Reference : Cognitive, emotional and psychosocial functioning of girls treated with pharmacologic...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/10993/27956
Cognitive, emotional and psychosocial functioning of girls treated with pharmacological puberty blockage for idiopathic central precocious puberty
English
Wojniusz, S [Oslo University Hospital, Norway > Department of Psychosomatic Medicine]
Callens, N [Oslo and Akershus University College of Applied Sciences, Norway > Department of Physiotherapy]
Sütterlin, S [Lillehammer University College, Norway > Section of Psychology]
Andersson, S [Oslo University Hospital, Norway > Department of Psychosomatic Medicine]
DeSchepper, J [Ghent University Hospital and Ghent University, Belgium > Department of Pediatrics]
Giess, I [Brussels University Hospital, Belgium > Department of Pediatrics]
Vanbesien, J [Brussels University Hospital, Belgium > Department of Pediatrics]
De Waele, K []
Van Aken, S [Ghent University Hospital and Ghent University, Belgium > Department of Pediatrics,]
Craen, M [Ghent University Hospital and Ghent University, Belgium > Department of Pediatrics]
Vögele, Claus mailto [University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE) >]
Cools [Ghent University Hospital and Ghent University, Belgium > Department of Pediatrics]
Haraldsen, IR [Oslo University Hospital, Norway > Department of Psychosomatic Medicine]
2016
Frontiers in Psychology
Switzerland Frontiers Research Foundation
7
1053
Yes (verified by ORBilu)
International
1664-1078
Pully
Switzerland
[en] Gonadotropin releasing hormone ; Gonadotropin releasing hormone analog ; Cognitive Function ; Emotion Regulation ; Psychosocial problems ; Behavioral problems ; heart rate variability (HRV) ; central precocious puberty ; Puberty
[en] Central precocious puberty (CPP) develops due to premature activation of the hypothalamic-pituitary-gonadal (HPG) axis, resulting in early pubertal changes and rapid bone maturation. CPP is associated with lower adult height and increased risk for development of psychological problems. Standard treatment of CPP is based on postponement of pubertal development by blockade of the HPG axis with gonadotropin releasing hormone analogs (GnRHa) leading to abolition of gonadal sex hormones synthesis. Whereas the hormonal and auxological effects of GnRHa are well researched, there is a lack of knowledge whether GnRHa treatment influences psychological functioning of treated children, despite the fact that prevention of psychological problems is used as one of the main reasons for treatment initiation. In the present study we seek to address this issue by exploring differences in cognitive function, behavior, emotional reactivity, and psychosocial problems between GnRHa treated CPP girls and age-matched controls.
Fifteen girls with idiopathic CPP; median age 10.4 years, treated with slow-release GnRHa (triptorelin acetate – Decapeptyl SR ® 11.25) and 15 age-matched controls, were assessed with a comprehensive test battery consisting of paper and pencil tests, computerized tasks, behavioral paradigms, heart rate variability, and questionnaires filled in by the children’s parents. Both groups showed very similar scores with regard to cognitive performance, behavioral and psychosocial problems. Compared to controls, treated girls displayed significantly higher emotional reactivity (p = 0.016; Cohen’s d = 1.04) on one of the two emotional reactivity task conditions. Unexpectedly, the CPP group showed significantly lower resting heart rates than the controls (p = 0.004; Cohen’s d = 1.03); lower heart rate was associated with longer treatment duration (r = - 0.582, p = 0.037).
The results suggest that GnRHa treated CPP girls do not differ in their cognitive or psychosocial functioning from age matched controls. However, they might process emotional stimuli differently. The unexpected finding of lower heart rate that was associated with longer duration of the treatment should be further explored by methods appropriate for assessment of cardiac health.
http://hdl.handle.net/10993/27956
10.3389/fpsyg.2016.01053

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