Reference : The emergence of plasma membrane calcium pump as a novel therapeutic target for heart...
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/10993/27521
The emergence of plasma membrane calcium pump as a novel therapeutic target for heart disease.
English
Oceandy, Delvac [> >]
Buch, Mamta H. [> >]
Cartwright, Elizabeth J. [> >]
Neyses, Ludwig mailto [University of Luxembourg > Research Office]
2006
Mini reviews in medicinal chemistry
6
5
583-8
Yes (verified by ORBilu)
International
1389-5575
Netherlands
[en] Calcium-Transporting ATPases/antagonists & inhibitors/chemistry/drug effects ; Cation Transport Proteins/antagonists & inhibitors/chemistry/drug effects ; Cell Division ; Enzyme Inhibitors/pharmacology ; Heart Diseases/drug therapy/metabolism ; Humans ; Plasma Membrane Calcium-Transporting ATPases ; Signal Transduction ; Subcellular Fractions/enzymology
[en] The plasma membrane calcium/calmodulin dependent ATPase (PMCA) is a calcium-extruding enzymatic pump important in the control of intracellular calcium concentration. PMCA is the only system for calcium extrusion in the majority of cells. In excitable cells such as cardiomyocytes however, PMCA has been shown to play only a minor role in calcium homeostasis. In these cells the main mechanism of calcium extrusion is the sodium calcium exchanger. However, increasing evidence points to an important role for PMCA in signal transduction; in particular in the nitric oxide signalling pathway. In this review we will discuss recent advances that support a key role for PMCA in signal transduction and the potential for therapeutic targeting of this molecule in the treatment of cardiac diseases.
http://hdl.handle.net/10993/27521
10.2174/138955706776876177
http://www.eurekaselect.com/57053/article

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