238
Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review.
English
Mandenius, Carl-Fredrik [> >]
Steel, Daniella [> >]
Noor, Fozia mailto [Saarland University > Biochemical Engineering]
Meyer, Thomas [> >]
Heinzle, Elmar [> >]
Asp, Julia [> >]
Arain, Sarina [> >]
Kraushaar, Udo [> >]
Bremer, Susanne [> >]
Class, Reiner [> >]
Sartipy, Peter [> >]
2011
Journal of applied toxicology : JAT
31
3
191-205
Yes (verified by ORBilu)
International
0260-437X
1099-1263
England
[en] Animal Testing Alternatives ; Animals ; Cell Differentiation ; Cell Line, Transformed ; Drug Evaluation, Preclinical ; Drug-Related Side Effects and Adverse Reactions/classification ; Heart Diseases/chemically induced/pathology/physiopathology ; Humans ; Myocytes, Cardiac/drug effects/metabolism/pathology ; Oxygen Consumption ; Pluripotent Stem Cells/cytology/drug effects ; Xenobiotics/toxicity
[en] In this article, recent progress in cardiotoxicity testing based on the use of immortalized cell lines or human embryonic stem cell (hESC) derived cardiomyocytes in combination with state-of-the-art bioanalytical methods and sensors is reviewed. The focus is on hESC-derived cells and their refinement into competent testing cells, but the access and utility of other relevant cell types are also discussed. Recent developments in sensor techniques and bioanalytical approaches for measuring critical cardiotoxicity parameters are highlighted, together with aspects of data evaluation and validation. Finally, recommendations for further research are given.
http://hdl.handle.net/10993/32238
10.1002/jat.1663
Copyright (c) 2011 John Wiley & Sons, Ltd.

There is no file associated with this reference.

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.