Reference : Serum metabolomics reveals many novel metabolic markers of heart failure, including p...
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/10993/27461
Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate
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Dunn, W. B. And Broadhurst [The Manchester Centre for Integrative Systems Biology, Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess St., Manchester M1 7DN, United Kingdom]
Deepak, S. M. [School of Chemistry, Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess St., Manchester M1 7DN, United Kingdom]
Buch, M. H. [Division of Cardiovascular and Endocrine Sciences, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PL, United Kingdom]
McDowell, G. [Department of Cardiology, South Manchester University Hospital, Southmoor Road, Wythenshawe, Manchester M23 9LT, United Kingdom]
Spasic, I. [Department of Clinical Biochemistry, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom]
Ellis, D. I. [> >]
Brooks, N. [> >]
Kell, D. B. [> >]
Neyses, Ludwig mailto [University of Luxembourg > Rectorate > Research Service]
2007
Metabolomics
3
4
413-426
Yes
15733882
2-oxoglutarate; Biomarkers; Heart failure; Metabolomics; Pseudouridine
There is intense interest in the identification of novel biomarkers which improve the diagnosis of heart failure. Serum samples from 52 patients with systolic heart failure (EF< 40% plus signs and symptoms of failure) and 57 controls were analyzed by gas chromatography - time of flight - mass spectrometry and the raw data reduced to 272 statistically robust metabolite peaks. 38 peaks showed a significant difference between case and control (p <5 × 10-5). Two such metabolites were pseudouridine, a modified nucleotide present in t- and rRNA and a marker of cell turnover, as well as the tricarboxylic acid cycle intermediate 2-oxoglutarate. Furthermore, 3 further new compounds were also excellent discriminators between patients and controls: 2-hydroxy, 2-methylpropanoic acid, erythritol and 2,4,6-trihydroxypyrimidine. Although renal disease may be associated with heart failure, and metabolites associated with renal disease and other markers were also elevated (e.g. urea, creatinine and uric acid), there was no correlation within the patient group between these metabolites and our heart failure biomarkers, indicating that these were indeed biomarkers of heart failure and not renal disease per se. These findings demonstrate the power of data-driven metabolomics approaches to identify such markers of disease. © Springer Science+Business Media, LLC 2007.
http://hdl.handle.net/10993/27461
10.1007/s11306-007-0063-5
http://www.scopus.com/inward/record.url?eid=2-s2.0-34447569010&partnerID=40&md5=0982a6a55464d16dc39f7fb7735692a5
cited By 74
Scopus

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