Reference : Neural stem cells maintain their stemness through protein kinase C zeta-mediated inhi...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/2735
Neural stem cells maintain their stemness through protein kinase C zeta-mediated inhibition of TRIM32.
English
Hillje, Anna-Lena [> >]
Worlitzer, Maik M. A. [> >]
Palm, Thomas [> >]
Schwamborn, Jens Christian mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
2011
Stem Cells
Wiley
29
9
1437-47
Yes (verified by ORBilu)
International
1066-5099
1549-4918
Malden
MA
[en] Animals ; Cell Differentiation/physiology ; Cell Growth Processes/physiology ; Down-Regulation ; Immunohistochemistry ; Mice ; Neural Stem Cells/cytology/enzymology ; Protein Kinase C/metabolism ; Stem Cells/cytology/enzymology ; Transfection ; Ubiquitin-Protein Ligases/antagonists & inhibitors/genetics/metabolism
[en] Several studies over the last couple of years have delivered insights into the mechanisms that drive neuronal differentiation. However, the mechanisms that ensure the maintenance of stemness characteristics in neural stem cells over several rounds of cell divisions are still largely unknown. Here, we provide evidence that the neuronal fate determinant TRIM32 binds to the protein kinase C zeta. Through this interaction, TRIM32 is retained in the cytoplasm. However, during differentiation, this interaction is abrogated and TRIM32 translocates to the nucleus to initiate neuronal differentiation by targeting c-Myc for proteasomal degradation.
http://hdl.handle.net/10993/2735
10.1002/stem.687
Copyright (c) 2011 AlphaMed Press.

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