Reference : The stimulation of dendrite growth by Sema3A requires integrin engagement and focal a...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/2740
The stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase.
English
Schlomann, Uwe [> >]
Schwamborn, Jens Christian mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Muller, Myriam [> >]
Fassler, Reinhard [> >]
Puschel, Andreas W. [> >]
2009
Journal of Cell Science
122
Pt 12
2034-42
Yes (verified by ORBilu)
International
0021-9533
1477-9137
England
[en] Animals ; Cells, Cultured ; Cyclic GMP/metabolism ; Dendrites/genetics/physiology ; Embryo, Mammalian ; Enzyme Activation ; Focal Adhesion Protein-Tyrosine Kinases/metabolism/physiology ; Humans ; Integrins/metabolism/physiology ; Mice ; Mice, Knockout ; Protein Binding ; Semaphorin-3A/genetics/metabolism/physiology
[en] The rate and direction of axon and dendrite growth depend on multiple guidance signals and growth factors. Semaphorin 3A (Sema3A) acts as a repellent for axons and attractant for dendrites. Here, we show that the requirement for integrin engagement distinguishes the response of axons and dendrites to Sema3A in hippocampal neurons. Sema3A promotes the extension of hippocampal dendrites by a pathway that requires focal adhesion kinase (FAK). The stimulation of dendrite growth and FAK phosphorylation by Sema3A depend on integrin engagement. Unlike their function as a target of Sema3A during the collapse of axonal growth cones, integrins facilitate the stimulation of dendrite extension. Conditional inactivation of the genes encoding beta1 integrin or FAK blocks the growth-promoting effect of Sema3A but not the collapse of axonal growth cones. Our results demonstrate that different pathways mediate the stimulation of dendrite growth and the collapse of axonal growth cones by Sema3A.
http://hdl.handle.net/10993/2740

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