Reference : Sources and Functions of Extracellular Small RNAs in Human Circulation.
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
Systems Biomedicine
http://hdl.handle.net/10993/27977
Sources and Functions of Extracellular Small RNAs in Human Circulation.
English
Fritz, Joëlle mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Heintz-Buschart, Anna mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Ghosal, Anubrata [Massachusetts Institute of Technology - MIT > Department of Biology]
Wampach, Linda mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Etheridge, Alton [Pacific Northwest Diabetes Research Institute]
Galas, David [Pacific Northwest Diabetes Research Institute > > > ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine]
Wilmes, Paul mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
2016
Annual review of nutrition
Yes (verified by ORBilu)
International
0199-9885
1545-4312
[en] blood, vesicle, gene regulation, microRNA, microorganisms, plant
[en] Various biotypes of endogenous small RNAs (sRNAs) have been detected in human circulation, including microRNAs, transfer RNAs, ribosomal RNA, and yRNA fragments. These extracellular sRNAs (ex-sRNAs) are packaged and secreted by many different cell types. Ex-sRNAs exhibit differences in abundance in several disease states and have, therefore, been proposed for use as effective biomarkers. Furthermore, exosome-borne ex-sRNAs have been reported to elicit physiological responses in acceptor cells. Exogenous ex-sRNAs derived from diet (most prominently from plants) and microorganisms have also been reported in human blood. Essential issues that remain to be conclusively addressed concern the (a) presence and sources of exogenous ex-sRNAs in human bodily fluids, (b) detection and measurement of ex-sRNAs in human circulation, (c) selectivity of ex-sRNA export and import, (d) sensitivity and specificity of ex-sRNA delivery to cellular targets, and (e) cell-, tissue-, organ-, and organism-wide impacts of ex-sRNA-mediated cell-to-cell communication. We survey the present state of knowledge of most of these issues in this review. Expected final online publication date for the Annual Review of Nutrition Volume 36 is July 17, 2016. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.
Fonds National de la Recherche - FnR ; US National Institutes of Health
Researchers
http://hdl.handle.net/10993/27977
10.1146/annurev-nutr-071715-050711
FnR ; FNR8066232 > Joelle Fritz > BEaR (for Bacterial ExtrAcellular RNA) > Host-microbes interactions via bacterial extracellular small RNAs > 01/04/2015 > 31/08/2017 > 2014

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