Reference : Analysis of the dynamic co-expression network of heart regeneration in the zebrafish
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
Systems Biomedicine
http://hdl.handle.net/10993/27815
Analysis of the dynamic co-expression network of heart regeneration in the zebrafish
English
Rodius, Sophie mailto [Luxembourg Institute of Health (LIH) > Oncology Department > NorLux Neuro-Oncology Laboratory]
Androsova, Ganna mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > > ; Luxembourg Institute of Health (LIH) > Oncology Department > NorLux Neuro-Oncology Laboratory]
Götz, Lou mailto [SIB Swiss Institute of Bioinformatics > Vital-IT Systems Biology Division]
Liechti, Robin mailto [SIB Swiss Institute of Bioinformatics > Vital-IT Systems Biology Division]
Crespo, Isaac mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > > ; SIB Swiss Institute of Bioinformatics > Vital-IT Systems Biology Division]
Merz, Susanne mailto [Luxembourg Institute of Health (LIH) > Oncology Department > NorLux Neuro-Oncology Laboratory]
Nazarov, Petr mailto [Luxembourg Institute of Health (LIH) > Oncology Department > Genomics Research Unit]
de Klein, Niek mailto [Luxembourg Institute of Health (LIH) > Oncology Department > NorLux Neuro-Oncology Laboratory > ; Vrije Universiteit Amsterdam - VU > > > ; University of Groningen > Department of Genetics]
Jeanty, Céline mailto [Luxembourg Institute of Health (LIH) > Oncology Department > NorLux Neuro-Oncology Laboratory]
González-Rosa, Juan mailto [Cardiovascular Research Center]
Muller, Arnaud mailto [Luxembourg Institute of Health (LIH) > Oncology Department > Genomics Research Unit]
Bernardin, Francois mailto [Luxembourg Institute of Health (LIH) > Oncology Department > Genomics Research Unit]
Niclou, Simone mailto [Luxembourg Institute of Health (LIH) > Oncology Department > NorLux Neuro-Oncology Laboratory]
Vallar, Laurent mailto [Luxembourg Institute of Health (LIH) > Oncology Department > Genomics Research Unit]
Mercader, Nadia mailto [Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) > Epicardium Development and Regeneration group > > ; University of Bern > Faculty of Medicine > Institute of Anatomy > Department of Development and Regeneration]
Ibberson, Mark mailto [SIB Swiss Institute of Bioinformatics > Vital-IT Systems Biology Division]
Xenarios, Ioannis mailto [SIB Swiss Institute of Bioinformatics > Vital-IT Systems Biology Division > > ; University of Lausanne > Center for Integrative Genomics > > ; University of Geneva > Department of Biochemistry]
Azuaje, Francisco mailto [Luxembourg Institute of Health (LIH) > Oncology Department > NorLux Neuro-Oncology Laboratory]
31-May-2016
Scientific Reports
Nature Publishing Group
6
Yes (verified by ORBilu)
International
2045-2322
London
United Kingdom
[en] Network topology ; Regulatory networks ; Transcriptomics
[en] The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart regeneration. To enable systematic insights into this phenomenon, we generated and integrated a dynamic co-expression network of heart regeneration in the zebrafish and linked systems-level properties to the underlying molecular events. Across multiple post-injury time points, the network displays topological attributes of biological relevance. We show that regeneration steps are mediated by modules of transcriptionally coordinated genes, and by genes acting as network hubs. We also established direct associations between hubs and validated drivers of heart regeneration with murine and human orthologs. The resulting models and interactive analysis tools are available at http://infused.vital-it.ch. Using a worked example, we demonstrate the usefulness of this unique open resource for hypothesis generation and in silico screening for genes involved in heart regeneration.
Luxembourg’s National Research Fund (FNR), Swiss National Research Foundation (SNF)
Researchers ; Professionals ; Students
http://hdl.handle.net/10993/27815
10.1038/srep26822
http://www.nature.com/articles/srep26822#abstract

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